Receptors for peptides from insects

ABSTRACT

The invention relates to polypeptides having the biological activity of peptide receptors, and to nucleic acids encoding these polypeptides, and in particular to their use for finding active compounds for crop protection.

[0001] The invention relates to polypeptides having the biological activity of peptide receptors, and to nucleic acids encoding these polypeptides, and in particular to their use for finding active compounds for crop protection.

[0002] Neuronal or endocrine peptides from insects are important target proteins for the development of novel insecticides, since such peptides regulate most of the important key functions, such as, for example, embryonal and postembryonal development, homeostasis, osmoregulation or muscle activity, in insects (see Gäde et al., 1997a; Osborne, 1996). The biological action of these peptides is mediated by binding to specific receptor proteins in insect cells. Many of these endocrines or neuronal peptides interact with G-protein-coupled receptors (GPCRs; King and Wilson, 1999) which, after binding of a corresponding peptide ligand, activate heterotrimeric G-proteins (Vanden Broeck et al., 1997). Agonists or antagonists of peptide receptors may, for example, interfere with normal insect development, with growth, behaviour or homeostasis, thus representing novel insect-specific and receptor-specific insecticides. These agonists or antagonists of peptide receptors can either be derived from the natural peptides or have an entirely novel chemical structure.

[0003] Since the isolation of the neuropeptide proctolin from preparations of insect muscles (Brown and Starratt, 1975), a large number of peptides from various insect species have been isolated and characterized (see Vanden Broeck et al., 1997; Osborne, 1996), for reviews). Substantial progress has been made in particular in the elucidation of the amino acid sequence of such peptides and in the elucidation of the biological function in the corresponding insect species. Thus, for example, peptides which can regulate the biosynthesis of juvenile hormones (allatotropines and allatostatines; Tobe et al., 1994), insulin-like peptides (Lagueux et al., 1990), peptides which regulate water homeostasis (Coast, 1998) or peptides which can control muscle activity (Holman, 1986; for a review, see Gäde , 1997b) have been isolated from various species. The biological functions of the peptides can be examined in various tests in which, for example, muscle activity (Holman et al., 1991) or the excretion of water and electrolytes (Ramsey, 1954) is measured.

[0004] Whereas a large number of peptides have been isolated, their structure elucidated and the amino acid sequence described, in insects only few receptors are known which are capable of binding endocrine or neuronal peptides (Reagan, 1994; Osborne, 1996; Birgul et al., 1999). It is therefore of great practical importance to provide peptide-binding receptors from insects, for example in the search for novel insecticides.

[0005] The present invention is therefore based, in particular, on the object of providing receptors from insects, hereinbelow referred to as receptors, which are capable of binding to endocrine or neuronal peptides from insects and which, by binding to the peptides, are capable of mediating the biological functions of these peptides, and of providing assay systems based thereon with a high throughput of test compounds (High Throughput Screening Assays; HTS Assays).

[0006] This object is achieved by providing polypeptides having at least one biological activity of a peptide receptor and comprising an amino acid sequence having at least 70% identity, preferably at least 80% identity, particularly preferably at least 90% identity, very particularly preferably at least 95% identity, with a sequence of SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44 or 46 over a length of at least 20, preferably at least 25, particularly preferably at least 30 consecutive amino acids, and very particularly preferably over their full length.

[0007] The degree of identity of the amino acid sequences is preferably determined using the program GAP from the program package GCG, Version 9.1, with standard settings (Devereux et al., 1984).

[0008] The term “polypeptides” as used in the present context not only relates to short amino acid chains which are usually referred to as peptide oligopeptides or oligomers, but also to longer amino acid chains which are usually referred to as proteins. It encompasses amino acid chains which can be modified either by natural processes, such as post-translational processing, or by chemical prior-art methods. Such modifications may occur at various sites and repeatedly in a polypeptide, such as, for example, on the peptide backbone, on the amino acid side chain, on the amino and/or the carboxyl terminus. For example, they encompass acetylations, acylations, ADP-ribosylations, amidations, covalent linkages to flavins, haem-moieties, nucleotides or nucleotide derivatives, lipids or lipid derivatives or phosphatidylinositol, cyclizations, disulphide bridge formations, demethylations, cystine formations, formylations, gamma-carboxylations, glycosylations, hydroxylations, iodinations, methylations, myristoylations, oxidations, proteolytic processings, phosphorylations, selenoylations and tRNA-mediated amino acid additions.

[0009] The polypeptides according to the invention may exist in the form of “mature” proteins or parts of larger proteins, for example as fusion proteins. They can furthermore exhibit secretion or leader sequences, pro-sequences, sequences which allow simple purification, such as multiple histidine residues, or additional stabilizing amino acids.

[0010] The polypeptides according to the invention need not constitute complete receptors, but may also be fragments thereof, as long as they still have at least one biological activity of the complete receptors. Polypeptides which, compared to receptors consisting of the polypeptides according to the invention having an amino acid sequence of SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44 or 46, have an activity which is increased or reduced by 50%, are still considered to be in accordance with the invention. The polypeptides according to the invention need not be deducible from Drosophila melanogaster receptors. Polypeptides which are also considered as being in accordance with the invention are those which correspond to receptors of, for example, the following invertebrates, or fragments thereof which can still exert the biological activity of these receptors: insects, nematodes, arthropods, molluscs.

[0011] In comparison to the corresponding region of naturally occurring receptors, the polypeptides according to the invention can have deletions or amino acid substitutions, as long as they still exert at least one biological activity of the complete receptors. Conservative substitutions are preferred. Such conservative substitutions comprise variations in which one amino acid is replaced by another amino acid from the following group:

[0012] 1. small aliphatic residues, non-polar or of little polarity: Ala, Ser, Thr, Pro and Gly;

[0013] 2. polar negatively charged residues and their amides: Asp, Asn, Glu and Gln;

[0014] 3. polar positively charged residues: His, Arg and Lys;

[0015] 4. large aliphatic non-polar residues: Met, Leu, Ile, Val and Cys; and

[0016] 5. aromatic residues: Phe, Tyr and Trp.

[0017] Preferred conservative substitutions are shown in the list below: Original residue Substitution Ala Gly, Ser Arg Lys Asn Gln, His Asp Glu Cys Ser Gln Asn Glu Asp Gly Ala, Pro His Asn, Gln Ile Leu, Val Leu Ile, Val Lys Mg, Gln, Glu Met Leu, Tyr, Ile Phe Met, Leu, Tyr

[0018] Original residue Substitution Ser Thr Thr Ser Trp Tyr Tyr Trp, Phe Val Ile, Leu

[0019] The term “biological activity of a peptide receptor” as used in the present context means binding of a peptide to the receptor.

[0020] Preferred embodiments of the polypeptides according to the invention are Drosophila melanogaster receptors which have the amino acid sequence of SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44 or 46.

[0021] The present invention also provides nucleic acids which encode the polypeptides according to the invention.

[0022] The nucleic acids according to the invention are, in particular, single-stranded or double-stranded deoxyribonucleic acids (DNA) or ribonucleic acids (RNA). Preferred embodiments are fragments of genomic DNA which may contain introns, and cDNAs.

[0023] Preferred embodiments of the nucleic acids according to the invention are cDNAs having a nucleic acid sequence of SEQ ID NO:1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43 or 45.

[0024] Nucleic acids which hybridize under stringent conditions with sequences of SEQ ID NO:1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43 or 45 are likewise included in the present invention.

[0025] The term “to hybridize” as used in the present context describes the process during which a single-stranded nucleic acid molecule undergoes base pairing with a complementary strand. Starting from the sequence information disclosed herein, this allows, for example, DNA fragments to be isolated from insects other than Drosophila melanogaster which encode polypeptides with the biological activity of receptors.

[0026] Preferred hybridization conditions are given below:

[0027] Hybridization solution: 6×SSC /0% formamide, preferred hybridization solution: 6×SSC/25% formamide.

[0028] Hybridization temperature: 34° C., preferred hybridization temperature: 42° C.

[0029] Wash step 1: 2×SSC at 40° C.,

[0030] Wash step 2: 2×SSC at 45° C.; preferred wash step 2: 0.6×SSC at 55° C.; particularly preferred wash step 2: 0.3×SSC at 65° C.

[0031] The present invention furthermore encompasses nucleic acids which have at least 70% identity, preferably at least 80% identity, particularly preferably at least 90% identity, very particularly preferably at least 95% identity, with a sequence of SEQ ID NO:1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43 or 45 over a length of at least 20, preferably at least 25, particularly preferably at least 30, consecutive nucleotides, and very particularly preferably over their full length.

[0032] The degree of identity of the nucleic acid sequences is preferably determined with the aid of the program GAP from the program package GCG, Version 9.1, using standard settings.

[0033] The present invention furthermore provides DNA constructs which comprise a nucleic acid according to the invention and a heterologous promoter.

[0034] The term “heterologous promoter” as used in the present context refers to a promoter which has properties which differ from the properties of the promoter which controls the expression of the gene in question in the original organism. The term “promoter” as used in the present context generally refers to expression control sequences. The choice of heterologous promoters depends on whether pro- or eukaryotic cells or cell-free systems are used for expression. Examples of heterologous promoters are the early or late promoter of SV40, of the adenovirus or of the cytomegalovirus, the lac system, the trp system, the main operator and promoter regions of the lambda phage, the fd coat protein control regions, the 3-phosphoglycerate kinase promoter, the acid phosphatase promoter and the yeast α-mating factor promoter.

[0035] The invention furthermore provides vectors which contain a nucleic acid according to the invention or a DNA construct according to the invention. All plasmids, phasmids, cosmids, YACs or synthetic chromosomes used in molecular biology laboratories can be used as vectors.

[0036] The present invention also provides host cells which contain a nucleic acid according to the invention, a DNA construct according to the invention or a vector according to the invention.

[0037] The term “host cell” as used in the present context refers to cells which do not naturally comprise the nucleic acids according to the invention.

[0038] Suitable host cells are both prokaryotic cells, such as bacteria from the genera Bacillus, Pseudomonas, Streptomyces, Streptococcus, Staphylococcus, preferably E. coli, and eukaryotic cells, such as yeasts, mammalian cells, amphibian cells, insect cells or plant cells. Preferred eukaryotic host cells are HEK-293, Schneider S2, Spodoptera Sf9, Kc, CHO, COS1, COS7, HeLa, C127, 3T3 or BHK cells and, in particular, Xenopus oocytes.

[0039] The invention furthermore provides antibodies which bind specifically to the above-mentioned polypeptides or receptors. Such antibodies are produced in the customary manner. For example, such antibodies may be produced by injecting a substantially immunocompetent host with such an amount of a polypeptide according to the invention or a fragment thereof which is effective for antibody production, and subsequently obtaining this antibody. Furthennore, an immortalized cell line which produces monoclonal antibodies may be obtained in a manner known per se. If appropriate, the antibodies may be labelled with a detection reagent. Preferred examples of such a detection reagent are enzymes, radiolabelled elements, fluorescent chemicals or biotin. Instead of the complete antibody, it is also possible to employ fragments which have the desired specific binding properties. The term “antibodies” as used in the present context therefore also extends to parts of complete antibodies, such as Fa, F(ab′)₂ or Fv fragments, which are still capable of binding to the epitopes of the polypeptides according to the invention.

[0040] The nucleic acids according to the invention can be used, in particular, for generating transgenic invertebrates. These may be employed in assay systems which are based on an expression, of the polypeptides according to the invention, which deviates from the wild type. Based on the information disclosed herein, it is furthermore possible to generate transgenic invertebrates where expression of the polypeptides according to the invention is altered owing to the modification of other genes or promoters.

[0041] The transgenic invertebrates are generated, for example, in the case of Drosophila melanogaster, by P-element-mediated gene transfer (Hay et al., 1997) or, in Caenorhabditis elegans, by transposon-mediated gene transfer (for example by Tcl; Plasterk, 1996).

[0042] The invention therefore also provides transgenic invertebrates which contain at least one of the nucleic acids according to the invention, preferably transgenic invertebrates of the species Drosophila melanogaster or Caenorhabditis elegans, and their transgenic progeny. The transgenic invertebrates preferably contain the polypeptides according to the invention in a form which deviates from the wild type.

[0043] The present invention furthermore provides methods of producing the polypeptides according to the invention. To produce the polypeptides encoded by the nucleic acids according to the invention, host cells which contain one of the nucleic acids according to the invention can be cultured under suitable conditions, where the nucleic acid to be expressed may be adapted to the codon usage of the host cells. Thereupon, the desired polypeptides can be isolated from the cells or the culture medium in a customary manner. The polypeptides may also be produced in in vitro systems.

[0044] A rapid method of isolating the polypeptides according to the invention which are synthesized by host cells using a nucleic acid according to the invention starts with the expression of a fusion protein, it being possible for the fusion partner to be affinity-purified in a simple manner. For example, the fusion partner may be glutathione S-transferase. The fusion protein can then be purified on a glutathione affinity column. The fusion partner can then be removed by partial proteolytic cleavage, for example at linkers between the fusion partner and the polypeptide according to the invention to be purified. The linker can be designed such that it includes target amino acids, such as arginine and lysine residues, which define sites for trypsin cleavage. To generate such linkers, standard cloning methods using oligonucleotides may be employed.

[0045] Other purification methods which are possible are based on preparative electrophoresis, FPLC, HPLC (for example using gel filtration, reversed-phase or moderately hydrophobic columns), gel filtration, differential precipitation, ion-exchange chromatography and affinity chromatography.

[0046] Since the receptors constitute membrane proteins, the purification methods preferably involve detergent extractions, for example using detergents which have no, or little, effect on the secondary and tertiary structures of the polypeptides, such as nonionic detergents.

[0047] The purification of the polypeptides according to the invention can encompass the isolation of membranes, starting from host cells which express the nucleic acids according to the invention. Such cells preferably express the polypeptides according to the invention in a sufficiently high copy number, so that the polypeptide quantity in a membrane fraction is at least 10 times higher than that in comparable membranes of cells which naturally express the receptors; particularly preferably, the quantity is at least 100 times, very particularly preferably at least 1,000 times, higher.

[0048] The terms “isolation or purification” as used in the present context mean that the polypeptides according to the invention are separated from other proteins or other macromolecules of the cell or of the tissue. The protein content of a composition containing the polypeptides according to the invention is preferably at least 10 times, particularly preferably at least 100 times, higher than in a host cell preparation.

[0049] The polypeptides according to the invention may also be affinity-purified without a fusion partner with the aid of antibodies which bind to the polypeptides.

[0050] The present invention furthermore provides methods for producing the nucleic acids according to the invention. The nucleic acids according to the invention can be produced in a customary manner. For example, all of the nucleic acid molecules can be synthesized chemically, or else only short sections of the sequences according to the invention can be synthesized chemically, and such oligonucleotides can be radiolabelled or labelled with a fluorescent dye. The labelled oligonucleotides can be used for screening cDNA libraries generated starting from insect mRNA or for screening genomic libraries generated starting from insect genomic DNA. Clones which hybridize with the labelled oligonucleotides are chosen for isolating the DNA in question. After characterization of the isolated DNA, the nucleic acids according to the invention are obtained in a simple manner.

[0051] Alternatively, the nucleic acids according to the invention can also be produced by means of PCR methods using chemically synthesized oligonucleotides.

[0052] The term “oligonucleotide(s)” as used in the present context denotes DNA molecules composed of 10 to 50 nucleotides, preferably 15 to 30 nucleotides. They are synthesized chemically and can be used as probes.

[0053] The nucleic acids or polypeptides according to the invention allow novel active compounds for crop protection and/or pharmaceutically active compounds for the treatment of humans and animals to be identified, such as chemical compounds which, being modulators, in particular agonists or antagonists, alter the properties of the receptors according to the invention. To this end, a recombinant DNA molecule comprising at least one nucleic acid according to the invention is introduced into a suitable host cell. The host cell is grown in the presence of a compound or a probe comprising a variety of compounds under conditions which allow expression of the receptors according to the invention. A change in the receptor properties can be detected, for example, as described below in Example 2. This allows, for example, insecticidal substances to be found.

[0054] Receptors alter the concentration of intracellular cAMP via interaction with G-proteins, preferably after previously having been activated. Thus, changes in the receptor properties by chemical compounds can be measured after heterologous expression, for example by measuring the intracellular cAMP concentrations directly via ELISA assay systems (Biomol, Hamburg, Germany) or RIA assay systems (NEN, Schwalbach, Germany) in HTS format. An indirect measurement of the cAMP concentration is possible with the aid of reporter genes (for example luciferase), whose expression depends on the cAMP concentration (Stratowa et al., 1995). The coexpression of receptors with specific G-proteins, for example Gα15, Gα16 or else chimeric G-proteins, in heterologous systems and measuring the increase in calcium, for example using fluorescent dyes or equorin, is an alternative possibility of carrying out the screening (Stables et al., 1997, Conklin et al., 1993).

[0055] Furthermore, the binding of GTP to the activated G-protein can be used as a read-out system for assaying substances. Also, binding experiments with labelled peptides can be employed for screening.

[0056] The term “agonist” as used in the present context refers to a molecule which activates the receptor.

[0057] The term “antagonist” as used in the present context refers to a molecule which displaces an agonist from its binding site.

[0058] The term “modulator” as used in the present context constitutes the generic term for agonist and antagonist. Modulators can be small organochemical molecules, peptides or antibodies which bind to the polypeptides according to the invention. Other modulators may be small organochemical molecules, peptides or antibodies which bind to a molecule which, in turn, binds to the polypeptides according to the invention, thus affecting their biological activity. Modulators may constitute mimetics or natural substrates and ligands.

[0059] The modulators are preferably small organochemical compounds.

[0060] The binding of the modulators to the polypeptides according to the invention can alter the cellular processes in a manner which leads to the death of the insects treated therewith.

[0061] The present invention therefore also extends to the use of modulators of the polypeptides according to the invention as insecticides or pharmaceuticals.

[0062] The nucleic acids or polypeptides according to the invention also allow compounds to be found which bind to the receptors according to the invention. Again, these can be used as insecticides on plants or as pharmaceutically active compounds for the treatment of humans and animals. For example, host cells which contain the nucleic acids according to the invention and which express the corresponding receptors or polypeptides, or the gene products themselves, are brought into contact with a compound or a mixture of compounds under conditions which permit the interaction of at least one compound with the host cells, the receptors or the individual polypeptides.

[0063] Using host cells or transgenic invertebrates which contain the nucleic acids according to the invention, it is also possible to find substances which alter receptor expression.

[0064] The above-described nucleic acids according to the invention, vectors and regulatory regions can furthermore be used for finding genes which encode polypeptides which participate in the synthesis, in insects, of functionally similar receptors. Functionally similar receptors are to be understood as meaning in accordance with the present invention receptors which comprise polypeptides which, while differing from the amino acid sequence of the polypeptides described herein, essentially have the same functions.

Information on the Sequence Listing and the Figures

[0065] SEQ ID NO:1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43 and 45 show the nucleotide and amino acid sequences of the isolated receptor cDNAs. SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44 and 46 furthermore show the amino acid sequences of the proteins deduced from the receptor cDNA sequences.

EXAMPLES Example 1

[0066] Isolation of the above-described polynucleotides

[0067] Polynucleotides were manipulated by standard methods of recombinant DNA technology (Sambrook et al., 1989). Nucleotide and protein sequences were bioinformatically processed using the program package GCG Version 9.1 (GCG Genetics Computer Group, Inc., Madison Wis., USA).

[0068] Isolation of poly-A-containing RNA from Drosophila tissue and construction of the cDNA libraries.

[0069] The RNA for the cDNA library I was isolated from whole Drosophila melanogaster embryos and larvae (RNAzol, Life Technologies, Karlsruhe, Germany, following the instructions of the manufacturer). From this RNA, the poly-A-containing RNAs were then isolated by purification using Dyna Beads 280 (Dynal, Hamburg, Germany). 5 μg of these poly-A-containing RNAs were then employed for constructing the cDNA library using the λ-ZAP-CMV vector (cDNA Synthesis Kit, ZAP-cDNA Synthesis Kit and ZAP-cDNA Gigapack III Gold Cloning Kit, all from Stratagene-Europe, Amsterdam, the Netherlands).

[0070] Generation of plasmid pools

[0071] Following the instructions of the manufacturer, the cDNA library in Lambda-pCMV was subjected to mass in-vivo-excision to generate a phagemide library. 10×96 minipreparation cultures were then sown, each preparation calculated to contain 1,000 clones. The DNA was then purified using the Qiawell Ultra DNA preparation system from Qiagen (Hilden, Germany) and deposited in 96-well microtitre plates. In this way, the library was represented in the form of 960 pools of 1,000 cDNA clones each.

[0072] PCR with library pools.

[0073] Each microtitre plate was copied to a meta pool which represented the entire plate. In each case 0.5 μl of this meta pool was used for a PCR with the following oligodeoxynucleotide primers:

[0074] Primer 1s: AAGGTCATCAAAATGCTGATT (SEQ ID NO:47)

[0075] Primer 1a: ATTGTAGCAGCTATTGCTCAT (SEQ ID NO:48)

[0076] Primer 2s: CAGCTCGTTCGATTCGGTCCT (SEQ ID NO:49)

[0077] Primer 2a: GTGACAGCGGTCATAGTCCGA (SEQ ID NO:50)

[0078] Primer 3s: ATCGAGGCATCCACCTATGGC (SEQ ID NO:51)

[0079] Primer 3a: AGGTGGGCGCAGGCATCGTAG (SEQ ID NO:52)

[0080] Primer 4s: TTGCTACGTAGTTCTGAGGAATC (SEQ ID NO:53)

[0081] Primer 4a: ATGCAGGTGGAGAGCTTCATG (SEQ ID NO:54)

[0082] Primer 5s: TGGCAGACGAGTGCTTCCTGA (SEQ ID NO:55)

[0083] Primer 5a: GGACCGCTGAAGTTGACCAG (SEQ ID NO:56)

[0084] Primer 6s: TGGTCTGGTACCTGCTGGTCA (SEQ ID NO:57)

[0085] Primer 6a: GCGATGAGCCATTTGACCAGC (SEQ ID NO:58)

[0086] Primer 7s: GTGACCCATGCGTTCATCATC (SEQ ID NO:59)

[0087] Primer 7a: CTGCAGCATGGGCAGAAAG (SEQ ID NO:60)

[0088] Primer 8s: GCGATCACCTGGAAGATCTGC (SEQ ID NO:61)

[0089] Primer 8a: TGGTGATGCCAATAGGATACC (SEQ ID NO:62)

[0090] Primer 9s: CTGTTGCACTTCCTGGTCTAC (SEQ ID NO:63)

[0091] Primer 9a: ACGCACAGCTCCCTGAATTTC (SEQ ID NO:64)

[0092] Primer 10s: GAGGAGCACGATGTGAGTGG (SEQ ID NO:65)

[0093] Primer 10a: CGTGTAAACGGATAATTCTG (SEQ ID NO:66)

[0094] Primer 11s: GTCTGGCTGATACCCAGCTA (SEQ ID NO:67)

[0095] Primer 11a: ACGCTCTTGACTTTCTCGAAC (SEQ ID NO:68)

[0096] Primer 12s: TTCGCACACCAGTTCTACGAC (SEQ ID NO:69)

[0097] Primer 12a: GCGTTCATGAAGCAGTAGGTG (SEQ ID NO:70)

[0098] Primer 13s: TACATCTGCATCGGACGTGG (SEQ ID NO:71)

[0099] Primer 13a: CACTATGCCGCATTGCTCC (SEQ ID NO:72)

[0100] Primer 14s: GTGATCTATGTGGTGATGAGG (SEQ ID NO:73)

[0101] Primer 14a: CCTCGACTGCACGGTGCTGGC (SEQ ID NO:74)

[0102] Primer 15s: GTCATCGTTCTGGGCAATTCA (SEQ ID NO:75)

[0103] Primer 15a: GATGCTCATGGCCACCAGCAC (SEQ ID NO:76)

[0104] Primer 16s: AACGTACTGCGAGTGATCGTG (SEQ ID NO:77)

[0105] Primer 16a: AATGGCAAAGGTGACATCGTG (SEQ ID NO:78)

[0106] Primer 17s: ATGTGCCGCATCAGCGAGTTC (SEQ ID NO:79)

[0107] Primer 17a: GTTACCGGTGGCTGTGAACAC (SEQ ID NO:80)

[0108] Primer 18s: CAGAAACCGCTCAAGGAGACG (SEQ ID NO:81)

[0109] Primer 18a: CCTCAGACGAGCCGCAGTTAG (SEQ ID NO:82)

[0110] Primer 19s: GCACTGGCACTGCTGCTGG (SEQ ID NO:83)

[0111] Primer 19a: CACAGCCACCACGGTGATGC (SEQ ID NO:84)

[0112] Primer 20s: GGCACTTTGCCGTGGATAGTG (SEQ ID NO:85)

[0113] Primer 20a: GAACCGATCGATGGACATCAG (SEQ ID NO:86)

[0114] Primer 21s: CATCAGCTCCTACCTGCTGC (SEQ ID NO:87)

[0115] Primer 21a: CGTAGAGCAGCGGATTGATAC (SEQ ID NO:88)

[0116] Primer 22s: CATCTCACTGGCCTGCAGTGA (SEQ ID NO:89)

[0117] Primer 22a: CATGCTCAGAGTCGACTTCG (SEQ ID NO:90)

[0118] Primer 23s: GCGGTAATGGCACTGTTCTC (SEQ ID NO:91)

[0119] Primer 23a: GGATACTGTGGAGAACCGGTA (SEQ ID NO:92)

[0120] The PCR parameters were as follows: 94° C., 1 min; 35 times (94° C., 30 s; 55° C., 30 s; 72° C., 45 s). The PCRs were carried out on a Biometra Uno II (Biometra, Göttingen, Germany).

[0121] Library pools which were positive in the PCR were transformed in X1-1 Blue (Stratagene, Amsterdam, the Netherlands) and subjected to a colony lift (Sambrook et al., 1989). The probe used for the hybridization was a PCR product of the reaction with the respective primer pair (hybridization and detection by means of BrightStar, psoralene-biotin kit, Ambion, Austin, Tex., USA), labelled using psoralene-biotin (BrightStar, psoralene-biotin kit, Ambion, Austin, Tex., USA). Positive colonies were selected and grown, and the DNA was isolated by plasmid preparation (Qiagen, Hilden, Germany).

[0122] For identification, the isolated gene library plasmids were subjected to incipient sequencing (ABI Prism Dye Terminator Cycle Sequencing Kit, ABI, using the ABI prism 310 genetic analyser, ABI-Deutschland, Weiterstadt, Germany) using T3 and T7 primers. The complete polynucleotide sequences of the DB3 were determined by primer walking by means of the Cycle Sequencing ABI Prism Dye Terminator Cycle Sequencing Kit, ABI, using an ABI prism 310 genetic analyser (ABI-Deutschland, Weiterstadt, Germany).

Example 2

[0123] The sequences of SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44 or 46 were assigned by blast analysis (Altschul et al., 1997). What is shown is in each case the best hit from the blast analysis (Swissprot database of 4 March 2000). The E-value parameter is a measure for the non-randomness of the assignment. With sufficient reliability, all sequences were identified as neuropeptide receptors.

Sequence Comparison and Assignment of the Sequences

[0124] Accession No./Accession from Swissprot database Seq ID E value (4 March 2000) 2 8e-45 P25931/NEUROPEPTIDE Y RECEPTOR (NPY-R) (PR4 RECEPTOR) 4 1e-81 Q16983/DIURETIC HORMONE RECEPTOR PRECURSOR (DH-R) 6 1e-76 Q16983/DIURETIC HORMONE RECEPTOR PRECURSOR (DH-R) 8 7e-41 Q9Z2D5/NEUROPEPTIDE Y RECEPTOR TYPE 2 (NPY2-R) 10 8e-52 P35346/SOMATOSTATIN RECEPTOR TYPE 5 (SS5R) 12 Q16602/CALCITONIN GENE-RELATED PEPTIDE TYPE 1 RECEPTOR 14 2e-05 P56718/OREXIN RECEPTOR TYPE 1 (OX1R) 16 6e-25 Q9Z2D5/NEUROPEPTIDE Y RECEPTOR TYPE 2 (NPY2-R) 18 1e-40 P21729/GASTRIN-RELEASING PEPTIDE RECEPTOR (GRP-R) 20 1e-86 O02721/LUTROPIN-CHORIOGONADOTROPIC HORMONE RECEPTOR 22 6e-19 Q63931/CHOLECYSTOKININ TYPE A RECEPTOR (CCK-A RECEPTOR) 24 1e-33 P56418/GASTRIN/CHOLECYSTOKININ TYPE B RECEPTOR 26 4e-34 Q95254/GROWTH HORMONE SECRETAGOGUE RECEPTOR TYPE 1 28 7e-54 P34993/SOMATOSTATIN RECEPTOR TYPE 2 (SS2R) 30 3e-41 P48043/VASOPRESSIN V1A RECEPTOR 32 5e-42 Q60755/CALCITONIN RECEPTOR PRECURSOR (CT-R) 34 7e-39 P47751/PHE(13) BOMBESIN RECEPTOR 36 6e-22 P70031/CHOLECYSTOKININ RECEPTOR (CCK-XLR) 38 6e-41 Q9Z2D5/NEUROPEPTIDE Y RECEPTOR TYPE 2 (NPY2-R) 40 1e-19 O88626/GALANIN RECEPTOR TYPE 3 (GAL3-R) 42 5e-15 P47211/GALANIN RECEPTOR TYPE 1 (GAL1-R) 44 2e-08 Q95254/GROWTH HORMONE SECRETAGOGUE RECEPTOR TYPE 1 46 7e-17 Q62463/VASOPRESSIN V1A RECEPTOR

Example 3 Heterologous Expression

[0125] The receptors from insects can be expressed functionally in xenopus ooctyes. To this end, G-protein-activatable potassium channels (GIRK1 and GIRK4) are coexpressed in order to measure activation of the receptors (White et al., 1998). The nucleotide sequences according to the invention were used directly for the expression experiments, since they were already in an expression vector with CMV promoter.

Oocyte Measurements 1. Oocyte Preparation

[0126] The oocytes are obtained from an adult female Xenopus laevis frog (Horst Kähler, Hamburg, Germany). The frogs are kept in large tanks with circulating water at a water temperature of 20-24° C. Parts of the frog ovary are removed through a small incision in the abdomen (approx. 1 cm), with full anaesthesia. The ovary is then treated for approximately 140 min with 25 ml of collagenase (type I, C-0130, SIGMA-ALDRICH CHEMIE GmbH, Deisenhofen, Germany; 355 U/ml, prepared with Barth's solution without calcium in mM: NaCl 88, KCl 1, MgSO₄ 0.82, Na—HCO₃ 2.4, Tris/HCl 5, pH 7.4), with constant shaking. Then, the oocytes are washed with Barth's solution without calcium. Only oocytes at maturity stage V (Dumont, 1972) are selected for the further treatment and transferred into microtitre plates (Nunc MicroWell™ plates, Cat. No. 245128+263339 (lid), Nunc GmbH & Co. KG, Wiesbaden, Germany), filled with Barth's solution (in mM: NaCl 88, KCl 1, MgSO₄ 0.82, Ca(NO₃)₂ 0.33, CaCl₂ 0.41, NaHCO₃ 2.4, Tris/HCl 5, pH 7.4) and gentamicin (gentamicin sulphate, G-3632, SIGMA-ALDRICH CHEMIE GmbH, Deisenhofen, Germany; 100 U/ml). The oocytes are then kept in a cooling incubator (type KB 53, WTB Binder Labortechnik GmbH, Tuttlingen, Germany) at 19.2° C.

2. Injecting the Oocytes

[0127] Injection electrodes of diameter 10-15 μm are prepared using a pipette-drawing device (type L/M-3P-A, list-electronic, Darmstadt-Eberstadt, Germany). Prior to injection, aliquots with the receptor DNA or GIRK1/4-DNA are defrosted and diluted with water to a final concentration of 10 ng/μl. The DNA samples are centrifuged for 120 s at 3 200 g (type Biofuge 13, Heraeus Instruments GmbH, Hanau, Germany). An extended PE tube is subsequently used as transfer tube to fill the pipettes from the rear end. The injection electrodes are attached to a X,Y,Z positioning system (treatment center EP1090, isel-automation, Eiterfeld, Germany). With the aid of a Macintosh Computer, the oocytes in the microtitre plate wells are approached, and approximately 50 nl of the DNA solution are injected into the oocytes by briefly applying a pressure (0.5-3.0 bar, 3-6 s).

3. Electrophysiological Measurements

[0128] A two-electrode voltage clamp equipped with a TURBO TEC-10CD (npi electronic GmbH, Tamm, Germany) amplifier is used to carry out the electrophysiological measurements. The micropipettes required for this purpose are drawn in two movements from aluminium silicate glass (capillary tube, Art. No. 14 630 29, 1=100 mm, Ø_(ext.)=1.60 mm, Ø_(int.)=1.22 mm, Hilgenberg GmbH, Malsfeld, Germany) (Hamill et al., 1981). Current and voltage electrodes have a diameter of 1-3 μm and are filled with 1.5 M KCl and 1.5 M potassium acetate. The pipettes have a capacitance of 0.2-0.5 MW. To carry out the electrophysiological measurements, the oocytes are transferred into a small chamber which is flushed continuously with normal Rimland solution (in mM: KCl 90, MgCl₂ 3, HEPES 5, pH 7.2). To apply a substance, the perfusion solution is exchanged for a substance solution of the same composition and additionally the desired substance concentration. The successful expression of the receptor DNA is checked after one week at a clamp potential of −60 mV. Unresponsive oocytes are discarded. All the others are used for substance testing. The data are documented by means of a YT plotter (YT plotter, model BD 111, Kipp & Zonen Delft BV, AM Delft, the Netherlands). When test substances are assayed in concentration series, these measurements are carried out on at least two different oocytes and at at least five different concentrations. The substances are assayed directly with-out preincubation in the presence of glutamate (gamma-amino-N-butyric acid, A2129, SIGMA-ALDRICH CHEMIE GmbH, Deisenhofen, Germany) for their antagonists. The individual data are entered in Origin (evaluation software Microcal Origin, Microcal Software, Inc., Northampton, Mass. 01060-4410 USA [lacuna] (Additive GmbH, Friedrichsdorf/Ts, Germany). Means, standard deviation, IC₅₀ values and IC₅₀ curves are calculated using Origin. These measurements are carried out at least in duplicate.

References

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[0130] Birgul, N. et al. (1999), Reverse physiology in Drosophila: identification of a novel allatostatin-like neuropeptide and its cognate receptor structurally related to the mammalian somatostatin/galanin/opioid receptor family, EMBO Journal 18, 5892-5900.

[0131] Brown, B. E. und Starrall, A. N. (1975), Isolation of proctolin, a myotropic peptide from Periplaneta americana, Journal of Insect Physiology 21, 1879-1881.

[0132] Coast, G. M. (1998), Insect Diuretic Peptides: Structures, Evolution and Actions, American Zoology 38, 442-449.

[0133] Conklin et al. (1993), Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha, Nature 20;363(6426):274-6.

[0134] Devereux et al. (1984), Nucleic Acids Research 12, 387.

[0135] Dumont, J. N. (1972), Oogenesis in Xenopus laevis (Daudin). 1. Stages of oocyte development in laboratory maintained animals, J. Morphol. 136: 153-180.

[0136] Gäde , G. (1997a), The explosion of structural information on insect neuropeptides, In: Progress in the chemistry of organic natural products (Herz, W., Kirby, G. W., Moore, R. E., Steglich, W., Tamm, C. eds), 1-128.

[0137] Gäde , G. et al. (1997b), Hormonal regulation in Insects: Facts, Gaps, and Future Directions, Physiological Reviews 77, 963-1032.

[0138] Hamill, O. P., Marty, A., Neher, E., Sakmann, B. Sigworth, F. J. (1981), Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches, Pfügers Arch. 391: 85-100.

[0139] Hay et al. (1997), P element insertion-dependent gene activation in the Drosophila eye, Proceedings of The National Academy of Sciences of The United States of America 94 (10), 5195-5200.

[0140] Holman, G. M. et al. (1986), Isolation, primary structure and synthesis of two neuropeptides from Leucophaea maderae: Members of a new family of Cephalomaotrophins, Comparative Biochemical Physiology 84C, 205.

[0141] Holman, G. M. (1991), Insect myotropic peptides: isolation, structural characterization and biological properties, In: Insect Neuropeptides: Chemistry, Biology and Action (Menn, J. J., Kelly, T. J., Masler, E. P., eds), 40-50.

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[0143] Lagueux, M. et al. (1990), cDNAs from neurosecretory cells of brains of Locusta migratoria encoding a novel member of the superfamily of insulins, European Journal of Biochemistry 187, 249-254.

[0144] Osborne, R. H. (1996), Insect Neurotransmission: Neurotransmitters and their Receptors, Pharmacology & Therapeutics 69, 117-142.

[0145] Plasterk (1996), The Tcl/mariner transposon family, Transposable Elements/Current Topics in Microbiology and Immunology 204, 125-143

[0146] Ramsey, J. A. (1954), Active transport of water by the Malpighian tubules of the stick insect, Dixippus morosus, Journal of Experimental Biology 31, 104-113.

[0147] Reagan, J. D. (1994), Expression cloning of an insect diuretic hormone receptor, Journal of Biological Chemistry 269, 9-12.

[0148] Sambrook et al. (1989), Molecular Cloning, A Laboratory Manual, 2nd ed. Cold Spring Harbor Press.

[0149] Stables et al. (1997), A Bioluminescent Assay for Agonist Activity at Potentially Any G-protein coupled Receptor, Analytical Biochemistry 252, 115-126.

[0150] Stratowa C et al. (1995), Use of a luciferase reporter system for characterizing G-protein-linked receptors, Current Opinion in Biotechnology 6, 574-581.

[0151] Tobe, S. S. et al. (1994), Allatostatins, peptide inhibitors of juvenile hormone production in insects, In: Perspectives in Comparative Endocrinology (Davey, K. G., Peter, R. E., Tobe, S. S., eds), 12-19.

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0 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 92 <210> SEQ ID NO 1 <211> LENGTH: 1623 <212> TYPE: DNA <213> ORGANISM: Drosophila melanogaster <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(1620) <400> SEQUENCE: 1 atg gac tta atc gag cag gag tcc cgc ctg gaa ttc ctg ccc gga gcc 48 Met Asp Leu Ile Glu Gln Glu Ser Arg Leu Glu Phe Leu Pro Gly Ala 1 5 10 15 gag gag gaa gca gaa ttt gag cgt cta tac gcg gct ccc gct gag att 96 Glu Glu Glu Ala Glu Phe Glu Arg Leu Tyr Ala Ala Pro Ala Glu Ile 20 25 30 gtg gcc ctg ttg tcc att ttc tat ggg gga atc agt atc gtg gcc gtc 144 Val Ala Leu Leu Ser Ile Phe Tyr Gly Gly Ile Ser Ile Val Ala Val 35 40 45 att ggc aac act ttg gtc atc tgg gtg gtg gcc acg acc agg caa atg 192 Ile Gly Asn Thr Leu Val Ile Trp Val Val Ala Thr Thr Arg Gln Met 50 55 60 cgg acc gtg aca aat atg tat atc gct aat ttg gct ttt gcc gat gtg 240 Arg Thr Val Thr Asn Met Tyr Ile Ala Asn Leu Ala Phe Ala Asp Val 65 70 75 80 att att ggc ctc ttc tgc ata cca ttt cag ttc cag gct gcc ctg ctg 288 Ile Ile Gly Leu Phe Cys Ile Pro Phe Gln Phe Gln Ala Ala Leu Leu 85 90 95 cag agt tgg aac ctg ccg tgg ttc atg tgc agc ttc tgc ccc ttc gtc 336 Gln Ser Trp Asn Leu Pro Trp Phe Met Cys Ser Phe Cys Pro Phe Val 100 105 110 cag gcc ctg agt gta aat gtc tcg gta ttc acg ctg acc gcc att gca 384 Gln Ala Leu Ser Val Asn Val Ser Val Phe Thr Leu Thr Ala Ile Ala 115 120 125 atc gat cgg cat agg gcc atc att aat cca ctt agg gca cgt ccc acc 432 Ile Asp Arg His Arg Ala Ile Ile Asn Pro Leu Arg Ala Arg Pro Thr 130 135 140 aag ttc gta tcg aag ttc ata att ggt gga att tgg atg ctg gcc ctg 480 Lys Phe Val Ser Lys Phe Ile Ile Gly Gly Ile Trp Met Leu Ala Leu 145 150 155 160 cta ttt gcg gtg ccc ttt gcc att gcc ttt cgt gtg gag gag ttg acc 528 Leu Phe Ala Val Pro Phe Ala Ile Ala Phe Arg Val Glu Glu Leu Thr 165 170 175 gaa aga ttt cgc gag aac aat gag acc tac aat gtg acg cgg cca ttc 576 Glu Arg Phe Arg Glu Asn Asn Glu Thr Tyr Asn Val Thr Arg Pro Phe 180 185 190 tgc atg aac aag aac cta tcc gat gat caa ttg caa tcc ttt cgc tac 624 Cys Met Asn Lys Asn Leu Ser Asp Asp Gln Leu Gln Ser Phe Arg Tyr 195 200 205 acc ctg gtt ttt gtg cag tat ctg gtt cca ttc tgt gtc atc agc ttt 672 Thr Leu Val Phe Val Gln Tyr Leu Val Pro Phe Cys Val Ile Ser Phe 210 215 220 gtc tac atc cag atg gcg gta cga ttg tgg ggc aca cgt gct cct ggt 720 Val Tyr Ile Gln Met Ala Val Arg Leu Trp Gly Thr Arg Ala Pro Gly 225 230 235 240 aac gca cag gat tca cgg gac ata acg ctg ttg aaa aac aag aag aag 768 Asn Ala Gln Asp Ser Arg Asp Ile Thr Leu Leu Lys Asn Lys Lys Lys 245 250 255 gtc atc aaa atg ctg att atc gtg gtc att atc ttt gga ctc tgc tgg 816 Val Ile Lys Met Leu Ile Ile Val Val Ile Ile Phe Gly Leu Cys Trp 260 265 270 ctg cca ctg cag ctc tat aat att ctg tat gtc acg ata ccg gaa atc 864 Leu Pro Leu Gln Leu Tyr Asn Ile Leu Tyr Val Thr Ile Pro Glu Ile 275 280 285 aac gac tac cac ttc att agc atc gtc tgg ttt tgc tgc gat tgg ctg 912 Asn Asp Tyr His Phe Ile Ser Ile Val Trp Phe Cys Cys Asp Trp Leu 290 295 300 gcc atg agc aat agc tgc tac aat ccc ttt att tat ggc atc tac aat 960 Ala Met Ser Asn Ser Cys Tyr Asn Pro Phe Ile Tyr Gly Ile Tyr Asn 305 310 315 320 gaa aaa ttt aag cgg gaa ttc aac aag cga ttt gcg gcc tgt ttc tgc 1008 Glu Lys Phe Lys Arg Glu Phe Asn Lys Arg Phe Ala Ala Cys Phe Cys 325 330 335 aag ttc aag acg agc atg gac gcc cac gaa agg acc ttt tcg atg cac 1056 Lys Phe Lys Thr Ser Met Asp Ala His Glu Arg Thr Phe Ser Met His 340 345 350 acc cgc gcc agc tcc ata agg tca acc tac gcc aac tcc tcg atg cga 1104 Thr Arg Ala Ser Ser Ile Arg Ser Thr Tyr Ala Asn Ser Ser Met Arg 355 360 365 atc cgg agt aat ctc ttt ggt ccg gcg cgt ggt ggt gtc aac aat ggg 1152 Ile Arg Ser Asn Leu Phe Gly Pro Ala Arg Gly Gly Val Asn Asn Gly 370 375 380 aag ccg ggc ttg cat atg ccg cgg gtg cat gga tcc ggt gct aac agc 1200 Lys Pro Gly Leu His Met Pro Arg Val His Gly Ser Gly Ala Asn Ser 385 390 395 400 ggc att tac aac gga agt agt ggg cag aac aac aat gtc aat ggc caa 1248 Gly Ile Tyr Asn Gly Ser Ser Gly Gln Asn Asn Asn Val Asn Gly Gln 405 410 415 cat cat cag cat caa agc gtg gtt acc ttt gcg gcc act ccg ggt gtt 1296 His His Gln His Gln Ser Val Val Thr Phe Ala Ala Thr Pro Gly Val 420 425 430 tcg gca cca ggt gtt ggc gtt gca atg ccg ccg tgg cgg cga aac aac 1344 Ser Ala Pro Gly Val Gly Val Ala Met Pro Pro Trp Arg Arg Asn Asn 435 440 445 ttc aaa cct ctg cat ccg aac gta atc gaa tgc gag gac gac gtg gca 1392 Phe Lys Pro Leu His Pro Asn Val Ile Glu Cys Glu Asp Asp Val Ala 450 455 460 ctc atg gag ctg cca tca acc acg ccc ccc agc gag gag ttg gca tcc 1440 Leu Met Glu Leu Pro Ser Thr Thr Pro Pro Ser Glu Glu Leu Ala Ser 465 470 475 480 ggg gcc gga gtc cag ttg gcc ctg cta agc agg gag agc tcc agc tgc 1488 Gly Ala Gly Val Gln Leu Ala Leu Leu Ser Arg Glu Ser Ser Ser Cys 485 490 495 att tgc gaa cag gaa ttt ggc agc caa acc gaa tgc gat ggc acc tgc 1536 Ile Cys Glu Gln Glu Phe Gly Ser Gln Thr Glu Cys Asp Gly Thr Cys 500 505 510 ata ctc agc gag gtg tcg cga gtc cac ctg ccc ggc tcg cag gcg aag 1584 Ile Leu Ser Glu Val Ser Arg Val His Leu Pro Gly Ser Gln Ala Lys 515 520 525 gac aag gat gcg ggc aag tcc ttg tgg caa cca ctt taa 1623 Asp Lys Asp Ala Gly Lys Ser Leu Trp Gln Pro Leu 530 535 540 <210> SEQ ID NO 2 <211> LENGTH: 540 <212> TYPE: PRT <213> ORGANISM: Drosophila melanogaster <400> SEQUENCE: 2 Met Asp Leu Ile Glu Gln Glu Ser Arg Leu Glu Phe Leu Pro Gly Ala 1 5 10 15 Glu Glu Glu Ala Glu Phe Glu Arg Leu Tyr Ala Ala Pro Ala Glu Ile 20 25 30 Val Ala Leu Leu Ser Ile Phe Tyr Gly Gly Ile Ser Ile Val Ala Val 35 40 45 Ile Gly Asn Thr Leu Val Ile Trp Val Val Ala Thr Thr Arg Gln Met 50 55 60 Arg Thr Val Thr Asn Met Tyr Ile Ala Asn Leu Ala Phe Ala Asp Val 65 70 75 80 Ile Ile Gly Leu Phe Cys Ile Pro Phe Gln Phe Gln Ala Ala Leu Leu 85 90 95 Gln Ser Trp Asn Leu Pro Trp Phe Met Cys Ser Phe Cys Pro Phe Val 100 105 110 Gln Ala Leu Ser Val Asn Val Ser Val Phe Thr Leu Thr Ala Ile Ala 115 120 125 Ile Asp Arg His Arg Ala Ile Ile Asn Pro Leu Arg Ala Arg Pro Thr 130 135 140 Lys Phe Val Ser Lys Phe Ile Ile Gly Gly Ile Trp Met Leu Ala Leu 145 150 155 160 Leu Phe Ala Val Pro Phe Ala Ile Ala Phe Arg Val Glu Glu Leu Thr 165 170 175 Glu Arg Phe Arg Glu Asn Asn Glu Thr Tyr Asn Val Thr Arg Pro Phe 180 185 190 Cys Met Asn Lys Asn Leu Ser Asp Asp Gln Leu Gln Ser Phe Arg Tyr 195 200 205 Thr Leu Val Phe Val Gln Tyr Leu Val Pro Phe Cys Val Ile Ser Phe 210 215 220 Val Tyr Ile Gln Met Ala Val Arg Leu Trp Gly Thr Arg Ala Pro Gly 225 230 235 240 Asn Ala Gln Asp Ser Arg Asp Ile Thr Leu Leu Lys Asn Lys Lys Lys 245 250 255 Val Ile Lys Met Leu Ile Ile Val Val Ile Ile Phe Gly Leu Cys Trp 260 265 270 Leu Pro Leu Gln Leu Tyr Asn Ile Leu Tyr Val Thr Ile Pro Glu Ile 275 280 285 Asn Asp Tyr His Phe Ile Ser Ile Val Trp Phe Cys Cys Asp Trp Leu 290 295 300 Ala Met Ser Asn Ser Cys Tyr Asn Pro Phe Ile Tyr Gly Ile Tyr Asn 305 310 315 320 Glu Lys Phe Lys Arg Glu Phe Asn Lys Arg Phe Ala Ala Cys Phe Cys 325 330 335 Lys Phe Lys Thr Ser Met Asp Ala His Glu Arg Thr Phe Ser Met His 340 345 350 Thr Arg Ala Ser Ser Ile Arg Ser Thr Tyr Ala Asn Ser Ser Met Arg 355 360 365 Ile Arg Ser Asn Leu Phe Gly Pro Ala Arg Gly Gly Val Asn Asn Gly 370 375 380 Lys Pro Gly Leu His Met Pro Arg Val His Gly Ser Gly Ala Asn Ser 385 390 395 400 Gly Ile Tyr Asn Gly Ser Ser Gly Gln Asn Asn Asn Val Asn Gly Gln 405 410 415 His His Gln His Gln Ser Val Val Thr Phe Ala Ala Thr Pro Gly Val 420 425 430 Ser Ala Pro Gly Val Gly Val Ala Met Pro Pro Trp Arg Arg Asn Asn 435 440 445 Phe Lys Pro Leu His Pro Asn Val Ile Glu Cys Glu Asp Asp Val Ala 450 455 460 Leu Met Glu Leu Pro Ser Thr Thr Pro Pro Ser Glu Glu Leu Ala Ser 465 470 475 480 Gly Ala Gly Val Gln Leu Ala Leu Leu Ser Arg Glu Ser Ser Ser Cys 485 490 495 Ile Cys Glu Gln Glu Phe Gly Ser Gln Thr Glu Cys Asp Gly Thr Cys 500 505 510 Ile Leu Ser Glu Val Ser Arg Val His Leu Pro Gly Ser Gln Ala Lys 515 520 525 Asp Lys Asp Ala Gly Lys Ser Leu Trp Gln Pro Leu 530 535 540 <210> SEQ ID NO 3 <211> LENGTH: 1050 <212> TYPE: DNA <213> ORGANISM: Drosophila melanogaster <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(1047) <221> NAME/KEY: n <222> LOCATION: 1050 <223> OTHER INFORMATION: n is a or g or c or t/u, unknown, or other <400> SEQUENCE: 3 atg ggt ttt ggg cta ggt cag ttg cgt tta cag agg gga aac acg aat 48 Met Gly Phe Gly Leu Gly Gln Leu Arg Leu Gln Arg Gly Asn Thr Asn 1 5 10 15 tat act gca gta aat gct caa cga agt tta cct tgc caa tca ttg tat 96 Tyr Thr Ala Val Asn Ala Gln Arg Ser Leu Pro Cys Gln Ser Leu Tyr 20 25 30 att ctc aat tgt tat ttc tta cag att tta caa tgt ccc agc tcg ttc 144 Ile Leu Asn Cys Tyr Phe Leu Gln Ile Leu Gln Cys Pro Ser Ser Phe 35 40 45 gat tcg gtc ctg tgc tgg cca cgc aca aac gcc ggc agt ctg gct gta 192 Asp Ser Val Leu Cys Trp Pro Arg Thr Asn Ala Gly Ser Leu Ala Val 50 55 60 cta ccc tgt ttc gag gaa ttc aag ggc gtg cac tac gac acc aca gac 240 Leu Pro Cys Phe Glu Glu Phe Lys Gly Val His Tyr Asp Thr Thr Asp 65 70 75 80 aat gcc acc cgc ttt tgc ttt cca aac gga acg tgg gat cac tat tcg 288 Asn Ala Thr Arg Phe Cys Phe Pro Asn Gly Thr Trp Asp His Tyr Ser 85 90 95 gac tat gac cgc tgt cac cag aac tcg ggc tcc ata ccg gtg gtg ccc 336 Asp Tyr Asp Arg Cys His Gln Asn Ser Gly Ser Ile Pro Val Val Pro 100 105 110 gac ttc tca ccc aac gtc gaa ctg ccg gcc atc ata tat gcc ggc ggt 384 Asp Phe Ser Pro Asn Val Glu Leu Pro Ala Ile Ile Tyr Ala Gly Gly 115 120 125 tat ttc ctg agc ttc gcc acc ttg gtg gtg gct ctc atc ata ttc ctc 432 Tyr Phe Leu Ser Phe Ala Thr Leu Val Val Ala Leu Ile Ile Phe Leu 130 135 140 agc ttt aaa gat ctt cgt tgc ctg cga aac acc att cat gcc aat ttg 480 Ser Phe Lys Asp Leu Arg Cys Leu Arg Asn Thr Ile His Ala Asn Leu 145 150 155 160 ttc ctc acc tac atc aca tcc gca ctc ctc tgg ata ctc aca ctg ttc 528 Phe Leu Thr Tyr Ile Thr Ser Ala Leu Leu Trp Ile Leu Thr Leu Phe 165 170 175 ctg caa gtg tac ttt tac cta acc aac ttt ttc tgg atg ttt gtg gag 576 Leu Gln Val Tyr Phe Tyr Leu Thr Asn Phe Phe Trp Met Phe Val Glu 180 185 190 ggc ctc tat ctg tac acg ctg gtg gtg caa aca ttc tcc agt gat aac 624 Gly Leu Tyr Leu Tyr Thr Leu Val Val Gln Thr Phe Ser Ser Asp Asn 195 200 205 att agc ttt att atc tac gcc ctc atc ggc tgg ggc tgt cca gcc gta 672 Ile Ser Phe Ile Ile Tyr Ala Leu Ile Gly Trp Gly Cys Pro Ala Val 210 215 220 tgc att ttg gtg tgg tcc att gcc aag gca ttt gct ccg cat ctc gag 720 Cys Ile Leu Val Trp Ser Ile Ala Lys Ala Phe Ala Pro His Leu Glu 225 230 235 240 aac gag cac ttc aat ggg gta ctc atc act aaa tta cgt tct gct cat 768 Asn Glu His Phe Asn Gly Val Leu Ile Thr Lys Leu Arg Ser Ala His 245 250 255 acc ctg gaa acg cgg cag tat tac aag gcc tcg aag gcg ctg ctg gtg 816 Thr Leu Glu Thr Arg Gln Tyr Tyr Lys Ala Ser Lys Ala Leu Leu Val 260 265 270 ctg ata cct ctc ttt ggc atc acc tat ctg ttg gtg cta aca ggc ccg 864 Leu Ile Pro Leu Phe Gly Ile Thr Tyr Leu Leu Val Leu Thr Gly Pro 275 280 285 gaa cag ggt atc agt cgt aat ctc ttc gag gcc ata aga gcc ttt ctc 912 Glu Gln Gly Ile Ser Arg Asn Leu Phe Glu Ala Ile Arg Ala Phe Leu 290 295 300 ata agc acg cag ggc ttc ttt gtg gct ctg ttc tac tgt ttc ctt aac 960 Ile Ser Thr Gln Gly Phe Phe Val Ala Leu Phe Tyr Cys Phe Leu Asn 305 310 315 320 tca gag gtg cgc cag acg ctg agg cat gga ttc acc cgg tgg cgg gag 1008 Ser Glu Val Arg Gln Thr Leu Arg His Gly Phe Thr Arg Trp Arg Glu 325 330 335 agc agg aat atc cat cgg aac agt tcc atc aag aat cgc agn 1050 Ser Arg Asn Ile His Arg Asn Ser Ser Ile Lys Asn Arg 340 345 <210> SEQ ID NO 4 <211> LENGTH: 349 <212> TYPE: PRT <213> ORGANISM: Drosophila melanogaster <400> SEQUENCE: 4 Met Gly Phe Gly Leu Gly Gln Leu Arg Leu Gln Arg Gly Asn Thr Asn 1 5 10 15 Tyr Thr Ala Val Asn Ala Gln Arg Ser Leu Pro Cys Gln Ser Leu Tyr 20 25 30 Ile Leu Asn Cys Tyr Phe Leu Gln Ile Leu Gln Cys Pro Ser Ser Phe 35 40 45 Asp Ser Val Leu Cys Trp Pro Arg Thr Asn Ala Gly Ser Leu Ala Val 50 55 60 Leu Pro Cys Phe Glu Glu Phe Lys Gly Val His Tyr Asp Thr Thr Asp 65 70 75 80 Asn Ala Thr Arg Phe Cys Phe Pro Asn Gly Thr Trp Asp His Tyr Ser 85 90 95 Asp Tyr Asp Arg Cys His Gln Asn Ser Gly Ser Ile Pro Val Val Pro 100 105 110 Asp Phe Ser Pro Asn Val Glu Leu Pro Ala Ile Ile Tyr Ala Gly Gly 115 120 125 Tyr Phe Leu Ser Phe Ala Thr Leu Val Val Ala Leu Ile Ile Phe Leu 130 135 140 Ser Phe Lys Asp Leu Arg Cys Leu Arg Asn Thr Ile His Ala Asn Leu 145 150 155 160 Phe Leu Thr Tyr Ile Thr Ser Ala Leu Leu Trp Ile Leu Thr Leu Phe 165 170 175 Leu Gln Val Tyr Phe Tyr Leu Thr Asn Phe Phe Trp Met Phe Val Glu 180 185 190 Gly Leu Tyr Leu Tyr Thr Leu Val Val Gln Thr Phe Ser Ser Asp Asn 195 200 205 Ile Ser Phe Ile Ile Tyr Ala Leu Ile Gly Trp Gly Cys Pro Ala Val 210 215 220 Cys Ile Leu Val Trp Ser Ile Ala Lys Ala Phe Ala Pro His Leu Glu 225 230 235 240 Asn Glu His Phe Asn Gly Val Leu Ile Thr Lys Leu Arg Ser Ala His 245 250 255 Thr Leu Glu Thr Arg Gln Tyr Tyr Lys Ala Ser Lys Ala Leu Leu Val 260 265 270 Leu Ile Pro Leu Phe Gly Ile Thr Tyr Leu Leu Val Leu Thr Gly Pro 275 280 285 Glu Gln Gly Ile Ser Arg Asn Leu Phe Glu Ala Ile Arg Ala Phe Leu 290 295 300 Ile Ser Thr Gln Gly Phe Phe Val Ala Leu Phe Tyr Cys Phe Leu Asn 305 310 315 320 Ser Glu Val Arg Gln Thr Leu Arg His Gly Phe Thr Arg Trp Arg Glu 325 330 335 Ser Arg Asn Ile His Arg Asn Ser Ser Ile Lys Asn Arg 340 345 <210> SEQ ID NO 5 <211> LENGTH: 1113 <212> TYPE: DNA <213> ORGANISM: Drosophila melanogaster <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(1110) <221> NAME/KEY: n <222> LOCATION: 1113 <223> OTHER INFORMATION: n is a or g or c or t/u, unknown, or other <400> SEQUENCE: 5 atg agt gac cac aac cac atc gat tcg gtg aac gcc agc ggg agt gat 48 Met Ser Asp His Asn His Ile Asp Ser Val Asn Ala Ser Gly Ser Asp 1 5 10 15 ccg ctc ctg gat ctg cac aac cta gat ggc atc ggt gag agc gtg gag 96 Pro Leu Leu Asp Leu His Asn Leu Asp Gly Ile Gly Glu Ser Val Glu 20 25 30 ttg cag tgc ctg gtg cag gag cac atc gag gca tcc acc tat ggc aac 144 Leu Gln Cys Leu Val Gln Glu His Ile Glu Ala Ser Thr Tyr Gly Asn 35 40 45 gat agt ggc cac tgc ctc acc cag ttc gac tcg atc ctg tgc tgg ccg 192 Asp Ser Gly His Cys Leu Thr Gln Phe Asp Ser Ile Leu Cys Trp Pro 50 55 60 agg aca gct cgc ggt acc ctg gcg gtg ctc cag tgc atg gac gag ttg 240 Arg Thr Ala Arg Gly Thr Leu Ala Val Leu Gln Cys Met Asp Glu Leu 65 70 75 80 cag gga att cat tac gat agc agc aag aat gca acg agg ttc tgc cac 288 Gln Gly Ile His Tyr Asp Ser Ser Lys Asn Ala Thr Arg Phe Cys His 85 90 95 gcc aat gga act tgg gag aag tac acc aac tac gat gcc tgc gcc cac 336 Ala Asn Gly Thr Trp Glu Lys Tyr Thr Asn Tyr Asp Ala Cys Ala His 100 105 110 ctg ccc gcc cca gaa tcc gtg ccg gag ttc gag gtc atc gtg gag ctg 384 Leu Pro Ala Pro Glu Ser Val Pro Glu Phe Glu Val Ile Val Glu Leu 115 120 125 ccc acc att atc tac tac att gga tac acc ctc agc ctg gta tcg ctc 432 Pro Thr Ile Ile Tyr Tyr Ile Gly Tyr Thr Leu Ser Leu Val Ser Leu 130 135 140 tcg ctg gcg ctg att gtt ttc gcc tac ttc aag gag ctg cgt tgc ctg 480 Ser Leu Ala Leu Ile Val Phe Ala Tyr Phe Lys Glu Leu Arg Cys Leu 145 150 155 160 cgc aac acc atc cac gcc aac ttg ttc ttc acg tac atc atg tcg gct 528 Arg Asn Thr Ile His Ala Asn Leu Phe Phe Thr Tyr Ile Met Ser Ala 165 170 175 ttg ttc tgg ata ctc ttg tta tcc gtc cag atc tcc atc cga agt gga 576 Leu Phe Trp Ile Leu Leu Leu Ser Val Gln Ile Ser Ile Arg Ser Gly 180 185 190 gtg ggc agc tgc att gct ctg atc acc ctg ttc cac ttc ttc acc ctg 624 Val Gly Ser Cys Ile Ala Leu Ile Thr Leu Phe His Phe Phe Thr Leu 195 200 205 acc aac ttc ttt tgg atg ctg gtc gag ggt ttg tac ctg tac atg ctg 672 Thr Asn Phe Phe Trp Met Leu Val Glu Gly Leu Tyr Leu Tyr Met Leu 210 215 220 gtg gtt aag act ttc tcc ggg gac aat tta cgc ttt aat atc tac gcc 720 Val Val Lys Thr Phe Ser Gly Asp Asn Leu Arg Phe Asn Ile Tyr Ala 225 230 235 240 tcc ata ggc tgg ggt ggc ccg gcc ttg ttt gtt gtc acc tgg gct gtg 768 Ser Ile Gly Trp Gly Gly Pro Ala Leu Phe Val Val Thr Trp Ala Val 245 250 255 gcc aag agt ctg acg gtc acc tac agc acc ccc gaa aag gtt cta atc 816 Ala Lys Ser Leu Thr Val Thr Tyr Ser Thr Pro Glu Lys Val Leu Ile 260 265 270 aca aag ctg cgc tcg gcc aat aca gtg gag act cgt cag tat agg aaa 864 Thr Lys Leu Arg Ser Ala Asn Thr Val Glu Thr Arg Gln Tyr Arg Lys 275 280 285 gct gct aag gca ctg ctg gtg cta atc cca ctt ttt ggc atc acc tac 912 Ala Ala Lys Ala Leu Leu Val Leu Ile Pro Leu Phe Gly Ile Thr Tyr 290 295 300 ctg gtg gtg ctg gct ggt ccc tcg gaa tct ggc cta atg gga cac atg 960 Leu Val Val Leu Ala Gly Pro Ser Glu Ser Gly Leu Met Gly His Met 305 310 315 320 ttt gcc gtc ctg cga gcg gta tta ctc agc act cag gga ttc tcg gtg 1008 Phe Ala Val Leu Arg Ala Val Leu Leu Ser Thr Gln Gly Phe Ser Val 325 330 335 tcg ctg ttc tac tgt ttc ctc aac tcg gag gtg cga aat gca ctg aga 1056 Ser Leu Phe Tyr Cys Phe Leu Asn Ser Glu Val Arg Asn Ala Leu Arg 340 345 350 cac cac att tcc acg tgg cgg gac acg cgc acc att cag ctt aac cag 1104 His His Ile Ser Thr Trp Arg Asp Thr Arg Thr Ile Gln Leu Asn Gln 355 360 365 aac cga cgn 1113 Asn Arg 370 <210> SEQ ID NO 6 <211> LENGTH: 370 <212> TYPE: PRT <213> ORGANISM: Drosophila melanogaster <400> SEQUENCE: 6 Met Ser Asp His Asn His Ile Asp Ser Val Asn Ala Ser Gly Ser Asp 1 5 10 15 Pro Leu Leu Asp Leu His Asn Leu Asp Gly Ile Gly Glu Ser Val Glu 20 25 30 Leu Gln Cys Leu Val Gln Glu His Ile Glu Ala Ser Thr Tyr Gly Asn 35 40 45 Asp Ser Gly His Cys Leu Thr Gln Phe Asp Ser Ile Leu Cys Trp Pro 50 55 60 Arg Thr Ala Arg Gly Thr Leu Ala Val Leu Gln Cys Met Asp Glu Leu 65 70 75 80 Gln Gly Ile His Tyr Asp Ser Ser Lys Asn Ala Thr Arg Phe Cys His 85 90 95 Ala Asn Gly Thr Trp Glu Lys Tyr Thr Asn Tyr Asp Ala Cys Ala His 100 105 110 Leu Pro Ala Pro Glu Ser Val Pro Glu Phe Glu Val Ile Val Glu Leu 115 120 125 Pro Thr Ile Ile Tyr Tyr Ile Gly Tyr Thr Leu Ser Leu Val Ser Leu 130 135 140 Ser Leu Ala Leu Ile Val Phe Ala Tyr Phe Lys Glu Leu Arg Cys Leu 145 150 155 160 Arg Asn Thr Ile His Ala Asn Leu Phe Phe Thr Tyr Ile Met Ser Ala 165 170 175 Leu Phe Trp Ile Leu Leu Leu Ser Val Gln Ile Ser Ile Arg Ser Gly 180 185 190 Val Gly Ser Cys Ile Ala Leu Ile Thr Leu Phe His Phe Phe Thr Leu 195 200 205 Thr Asn Phe Phe Trp Met Leu Val Glu Gly Leu Tyr Leu Tyr Met Leu 210 215 220 Val Val Lys Thr Phe Ser Gly Asp Asn Leu Arg Phe Asn Ile Tyr Ala 225 230 235 240 Ser Ile Gly Trp Gly Gly Pro Ala Leu Phe Val Val Thr Trp Ala Val 245 250 255 Ala Lys Ser Leu Thr Val Thr Tyr Ser Thr Pro Glu Lys Val Leu Ile 260 265 270 Thr Lys Leu Arg Ser Ala Asn Thr Val Glu Thr Arg Gln Tyr Arg Lys 275 280 285 Ala Ala Lys Ala Leu Leu Val Leu Ile Pro Leu Phe Gly Ile Thr Tyr 290 295 300 Leu Val Val Leu Ala Gly Pro Ser Glu Ser Gly Leu Met Gly His Met 305 310 315 320 Phe Ala Val Leu Arg Ala Val Leu Leu Ser Thr Gln Gly Phe Ser Val 325 330 335 Ser Leu Phe Tyr Cys Phe Leu Asn Ser Glu Val Arg Asn Ala Leu Arg 340 345 350 His His Ile Ser Thr Trp Arg Asp Thr Arg Thr Ile Gln Leu Asn Gln 355 360 365 Asn Arg 370 <210> SEQ ID NO 7 <211> LENGTH: 1557 <212> TYPE: DNA <213> ORGANISM: Drosophila melanogaster <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(1554) <400> SEQUENCE: 7 atg gcc aac tta agc tgg ctg agc acc atc acc acc acc tcc tcc tcc 48 Met Ala Asn Leu Ser Trp Leu Ser Thr Ile Thr Thr Thr Ser Ser Ser 1 5 10 15 atc agc acc agc cag ctg cca ttg gtc agc aca acc aac tgg agc cta 96 Ile Ser Thr Ser Gln Leu Pro Leu Val Ser Thr Thr Asn Trp Ser Leu 20 25 30 acg tcg ccg gga act act agc gct atc ttg gcg gat gtg gct gca tcg 144 Thr Ser Pro Gly Thr Thr Ser Ala Ile Leu Ala Asp Val Ala Ala Ser 35 40 45 gat gag gat agg agc ggc ggg atc att cac aac cag ttc gtg caa atc 192 Asp Glu Asp Arg Ser Gly Gly Ile Ile His Asn Gln Phe Val Gln Ile 50 55 60 ttc ttc tac gtc ctg tac gcc acg gtc ttt gtc ctg ggt gtc ttc gga 240 Phe Phe Tyr Val Leu Tyr Ala Thr Val Phe Val Leu Gly Val Phe Gly 65 70 75 80 aat gtc ctg gtt tgc tac gta gtt ctg agg aat cgg gcc atg cag act 288 Asn Val Leu Val Cys Tyr Val Val Leu Arg Asn Arg Ala Met Gln Thr 85 90 95 gtg acc aat ata ttc atc acg aat ctg gcc ctg tcg gac ata ttg ctc 336 Val Thr Asn Ile Phe Ile Thr Asn Leu Ala Leu Ser Asp Ile Leu Leu 100 105 110 tgc gtc ctg gcg gtg cca ttt act ccg ctt tac acg ttc atg ggt cgc 384 Cys Val Leu Ala Val Pro Phe Thr Pro Leu Tyr Thr Phe Met Gly Arg 115 120 125 tgg gcc ttc ggc agg agt ctg tgc cat ctg gtg tcc ttt gcc cag gga 432 Trp Ala Phe Gly Arg Ser Leu Cys His Leu Val Ser Phe Ala Gln Gly 130 135 140 tgc agc atc tac ata tcc acg ctg acc ctc acc tcg att gcc atc gat 480 Cys Ser Ile Tyr Ile Ser Thr Leu Thr Leu Thr Ser Ile Ala Ile Asp 145 150 155 160 cgg tac ttc gtt atc ata tac ccc ttc cat ccg cgc atg aag ctc tcc 528 Arg Tyr Phe Val Ile Ile Tyr Pro Phe His Pro Arg Met Lys Leu Ser 165 170 175 acc tgc atc ggg atc ata gtg agc atc tgg gtg ata gcc ctg ctg gcc 576 Thr Cys Ile Gly Ile Ile Val Ser Ile Trp Val Ile Ala Leu Leu Ala 180 185 190 acc gtt ccc tac ggc atg tac atg aag atg acc aac gag ctg gtg aac 624 Thr Val Pro Tyr Gly Met Tyr Met Lys Met Thr Asn Glu Leu Val Asn 195 200 205 gga acg cag aca ggc aac gag acc ctg gtg gag gcc act cta atg cta 672 Gly Thr Gln Thr Gly Asn Glu Thr Leu Val Glu Ala Thr Leu Met Leu 210 215 220 aac gga agc ttt gtg gcc cag gga tca gga ttc atc gag gcg ccg gac 720 Asn Gly Ser Phe Val Ala Gln Gly Ser Gly Phe Ile Glu Ala Pro Asp 225 230 235 240 tct acc tcg gcc acc cag gcc tat atg cag gtg atg acc gcc gga tca 768 Ser Thr Ser Ala Thr Gln Ala Tyr Met Gln Val Met Thr Ala Gly Ser 245 250 255 acg gga ccg gag atg ccc tat gtg cgg gtg tac tgc gag gag aac tgg 816 Thr Gly Pro Glu Met Pro Tyr Val Arg Val Tyr Cys Glu Glu Asn Trp 260 265 270 cca tcg gag cag tac cgg aag gtg ttc ggt gcc atc aca acc act ctg 864 Pro Ser Glu Gln Tyr Arg Lys Val Phe Gly Ala Ile Thr Thr Thr Leu 275 280 285 cag ttt gtg ctg ccc ttc ttc atc atc tcg att tgc tac gtg tgg ata 912 Gln Phe Val Leu Pro Phe Phe Ile Ile Ser Ile Cys Tyr Val Trp Ile 290 295 300 tcg gtg aag cta aac cag cgg gcc agg gcc aag ccg gga tcg aaa tcc 960 Ser Val Lys Leu Asn Gln Arg Ala Arg Ala Lys Pro Gly Ser Lys Ser 305 310 315 320 tcg aga cgg gag gag gcg gat cgg gat cgc aag aag cgc acc aac cgc 1008 Ser Arg Arg Glu Glu Ala Asp Arg Asp Arg Lys Lys Arg Thr Asn Arg 325 330 335 atg ctc atc gcc atg gtg gcg gta ttc gga ctc agc tgg ctg ccc atc 1056 Met Leu Ile Ala Met Val Ala Val Phe Gly Leu Ser Trp Leu Pro Ile 340 345 350 aat gtg gtc aac ata ttc gat gac ttc gat gac aag tcc aac gag tgg 1104 Asn Val Val Asn Ile Phe Asp Asp Phe Asp Asp Lys Ser Asn Glu Trp 355 360 365 cgc ttc tac atc cta ttc ttc ttt gtg gcc cac tct att gcc atg agc 1152 Arg Phe Tyr Ile Leu Phe Phe Phe Val Ala His Ser Ile Ala Met Ser 370 375 380 tcc acc tgc tac aat ccc ttc ctg tac gcc tgg ctg aac gag aac ttc 1200 Ser Thr Cys Tyr Asn Pro Phe Leu Tyr Ala Trp Leu Asn Glu Asn Phe 385 390 395 400 cgc aag gag ttc aag cac gtg ctg ccc tgc ttt aat ccc tcg aac aac 1248 Arg Lys Glu Phe Lys His Val Leu Pro Cys Phe Asn Pro Ser Asn Asn 405 410 415 aac atc atc aac atc acc agg ggc tat aat cgg agt gat cgg aac acc 1296 Asn Ile Ile Asn Ile Thr Arg Gly Tyr Asn Arg Ser Asp Arg Asn Thr 420 425 430 tgt ggt ccg cga ctg cat cat ggc aag ggg gat ggt ggc atg ggc ggt 1344 Cys Gly Pro Arg Leu His His Gly Lys Gly Asp Gly Gly Met Gly Gly 435 440 445 ggc agt ctg gac gcc gac gac cag gac gag aac ggc atc acc cag gag 1392 Gly Ser Leu Asp Ala Asp Asp Gln Asp Glu Asn Gly Ile Thr Gln Glu 450 455 460 acc tgt ctg ccc aag gag aag ctg ctg att atc ccc agg gag ccg act 1440 Thr Cys Leu Pro Lys Glu Lys Leu Leu Ile Ile Pro Arg Glu Pro Thr 465 470 475 480 tac ggc aat ggc acg ggt gcc gtg tcg cca atc ctt agc ggg cgc ggc 1488 Tyr Gly Asn Gly Thr Gly Ala Val Ser Pro Ile Leu Ser Gly Arg Gly 485 490 495 att aac gcc gcc ctg gtg cac ggt ggc gac cat cag atg cac cag ctg 1536 Ile Asn Ala Ala Leu Val His Gly Gly Asp His Gln Met His Gln Leu 500 505 510 cag ccg tca cac cat caa cag 1557 Gln Pro Ser His His Gln 515 <210> SEQ ID NO 8 <211> LENGTH: 518 <212> TYPE: PRT <213> ORGANISM: Drosophila melanogaster <400> SEQUENCE: 8 Met Ala Asn Leu Ser Trp Leu Ser Thr Ile Thr Thr Thr Ser Ser Ser 1 5 10 15 Ile Ser Thr Ser Gln Leu Pro Leu Val Ser Thr Thr Asn Trp Ser Leu 20 25 30 Thr Ser Pro Gly Thr Thr Ser Ala Ile Leu Ala Asp Val Ala Ala Ser 35 40 45 Asp Glu Asp Arg Ser Gly Gly Ile Ile His Asn Gln Phe Val Gln Ile 50 55 60 Phe Phe Tyr Val Leu Tyr Ala Thr Val Phe Val Leu Gly Val Phe Gly 65 70 75 80 Asn Val Leu Val Cys Tyr Val Val Leu Arg Asn Arg Ala Met Gln Thr 85 90 95 Val Thr Asn Ile Phe Ile Thr Asn Leu Ala Leu Ser Asp Ile Leu Leu 100 105 110 Cys Val Leu Ala Val Pro Phe Thr Pro Leu Tyr Thr Phe Met Gly Arg 115 120 125 Trp Ala Phe Gly Arg Ser Leu Cys His Leu Val Ser Phe Ala Gln Gly 130 135 140 Cys Ser Ile Tyr Ile Ser Thr Leu Thr Leu Thr Ser Ile Ala Ile Asp 145 150 155 160 Arg Tyr Phe Val Ile Ile Tyr Pro Phe His Pro Arg Met Lys Leu Ser 165 170 175 Thr Cys Ile Gly Ile Ile Val Ser Ile Trp Val Ile Ala Leu Leu Ala 180 185 190 Thr Val Pro Tyr Gly Met Tyr Met Lys Met Thr Asn Glu Leu Val Asn 195 200 205 Gly Thr Gln Thr Gly Asn Glu Thr Leu Val Glu Ala Thr Leu Met Leu 210 215 220 Asn Gly Ser Phe Val Ala Gln Gly Ser Gly Phe Ile Glu Ala Pro Asp 225 230 235 240 Ser Thr Ser Ala Thr Gln Ala Tyr Met Gln Val Met Thr Ala Gly Ser 245 250 255 Thr Gly Pro Glu Met Pro Tyr Val Arg Val Tyr Cys Glu Glu Asn Trp 260 265 270 Pro Ser Glu Gln Tyr Arg Lys Val Phe Gly Ala Ile Thr Thr Thr Leu 275 280 285 Gln Phe Val Leu Pro Phe Phe Ile Ile Ser Ile Cys Tyr Val Trp Ile 290 295 300 Ser Val Lys Leu Asn Gln Arg Ala Arg Ala Lys Pro Gly Ser Lys Ser 305 310 315 320 Ser Arg Arg Glu Glu Ala Asp Arg Asp Arg Lys Lys Arg Thr Asn Arg 325 330 335 Met Leu Ile Ala Met Val Ala Val Phe Gly Leu Ser Trp Leu Pro Ile 340 345 350 Asn Val Val Asn Ile Phe Asp Asp Phe Asp Asp Lys Ser Asn Glu Trp 355 360 365 Arg Phe Tyr Ile Leu Phe Phe Phe Val Ala His Ser Ile Ala Met Ser 370 375 380 Ser Thr Cys Tyr Asn Pro Phe Leu Tyr Ala Trp Leu Asn Glu Asn Phe 385 390 395 400 Arg Lys Glu Phe Lys His Val Leu Pro Cys Phe Asn Pro Ser Asn Asn 405 410 415 Asn Ile Ile Asn Ile Thr Arg Gly Tyr Asn Arg Ser Asp Arg Asn Thr 420 425 430 Cys Gly Pro Arg Leu His His Gly Lys Gly Asp Gly Gly Met Gly Gly 435 440 445 Gly Ser Leu Asp Ala Asp Asp Gln Asp Glu Asn Gly Ile Thr Gln Glu 450 455 460 Thr Cys Leu Pro Lys Glu Lys Leu Leu Ile Ile Pro Arg Glu Pro Thr 465 470 475 480 Tyr Gly Asn Gly Thr Gly Ala Val Ser Pro Ile Leu Ser Gly Arg Gly 485 490 495 Ile Asn Ala Ala Leu Val His Gly Gly Asp His Gln Met His Gln Leu 500 505 510 Gln Pro Ser His His Gln 515 <210> SEQ ID NO 9 <211> LENGTH: 1404 <212> TYPE: DNA <213> ORGANISM: Drosophila melanogaster <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(1401) <400> SEQUENCE: 9 atg ttt acg tgg ctg atg atg gat gtc ctc cag ttt gtg aaa ggg gaa 48 Met Phe Thr Trp Leu Met Met Asp Val Leu Gln Phe Val Lys Gly Glu 1 5 10 15 atg aca gcc gat tca gag gca aat gcc aca aat tgg tat aac acg aac 96 Met Thr Ala Asp Ser Glu Ala Asn Ala Thr Asn Trp Tyr Asn Thr Asn 20 25 30 gag agc tta tat acc acg gaa ctg aac cat aga tgg att agt ggt agt 144 Glu Ser Leu Tyr Thr Thr Glu Leu Asn His Arg Trp Ile Ser Gly Ser 35 40 45 tcc aca att cag cca gag gag tcc ctt tat ggc act gat ttg ccc acc 192 Ser Thr Ile Gln Pro Glu Glu Ser Leu Tyr Gly Thr Asp Leu Pro Thr 50 55 60 tat caa cat tgc ata gcc acg cgg aat tcc ttt gct gac ttg ttc act 240 Tyr Gln His Cys Ile Ala Thr Arg Asn Ser Phe Ala Asp Leu Phe Thr 65 70 75 80 gtg gtg ctc tac gga ttt gtg tgc att atc gga tta ttt ggc aac acc 288 Val Val Leu Tyr Gly Phe Val Cys Ile Ile Gly Leu Phe Gly Asn Thr 85 90 95 ctg gtg atc tac gtg gtg ttg cgc ttt tcc aaa atg caa acg gtc acg 336 Leu Val Ile Tyr Val Val Leu Arg Phe Ser Lys Met Gln Thr Val Thr 100 105 110 aat ata tat atc ctg aat ctg gcg gtg gca gac gag tgc ttc ctg att 384 Asn Ile Tyr Ile Leu Asn Leu Ala Val Ala Asp Glu Cys Phe Leu Ile 115 120 125 gga ata ccc ttt ctg ctg tac aca atg cga att tgc agc tgg cga ttc 432 Gly Ile Pro Phe Leu Leu Tyr Thr Met Arg Ile Cys Ser Trp Arg Phe 130 135 140 ggg gag ttt atg tgc aaa gcc tac atg gtg agc aca tcc atc acc tcc 480 Gly Glu Phe Met Cys Lys Ala Tyr Met Val Ser Thr Ser Ile Thr Ser 145 150 155 160 ttc acc tcg tcg att ttt ctg ctc atc atg tcc gcg gat cga tat ata 528 Phe Thr Ser Ser Ile Phe Leu Leu Ile Met Ser Ala Asp Arg Tyr Ile 165 170 175 gcg gta tgc cac ccg att tcc tcg cca cga tat cga act ctg cat att 576 Ala Val Cys His Pro Ile Ser Ser Pro Arg Tyr Arg Thr Leu His Ile 180 185 190 gcc aaa gtg gtc tca gcg att gcc tgg tca act tca gcg gtc ctc atg 624 Ala Lys Val Val Ser Ala Ile Ala Trp Ser Thr Ser Ala Val Leu Met 195 200 205 ctg ccc gtg atc ctt tat gcc agc act gtg gag cag gag gat ggc atc 672 Leu Pro Val Ile Leu Tyr Ala Ser Thr Val Glu Gln Glu Asp Gly Ile 210 215 220 aat tac tcg tgc aac ata atg tgg cca gat gcg tac aag aag cat tcg 720 Asn Tyr Ser Cys Asn Ile Met Trp Pro Asp Ala Tyr Lys Lys His Ser 225 230 235 240 ggc acc acc ttc ata ctg tac aca ttt ttc cta gga ttc gcc aca ccg 768 Gly Thr Thr Phe Ile Leu Tyr Thr Phe Phe Leu Gly Phe Ala Thr Pro 245 250 255 ctg tgc ttt atc ctg agt ttc tac tac ttg gtt ata agg aaa ctg cga 816 Leu Cys Phe Ile Leu Ser Phe Tyr Tyr Leu Val Ile Arg Lys Leu Arg 260 265 270 tcg gtg ggt ccc aaa cca gga acg aag tcc aag gag aag agg cgg gct 864 Ser Val Gly Pro Lys Pro Gly Thr Lys Ser Lys Glu Lys Arg Arg Ala 275 280 285 cac agg aag gtc act cga ctg gta ctg acg gtg gcc ctg att cac tcg 912 His Arg Lys Val Thr Arg Leu Val Leu Thr Val Ala Leu Ile His Ser 290 295 300 aat ccc gcg caa agg gac ctc tcc cga ctg gaa ata ctc att ttc cta 960 Asn Pro Ala Gln Arg Asp Leu Ser Arg Leu Glu Ile Leu Ile Phe Leu 305 310 315 320 ctt ctg ggg gca ctg gtt tac tcg aat tcg gcg gtg aat ccc ata ctt 1008 Leu Leu Gly Ala Leu Val Tyr Ser Asn Ser Ala Val Asn Pro Ile Leu 325 330 335 tat gcc ttc cta agt gag aac ttc cgg aag agc ttc ttc aag gcc ttt 1056 Tyr Ala Phe Leu Ser Glu Asn Phe Arg Lys Ser Phe Phe Lys Ala Phe 340 345 350 acc tgt atg aat aag cag gat atc aac gct caa ctc cag ctg gag ccc 1104 Thr Cys Met Asn Lys Gln Asp Ile Asn Ala Gln Leu Gln Leu Glu Pro 355 360 365 agt gtt ttc acc aaa cag ggc agt aaa aag agg ggt ggc tcc aag cgc 1152 Ser Val Phe Thr Lys Gln Gly Ser Lys Lys Arg Gly Gly Ser Lys Arg 370 375 380 ctg ttg acc agc aat ccg cag att cct cca ctg ctg cca ctg aat gcg 1200 Leu Leu Thr Ser Asn Pro Gln Ile Pro Pro Leu Leu Pro Leu Asn Ala 385 390 395 400 ggt aac aac aat tca tcg acc acc aca tcc tcg acc acg aca gcg gaa 1248 Gly Asn Asn Asn Ser Ser Thr Thr Thr Ser Ser Thr Thr Thr Ala Glu 405 410 415 aag acc gga acc acg ggg aca cag aaa tca tgc aat tcc aat ggc aaa 1296 Lys Thr Gly Thr Thr Gly Thr Gln Lys Ser Cys Asn Ser Asn Gly Lys 420 425 430 gtg aca gct ccg ccg gag aat ttg att ata tgt ttg agc gag cag cag 1344 Val Thr Ala Pro Pro Glu Asn Leu Ile Ile Cys Leu Ser Glu Gln Gln 435 440 445 gag gca ttt tgc acc acc gcg agg aga gga tcg ggc gca gtg cag cag 1392 Glu Ala Phe Cys Thr Thr Ala Arg Arg Gly Ser Gly Ala Val Gln Gln 450 455 460 aca gat ttg taa 1404 Thr Asp Leu 465 <210> SEQ ID NO 10 <211> LENGTH: 467 <212> TYPE: PRT <213> ORGANISM: Drosophila melanogaster <400> SEQUENCE: 10 Met Phe Thr Trp Leu Met Met Asp Val Leu Gln Phe Val Lys Gly Glu 1 5 10 15 Met Thr Ala Asp Ser Glu Ala Asn Ala Thr Asn Trp Tyr Asn Thr Asn 20 25 30 Glu Ser Leu Tyr Thr Thr Glu Leu Asn His Arg Trp Ile Ser Gly Ser 35 40 45 Ser Thr Ile Gln Pro Glu Glu Ser Leu Tyr Gly Thr Asp Leu Pro Thr 50 55 60 Tyr Gln His Cys Ile Ala Thr Arg Asn Ser Phe Ala Asp Leu Phe Thr 65 70 75 80 Val Val Leu Tyr Gly Phe Val Cys Ile Ile Gly Leu Phe Gly Asn Thr 85 90 95 Leu Val Ile Tyr Val Val Leu Arg Phe Ser Lys Met Gln Thr Val Thr 100 105 110 Asn Ile Tyr Ile Leu Asn Leu Ala Val Ala Asp Glu Cys Phe Leu Ile 115 120 125 Gly Ile Pro Phe Leu Leu Tyr Thr Met Arg Ile Cys Ser Trp Arg Phe 130 135 140 Gly Glu Phe Met Cys Lys Ala Tyr Met Val Ser Thr Ser Ile Thr Ser 145 150 155 160 Phe Thr Ser Ser Ile Phe Leu Leu Ile Met Ser Ala Asp Arg Tyr Ile 165 170 175 Ala Val Cys His Pro Ile Ser Ser Pro Arg Tyr Arg Thr Leu His Ile 180 185 190 Ala Lys Val Val Ser Ala Ile Ala Trp Ser Thr Ser Ala Val Leu Met 195 200 205 Leu Pro Val Ile Leu Tyr Ala Ser Thr Val Glu Gln Glu Asp Gly Ile 210 215 220 Asn Tyr Ser Cys Asn Ile Met Trp Pro Asp Ala Tyr Lys Lys His Ser 225 230 235 240 Gly Thr Thr Phe Ile Leu Tyr Thr Phe Phe Leu Gly Phe Ala Thr Pro 245 250 255 Leu Cys Phe Ile Leu Ser Phe Tyr Tyr Leu Val Ile Arg Lys Leu Arg 260 265 270 Ser Val Gly Pro Lys Pro Gly Thr Lys Ser Lys Glu Lys Arg Arg Ala 275 280 285 His Arg Lys Val Thr Arg Leu Val Leu Thr Val Ala Leu Ile His Ser 290 295 300 Asn Pro Ala Gln Arg Asp Leu Ser Arg Leu Glu Ile Leu Ile Phe Leu 305 310 315 320 Leu Leu Gly Ala Leu Val Tyr Ser Asn Ser Ala Val Asn Pro Ile Leu 325 330 335 Tyr Ala Phe Leu Ser Glu Asn Phe Arg Lys Ser Phe Phe Lys Ala Phe 340 345 350 Thr Cys Met Asn Lys Gln Asp Ile Asn Ala Gln Leu Gln Leu Glu Pro 355 360 365 Ser Val Phe Thr Lys Gln Gly Ser Lys Lys Arg Gly Gly Ser Lys Arg 370 375 380 Leu Leu Thr Ser Asn Pro Gln Ile Pro Pro Leu Leu Pro Leu Asn Ala 385 390 395 400 Gly Asn Asn Asn Ser Ser Thr Thr Thr Ser Ser Thr Thr Thr Ala Glu 405 410 415 Lys Thr Gly Thr Thr Gly Thr Gln Lys Ser Cys Asn Ser Asn Gly Lys 420 425 430 Val Thr Ala Pro Pro Glu Asn Leu Ile Ile Cys Leu Ser Glu Gln Gln 435 440 445 Glu Ala Phe Cys Thr Thr Ala Arg Arg Gly Ser Gly Ala Val Gln Gln 450 455 460 Thr Asp Leu 465 <210> SEQ ID NO 11 <211> LENGTH: 957 <212> TYPE: DNA <213> ORGANISM: Drosophila melanogaster <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(954) <221> NAME/KEY: n <222> LOCATION: 956, 957 <223> OTHER INFORMATION: n is a or g or c or t/u, unknown, or other <400> SEQUENCE: 11 atg aat ctg ttc gcc tcg ttc gct gcc aat aac tcg ttg tgg ctg gtc 48 Met Asn Leu Phe Ala Ser Phe Ala Ala Asn Asn Ser Leu Trp Leu Val 1 5 10 15 tgg tac ctg ctg gtc atg ccg aat tcg gag cta ctg cat cag agt ccg 96 Trp Tyr Leu Leu Val Met Pro Asn Ser Glu Leu Leu His Gln Ser Pro 20 25 30 atg cgc tgc gtt gcc ctg cac ata acg cta cac tac ttc ctc ctg tcc 144 Met Arg Cys Val Ala Leu His Ile Thr Leu His Tyr Phe Leu Leu Ser 35 40 45 aat tac tcc tgg atg ctc tgc gag gga ttc tat ctg cac acc gtc ctc 192 Asn Tyr Ser Trp Met Leu Cys Glu Gly Phe Tyr Leu His Thr Val Leu 50 55 60 gtc gcc gca ttc att tcc gag aag agg ctg gtc aaa tgg ctc atc gca 240 Val Ala Ala Phe Ile Ser Glu Lys Arg Leu Val Lys Trp Leu Ile Ala 65 70 75 80 ttc ggc tgg ggc tcc ccg gcc atc gtc ata ttc gtc tat agc atg gct 288 Phe Gly Trp Gly Ser Pro Ala Ile Val Ile Phe Val Tyr Ser Met Ala 85 90 95 cgc ggt ctg ggc ggc acg ccc gag gac aat cgt cac tgc tgg atg aac 336 Arg Gly Leu Gly Gly Thr Pro Glu Asp Asn Arg His Cys Trp Met Asn 100 105 110 caa acc aac tac caa aac att ctt atg gtg cct gtg tgt atc tcc atg 384 Gln Thr Asn Tyr Gln Asn Ile Leu Met Val Pro Val Cys Ile Ser Met 115 120 125 ttc ctg aac ctc ctg ttc ctg tgc aac att gtg cga gtg gtc ctt ttg 432 Phe Leu Asn Leu Leu Phe Leu Cys Asn Ile Val Arg Val Val Leu Leu 130 135 140 aaa ctg aat gcc ccg gcc agt att cag ggc agc tgc ggt cca tcg cga 480 Lys Leu Asn Ala Pro Ala Ser Ile Gln Gly Ser Cys Gly Pro Ser Arg 145 150 155 160 acg gtt ttg caa gca ttt cgg gca acg ctg ctt ttg gtt cct ctg ctc 528 Thr Val Leu Gln Ala Phe Arg Ala Thr Leu Leu Leu Val Pro Leu Leu 165 170 175 ggc ctc cag tac atc ctt acg ccc ttt cgt cct gca ccc aaa cat ccc 576 Gly Leu Gln Tyr Ile Leu Thr Pro Phe Arg Pro Ala Pro Lys His Pro 180 185 190 tgg gag aat aca tac gaa atc atc tcg gcg ttt acg gcc tca ttt caa 624 Trp Glu Asn Thr Tyr Glu Ile Ile Ser Ala Phe Thr Ala Ser Phe Gln 195 200 205 ggt ctg tgc gtt gcc att ttg ttc tgc ttt tgc aac ggc gag gtg att 672 Gly Leu Cys Val Ala Ile Leu Phe Cys Phe Cys Asn Gly Glu Val Ile 210 215 220 gcc caa atg aag cgc aag tgg cgg atg atg tgc ttc agc aac cga ccg 720 Ala Gln Met Lys Arg Lys Trp Arg Met Met Cys Phe Ser Asn Arg Pro 225 230 235 240 cgg acc aat tcc tat aca gcc act cag gtc tcg ccc cat cac caa agc 768 Arg Thr Asn Ser Tyr Thr Ala Thr Gln Val Ser Pro His His Gln Ser 245 250 255 cac cag ttg tcc acg gat cag cag aga gct cgc agc cag agc ctg gcg 816 His Gln Leu Ser Thr Asp Gln Gln Arg Ala Arg Ser Gln Ser Leu Ala 260 265 270 agt tcg tcg tcc ttc ctg gaa ggc tgg cgc gac cgg atg ccg ttc ctg 864 Ser Ser Ser Ser Phe Leu Glu Gly Trp Arg Asp Arg Met Pro Phe Leu 275 280 285 aaa cgg cga caa act atc gac cac tcc cgc cag agc cag cca ctc atg 912 Lys Arg Arg Gln Thr Ile Asp His Ser Arg Gln Ser Gln Pro Leu Met 290 295 300 gag gag ggc gga gag acc gtt ggc cag gcc aaa tcc gcg cca gnn 957 Glu Glu Gly Gly Glu Thr Val Gly Gln Ala Lys Ser Ala Pro 305 310 315 <210> SEQ ID NO 12 <211> LENGTH: 318 <212> TYPE: PRT <213> ORGANISM: Drosophila melanogaster <400> SEQUENCE: 12 Met Asn Leu Phe Ala Ser Phe Ala Ala Asn Asn Ser Leu Trp Leu Val 1 5 10 15 Trp Tyr Leu Leu Val Met Pro Asn Ser Glu Leu Leu His Gln Ser Pro 20 25 30 Met Arg Cys Val Ala Leu His Ile Thr Leu His Tyr Phe Leu Leu Ser 35 40 45 Asn Tyr Ser Trp Met Leu Cys Glu Gly Phe Tyr Leu His Thr Val Leu 50 55 60 Val Ala Ala Phe Ile Ser Glu Lys Arg Leu Val Lys Trp Leu Ile Ala 65 70 75 80 Phe Gly Trp Gly Ser Pro Ala Ile Val Ile Phe Val Tyr Ser Met Ala 85 90 95 Arg Gly Leu Gly Gly Thr Pro Glu Asp Asn Arg His Cys Trp Met Asn 100 105 110 Gln Thr Asn Tyr Gln Asn Ile Leu Met Val Pro Val Cys Ile Ser Met 115 120 125 Phe Leu Asn Leu Leu Phe Leu Cys Asn Ile Val Arg Val Val Leu Leu 130 135 140 Lys Leu Asn Ala Pro Ala Ser Ile Gln Gly Ser Cys Gly Pro Ser Arg 145 150 155 160 Thr Val Leu Gln Ala Phe Arg Ala Thr Leu Leu Leu Val Pro Leu Leu 165 170 175 Gly Leu Gln Tyr Ile Leu Thr Pro Phe Arg Pro Ala Pro Lys His Pro 180 185 190 Trp Glu Asn Thr Tyr Glu Ile Ile Ser Ala Phe Thr Ala Ser Phe Gln 195 200 205 Gly Leu Cys Val Ala Ile Leu Phe Cys Phe Cys Asn Gly Glu Val Ile 210 215 220 Ala Gln Met Lys Arg Lys Trp Arg Met Met Cys Phe Ser Asn Arg Pro 225 230 235 240 Arg Thr Asn Ser Tyr Thr Ala Thr Gln Val Ser Pro His His Gln Ser 245 250 255 His Gln Leu Ser Thr Asp Gln Gln Arg Ala Arg Ser Gln Ser Leu Ala 260 265 270 Ser Ser Ser Ser Phe Leu Glu Gly Trp Arg Asp Arg Met Pro Phe Leu 275 280 285 Lys Arg Arg Gln Thr Ile Asp His Ser Arg Gln Ser Gln Pro Leu Met 290 295 300 Glu Glu Gly Gly Glu Thr Val Gly Gln Ala Lys Ser Ala Pro 305 310 315 <210> SEQ ID NO 13 <211> LENGTH: 1401 <212> TYPE: DNA <213> ORGANISM: Drosophila melanogaster <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(1398) <400> SEQUENCE: 13 atg aag gat gtg ccc gac aaa tat gtg acg gca ctc tcg cac ttc ctc 48 Met Lys Asp Val Pro Asp Lys Tyr Val Thr Ala Leu Ser His Phe Leu 1 5 10 15 gac tgg cat tcc aat ggc acg gtt gac atg gag cga ctt agt ggt ccc 96 Asp Trp His Ser Asn Gly Thr Val Asp Met Glu Arg Leu Ser Gly Pro 20 25 30 atc cta aag tcc agc atc aag tcg gtc tat tgg ctg ttt ctc atc cag 144 Ile Leu Lys Ser Ser Ile Lys Ser Val Tyr Trp Leu Phe Leu Ile Gln 35 40 45 tac gca gct ctc gcc cta ctg ggc gtg gtg ctc aat gtg atc atc gtg 192 Tyr Ala Ala Leu Ala Leu Leu Gly Val Val Leu Asn Val Ile Ile Val 50 55 60 gtg tac ata atg tac cat cga ctt tac aag gat gtg acc cat gcg ttc 240 Val Tyr Ile Met Tyr His Arg Leu Tyr Lys Asp Val Thr His Ala Phe 65 70 75 80 atc atc aat ctg gcc cta tgc cat ttt gtc cag tgc gcc ctc gtc ctg 288 Ile Ile Asn Leu Ala Leu Cys His Phe Val Gln Cys Ala Leu Val Leu 85 90 95 ccc gtc tcg ctg atg gtc atg ctc atc cag aac tgg atc ttt ggc cag 336 Pro Val Ser Leu Met Val Met Leu Ile Gln Asn Trp Ile Phe Gly Gln 100 105 110 ttt ctg tgc ttc ttt ctg ccc atg ctg cag tcg aag att ttg gag atc 384 Phe Leu Cys Phe Phe Leu Pro Met Leu Gln Ser Lys Ile Leu Glu Ile 115 120 125 ggc gac cct gtg cac atc tat agc acg aaa aaa caa cga tca aac ctt 432 Gly Asp Pro Val His Ile Tyr Ser Thr Lys Lys Gln Arg Ser Asn Leu 130 135 140 aaa cag cga cag ctt tgg aac att ccc aaa ata ccg tca ttt tcc cag 480 Lys Gln Arg Gln Leu Trp Asn Ile Pro Lys Ile Pro Ser Phe Ser Gln 145 150 155 160 ctt cag gat atg gaa att tca gca ggg agc gac cac gtt tcc cgg gaa 528 Leu Gln Asp Met Glu Ile Ser Ala Gly Ser Asp His Val Ser Arg Glu 165 170 175 caa tgg gtc atc gac ggt ccc aac acg cat gag aag gtg atc atc ctc 576 Gln Trp Val Ile Asp Gly Pro Asn Thr His Glu Lys Val Ile Ile Leu 180 185 190 tca gat cat cca tat gcc act cga gaa cga cgt tca tat gga aac att 624 Ser Asp His Pro Tyr Ala Thr Arg Glu Arg Arg Ser Tyr Gly Asn Ile 195 200 205 cgt ggc gtg gag aac tat tgc gat ccg gtt gcc acc cag gac gaa cga 672 Arg Gly Val Glu Asn Tyr Cys Asp Pro Val Ala Thr Gln Asp Glu Arg 210 215 220 atg gag gcc aat ccg ggc ata gtc ccg aaa gaa gaa gac cct gag cct 720 Met Glu Ala Asn Pro Gly Ile Val Pro Lys Glu Glu Asp Pro Glu Pro 225 230 235 240 tct cca aaa atc acg aat gga ctt ata tat caa ggc acc ttc aat gaa 768 Ser Pro Lys Ile Thr Asn Gly Leu Ile Tyr Gln Gly Thr Phe Asn Glu 245 250 255 gaa ttc gac atg ctg gac aat gag tca aaa gct aaa gca aat gga aac 816 Glu Phe Asp Met Leu Asp Asn Glu Ser Lys Ala Lys Ala Asn Gly Asn 260 265 270 cta caa gat gtt aaa cca gaa gct ccg cag cat cct tta gaa aac acc 864 Leu Gln Asp Val Lys Pro Glu Ala Pro Gln His Pro Leu Glu Asn Thr 275 280 285 gcc ttt cag aat aca ccg ccc agt att ggc gga cag aat aat gaa aac 912 Ala Phe Gln Asn Thr Pro Pro Ser Ile Gly Gly Gln Asn Asn Glu Asn 290 295 300 act tcg gga tac ata gtc aag agg gat gaa atg gca acc ttg atg aat 960 Thr Ser Gly Tyr Ile Val Lys Arg Asp Glu Met Ala Thr Leu Met Asn 305 310 315 320 gat ata gac acg gat ggt atc ttc gat tat ctg aaa ctg cag ttg gac 1008 Asp Ile Asp Thr Asp Gly Ile Phe Asp Tyr Leu Lys Leu Gln Leu Asp 325 330 335 acg cag acg cca acg gag cag caa gac aat aag gag ccc cat ttg ctg 1056 Thr Gln Thr Pro Thr Glu Gln Gln Asp Asn Lys Glu Pro His Leu Leu 340 345 350 acg tcc tca gga gag aag aat aaa tat att ggt gtg gtg tcc ttg cat 1104 Thr Ser Ser Gly Glu Lys Asn Lys Tyr Ile Gly Val Val Ser Leu His 355 360 365 gag gca tgt ccc ttt cca acg ttc gag aag ata gtc aag gat att atc 1152 Glu Ala Cys Pro Phe Pro Thr Phe Glu Lys Ile Val Lys Asp Ile Ile 370 375 380 gag cag gat tgc aag aag ata ata gag acc aag aag atg gtg gat gag 1200 Glu Gln Asp Cys Lys Lys Ile Ile Glu Thr Lys Lys Met Val Asp Glu 385 390 395 400 ctg gtc aag gtg gag gtc aaa aag gag atc gag gag gtg gtc aag cag 1248 Leu Val Lys Val Glu Val Lys Lys Glu Ile Glu Glu Val Val Lys Gln 405 410 415 gag gtc aaa aag gag atc gag gag gtg gtc aag cag gag gtc aaa aag 1296 Glu Val Lys Lys Glu Ile Glu Glu Val Val Lys Gln Glu Val Lys Lys 420 425 430 gag atc gag gag gtg gtc aag aag gag atc aag aag gag atc aag gag 1344 Glu Ile Glu Glu Val Val Lys Lys Glu Ile Lys Lys Glu Ile Lys Glu 435 440 445 gag atc gag aag gag atc cag gcg gag atc gac gat gag atc gtg gaa 1392 Glu Ile Glu Lys Glu Ile Gln Ala Glu Ile Asp Asp Glu Ile Val Glu 450 455 460 gtg gac tag 1401 Val Asp 465 <210> SEQ ID NO 14 <211> LENGTH: 466 <212> TYPE: PRT <213> ORGANISM: Drosophila melanogaster <400> SEQUENCE: 14 Met Lys Asp Val Pro Asp Lys Tyr Val Thr Ala Leu Ser His Phe Leu 1 5 10 15 Asp Trp His Ser Asn Gly Thr Val Asp Met Glu Arg Leu Ser Gly Pro 20 25 30 Ile Leu Lys Ser Ser Ile Lys Ser Val Tyr Trp Leu Phe Leu Ile Gln 35 40 45 Tyr Ala Ala Leu Ala Leu Leu Gly Val Val Leu Asn Val Ile Ile Val 50 55 60 Val Tyr Ile Met Tyr His Arg Leu Tyr Lys Asp Val Thr His Ala Phe 65 70 75 80 Ile Ile Asn Leu Ala Leu Cys His Phe Val Gln Cys Ala Leu Val Leu 85 90 95 Pro Val Ser Leu Met Val Met Leu Ile Gln Asn Trp Ile Phe Gly Gln 100 105 110 Phe Leu Cys Phe Phe Leu Pro Met Leu Gln Ser Lys Ile Leu Glu Ile 115 120 125 Gly Asp Pro Val His Ile Tyr Ser Thr Lys Lys Gln Arg Ser Asn Leu 130 135 140 Lys Gln Arg Gln Leu Trp Asn Ile Pro Lys Ile Pro Ser Phe Ser Gln 145 150 155 160 Leu Gln Asp Met Glu Ile Ser Ala Gly Ser Asp His Val Ser Arg Glu 165 170 175 Gln Trp Val Ile Asp Gly Pro Asn Thr His Glu Lys Val Ile Ile Leu 180 185 190 Ser Asp His Pro Tyr Ala Thr Arg Glu Arg Arg Ser Tyr Gly Asn Ile 195 200 205 Arg Gly Val Glu Asn Tyr Cys Asp Pro Val Ala Thr Gln Asp Glu Arg 210 215 220 Met Glu Ala Asn Pro Gly Ile Val Pro Lys Glu Glu Asp Pro Glu Pro 225 230 235 240 Ser Pro Lys Ile Thr Asn Gly Leu Ile Tyr Gln Gly Thr Phe Asn Glu 245 250 255 Glu Phe Asp Met Leu Asp Asn Glu Ser Lys Ala Lys Ala Asn Gly Asn 260 265 270 Leu Gln Asp Val Lys Pro Glu Ala Pro Gln His Pro Leu Glu Asn Thr 275 280 285 Ala Phe Gln Asn Thr Pro Pro Ser Ile Gly Gly Gln Asn Asn Glu Asn 290 295 300 Thr Ser Gly Tyr Ile Val Lys Arg Asp Glu Met Ala Thr Leu Met Asn 305 310 315 320 Asp Ile Asp Thr Asp Gly Ile Phe Asp Tyr Leu Lys Leu Gln Leu Asp 325 330 335 Thr Gln Thr Pro Thr Glu Gln Gln Asp Asn Lys Glu Pro His Leu Leu 340 345 350 Thr Ser Ser Gly Glu Lys Asn Lys Tyr Ile Gly Val Val Ser Leu His 355 360 365 Glu Ala Cys Pro Phe Pro Thr Phe Glu Lys Ile Val Lys Asp Ile Ile 370 375 380 Glu Gln Asp Cys Lys Lys Ile Ile Glu Thr Lys Lys Met Val Asp Glu 385 390 395 400 Leu Val Lys Val Glu Val Lys Lys Glu Ile Glu Glu Val Val Lys Gln 405 410 415 Glu Val Lys Lys Glu Ile Glu Glu Val Val Lys Gln Glu Val Lys Lys 420 425 430 Glu Ile Glu Glu Val Val Lys Lys Glu Ile Lys Lys Glu Ile Lys Glu 435 440 445 Glu Ile Glu Lys Glu Ile Gln Ala Glu Ile Asp Asp Glu Ile Val Glu 450 455 460 Val Asp 465 <210> SEQ ID NO 15 <211> LENGTH: 2001 <212> TYPE: DNA <213> ORGANISM: Drosophila melanogaster <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(1998) <400> SEQUENCE: 15 atg gcc aat ctg cgt ccc ctg agc gcc gaa ctt cgt cgc att gct gaa 48 Met Ala Asn Leu Arg Pro Leu Ser Ala Glu Leu Arg Arg Ile Ala Glu 1 5 10 15 acg gag cta aac gaa gtg gag gag cga gtg ccc gcg gat ctg aaa gct 96 Thr Glu Leu Asn Glu Val Glu Glu Arg Val Pro Ala Asp Leu Lys Ala 20 25 30 ctt cgg gat tgg ttg gcc aag caa cct cat ctg agg gcc cgc cag gat 144 Leu Arg Asp Trp Leu Ala Lys Gln Pro His Leu Arg Ala Arg Gln Asp 35 40 45 gac cag ttc cta gtt ggc ttc ttg cga ggc tgc aag ttt agc ctg gag 192 Asp Gln Phe Leu Val Gly Phe Leu Arg Gly Cys Lys Phe Ser Leu Glu 50 55 60 aag acc aag tcc aag ctg gat cac ttt tat act att aag acg ctt atg 240 Lys Thr Lys Ser Lys Leu Asp His Phe Tyr Thr Ile Lys Thr Leu Met 65 70 75 80 cct gag ctc ttc ggc aaa aga ttg gtg gac gaa agg aac cta atc ttg 288 Pro Glu Leu Phe Gly Lys Arg Leu Val Asp Glu Arg Asn Leu Ile Leu 85 90 95 tgc aga tct gga acc tat gtt cga ttg ccc aaa cct tgg gga acc gat 336 Cys Arg Ser Gly Thr Tyr Val Arg Leu Pro Lys Pro Trp Gly Thr Asp 100 105 110 ggc ccc cgc ctg cag ctt acg aac tat gag aaa ttc gac cct aag gaa 384 Gly Pro Arg Leu Gln Leu Thr Asn Tyr Glu Lys Phe Asp Pro Lys Glu 115 120 125 ttc aag tta ttg gat ctc ttc cgc tac caa acc atg ata acg gaa cag 432 Phe Lys Leu Leu Asp Leu Phe Arg Tyr Gln Thr Met Ile Thr Glu Gln 130 135 140 tca atc cgt gag gat gac cac agc aac att agc ggc tac gtc gag atc 480 Ser Ile Arg Glu Asp Asp His Ser Asn Ile Ser Gly Tyr Val Glu Ile 145 150 155 160 gtt gac atg gcc aaa atg agc ctc agt ttt ctg gcc caa ctg gat ttc 528 Val Asp Met Ala Lys Met Ser Leu Ser Phe Leu Ala Gln Leu Asp Phe 165 170 175 acg ctc atc aaa agg atg gga ata ttc gct gag aag gca cag ccc act 576 Thr Leu Ile Lys Arg Met Gly Ile Phe Ala Glu Lys Ala Gln Pro Thr 180 185 190 cgc ttg aaa gga gtc cat ctg atc aat tgc ccc aag gag gga gtg gcg 624 Arg Leu Lys Gly Val His Leu Ile Asn Cys Pro Lys Glu Gly Val Ala 195 200 205 tta ctg aat ttg gcc aag agc cta atg ccc agc aag ctc cag cag cgg 672 Leu Leu Asn Leu Ala Lys Ser Leu Met Pro Ser Lys Leu Gln Gln Arg 210 215 220 ttt cac gtg tat aaa aat ctc gag caa tta aac gag gtg ata cca cgc 720 Phe His Val Tyr Lys Asn Leu Glu Gln Leu Asn Glu Val Ile Pro Arg 225 230 235 240 gaa tac ctg ccg gaa gaa tat ggt ggc aac aat gga cgt ata gcc gac 768 Glu Tyr Leu Pro Glu Glu Tyr Gly Gly Asn Asn Gly Arg Ile Ala Asp 245 250 255 att cag gcg gaa gcg gag aag aaa ttg ctg tcc tat gag agc tat ttt 816 Ile Gln Ala Glu Ala Glu Lys Lys Leu Leu Ser Tyr Glu Ser Tyr Phe 260 265 270 gct gag gat tcc cag tac gga ttt gac ttc ggc aaa tgg gac ttc cca 864 Ala Glu Asp Ser Gln Tyr Gly Phe Asp Phe Gly Lys Trp Asp Phe Pro 275 280 285 gcc gag cgc atc tgg ctg cac aag ccc aat ggg gag atc acc tgg aag 912 Ala Glu Arg Ile Trp Leu His Lys Pro Asn Gly Glu Ile Thr Trp Lys 290 295 300 atc tgc act ttt cta cca ctg att gct ttt ggt ctg tat gga aac ttc 960 Ile Cys Thr Phe Leu Pro Leu Ile Ala Phe Gly Leu Tyr Gly Asn Phe 305 310 315 320 agc atg gtt tat gtg ata gcc acc aac cgt tct ttg cgc tcg ccc acc 1008 Ser Met Val Tyr Val Ile Ala Thr Asn Arg Ser Leu Arg Ser Pro Thr 325 330 335 aac ttg att att gca aat atg gcc gtt gcg gat cta ctg acc ctg gcc 1056 Asn Leu Ile Ile Ala Asn Met Ala Val Ala Asp Leu Leu Thr Leu Ala 340 345 350 att tgt cct gcc atg ttc atg gtg aac gac ttc tat cag aac tac cag 1104 Ile Cys Pro Ala Met Phe Met Val Asn Asp Phe Tyr Gln Asn Tyr Gln 355 360 365 ttg gga tgc gtg ggc tgc aag ctg gag ggc ttt ttg gtg gtg gtc ttc 1152 Leu Gly Cys Val Gly Cys Lys Leu Glu Gly Phe Leu Val Val Val Phe 370 375 380 ctc atc aca gcc gtg ctc aat ctc tcg gta gtc agc tac gat cgt ctc 1200 Leu Ile Thr Ala Val Leu Asn Leu Ser Val Val Ser Tyr Asp Arg Leu 385 390 395 400 acg gcc atc gtg ctg cca atg gag acg cgc ctc acc ata agg ggc gtc 1248 Thr Ala Ile Val Leu Pro Met Glu Thr Arg Leu Thr Ile Arg Gly Val 405 410 415 cag ata gtg gtg gtc tgc acc tgg gtc tcg ggt atc cta ttg gca tca 1296 Gln Ile Val Val Val Cys Thr Trp Val Ser Gly Ile Leu Leu Ala Ser 420 425 430 cca ttg gct ttc tat cgc tct tac agg gtg cga gtg tgg aag aac ttt 1344 Pro Leu Ala Phe Tyr Arg Ser Tyr Arg Val Arg Val Trp Lys Asn Phe 435 440 445 acg gag cga tat tgc aag gag aac acc tct gtg ctg ccc aag tac tgg 1392 Thr Glu Arg Tyr Cys Lys Glu Asn Thr Ser Val Leu Pro Lys Tyr Trp 450 455 460 tat gtt ctg atc acc att ctg gtg tgg ctg cca tta ggc atc atg ctt 1440 Tyr Val Leu Ile Thr Ile Leu Val Trp Leu Pro Leu Gly Ile Met Leu 465 470 475 480 atc tgc tac ata gcc ata ttt tat aag ctt gat cgg tat gaa aag cgg 1488 Ile Cys Tyr Ile Ala Ile Phe Tyr Lys Leu Asp Arg Tyr Glu Lys Arg 485 490 495 gtc cta agt cgc gag aac ccg ctg aca gtg agc tat aaa cgc agc gtg 1536 Val Leu Ser Arg Glu Asn Pro Leu Thr Val Ser Tyr Lys Arg Ser Val 500 505 510 gcc aag aca ctg ttc att gtg gtc gtt gtc ttt gca gct cta cga ctg 1584 Ala Lys Thr Leu Phe Ile Val Val Val Val Phe Ala Ala Leu Arg Leu 515 520 525 ccc ttt aca atc ctg gtt gta cta cgg gaa aaa tac ttc ggt gaa gat 1632 Pro Phe Thr Ile Leu Val Val Leu Arg Glu Lys Tyr Phe Gly Glu Asp 530 535 540 gtc tct gtc agc agt gga atg cag cta ttc tgg tac ata tca cag tat 1680 Val Ser Val Ser Ser Gly Met Gln Leu Phe Trp Tyr Ile Ser Gln Tyr 545 550 555 560 ttg atg ttt ctg aac gcc gcc gtc aat ccg ctg atc tat ggc ttc aac 1728 Leu Met Phe Leu Asn Ala Ala Val Asn Pro Leu Ile Tyr Gly Phe Asn 565 570 575 aat gag aac ttt aga agg gcc tac tac caa att tct tgg gtt cgc cga 1776 Asn Glu Asn Phe Arg Arg Ala Tyr Tyr Gln Ile Ser Trp Val Arg Arg 580 585 590 tgg cga gac gcc acc caa atg aag aag ttt tct cga tca cca gac cac 1824 Trp Arg Asp Ala Thr Gln Met Lys Lys Phe Ser Arg Ser Pro Asp His 595 600 605 tgc tgc tac tgt gcc ttt atg aag aat gga aaa cga acc tca gag gca 1872 Cys Cys Tyr Cys Ala Phe Met Lys Asn Gly Lys Arg Thr Ser Glu Ala 610 615 620 gca caa aag gca gga aat tta gaa aaa gac ata agc aag gat atg tcg 1920 Ala Gln Lys Ala Gly Asn Leu Glu Lys Asp Ile Ser Lys Asp Met Ser 625 630 635 640 tcg gca caa caa tcg gcc aag tca acg aag ata gtt gaa aat gaa ttt 1968 Ser Ala Gln Gln Ser Ala Lys Ser Thr Lys Ile Val Glu Asn Glu Phe 645 650 655 gta tca gaa atc gag gca gac gga ttt ata taa 2001 Val Ser Glu Ile Glu Ala Asp Gly Phe Ile 660 665 <210> SEQ ID NO 16 <211> LENGTH: 666 <212> TYPE: PRT <213> ORGANISM: Drosophila melanogaster <400> SEQUENCE: 16 Met Ala Asn Leu Arg Pro Leu Ser Ala Glu Leu Arg Arg Ile Ala Glu 1 5 10 15 Thr Glu Leu Asn Glu Val Glu Glu Arg Val Pro Ala Asp Leu Lys Ala 20 25 30 Leu Arg Asp Trp Leu Ala Lys Gln Pro His Leu Arg Ala Arg Gln Asp 35 40 45 Asp Gln Phe Leu Val Gly Phe Leu Arg Gly Cys Lys Phe Ser Leu Glu 50 55 60 Lys Thr Lys Ser Lys Leu Asp His Phe Tyr Thr Ile Lys Thr Leu Met 65 70 75 80 Pro Glu Leu Phe Gly Lys Arg Leu Val Asp Glu Arg Asn Leu Ile Leu 85 90 95 Cys Arg Ser Gly Thr Tyr Val Arg Leu Pro Lys Pro Trp Gly Thr Asp 100 105 110 Gly Pro Arg Leu Gln Leu Thr Asn Tyr Glu Lys Phe Asp Pro Lys Glu 115 120 125 Phe Lys Leu Leu Asp Leu Phe Arg Tyr Gln Thr Met Ile Thr Glu Gln 130 135 140 Ser Ile Arg Glu Asp Asp His Ser Asn Ile Ser Gly Tyr Val Glu Ile 145 150 155 160 Val Asp Met Ala Lys Met Ser Leu Ser Phe Leu Ala Gln Leu Asp Phe 165 170 175 Thr Leu Ile Lys Arg Met Gly Ile Phe Ala Glu Lys Ala Gln Pro Thr 180 185 190 Arg Leu Lys Gly Val His Leu Ile Asn Cys Pro Lys Glu Gly Val Ala 195 200 205 Leu Leu Asn Leu Ala Lys Ser Leu Met Pro Ser Lys Leu Gln Gln Arg 210 215 220 Phe His Val Tyr Lys Asn Leu Glu Gln Leu Asn Glu Val Ile Pro Arg 225 230 235 240 Glu Tyr Leu Pro Glu Glu Tyr Gly Gly Asn Asn Gly Arg Ile Ala Asp 245 250 255 Ile Gln Ala Glu Ala Glu Lys Lys Leu Leu Ser Tyr Glu Ser Tyr Phe 260 265 270 Ala Glu Asp Ser Gln Tyr Gly Phe Asp Phe Gly Lys Trp Asp Phe Pro 275 280 285 Ala Glu Arg Ile Trp Leu His Lys Pro Asn Gly Glu Ile Thr Trp Lys 290 295 300 Ile Cys Thr Phe Leu Pro Leu Ile Ala Phe Gly Leu Tyr Gly Asn Phe 305 310 315 320 Ser Met Val Tyr Val Ile Ala Thr Asn Arg Ser Leu Arg Ser Pro Thr 325 330 335 Asn Leu Ile Ile Ala Asn Met Ala Val Ala Asp Leu Leu Thr Leu Ala 340 345 350 Ile Cys Pro Ala Met Phe Met Val Asn Asp Phe Tyr Gln Asn Tyr Gln 355 360 365 Leu Gly Cys Val Gly Cys Lys Leu Glu Gly Phe Leu Val Val Val Phe 370 375 380 Leu Ile Thr Ala Val Leu Asn Leu Ser Val Val Ser Tyr Asp Arg Leu 385 390 395 400 Thr Ala Ile Val Leu Pro Met Glu Thr Arg Leu Thr Ile Arg Gly Val 405 410 415 Gln Ile Val Val Val Cys Thr Trp Val Ser Gly Ile Leu Leu Ala Ser 420 425 430 Pro Leu Ala Phe Tyr Arg Ser Tyr Arg Val Arg Val Trp Lys Asn Phe 435 440 445 Thr Glu Arg Tyr Cys Lys Glu Asn Thr Ser Val Leu Pro Lys Tyr Trp 450 455 460 Tyr Val Leu Ile Thr Ile Leu Val Trp Leu Pro Leu Gly Ile Met Leu 465 470 475 480 Ile Cys Tyr Ile Ala Ile Phe Tyr Lys Leu Asp Arg Tyr Glu Lys Arg 485 490 495 Val Leu Ser Arg Glu Asn Pro Leu Thr Val Ser Tyr Lys Arg Ser Val 500 505 510 Ala Lys Thr Leu Phe Ile Val Val Val Val Phe Ala Ala Leu Arg Leu 515 520 525 Pro Phe Thr Ile Leu Val Val Leu Arg Glu Lys Tyr Phe Gly Glu Asp 530 535 540 Val Ser Val Ser Ser Gly Met Gln Leu Phe Trp Tyr Ile Ser Gln Tyr 545 550 555 560 Leu Met Phe Leu Asn Ala Ala Val Asn Pro Leu Ile Tyr Gly Phe Asn 565 570 575 Asn Glu Asn Phe Arg Arg Ala Tyr Tyr Gln Ile Ser Trp Val Arg Arg 580 585 590 Trp Arg Asp Ala Thr Gln Met Lys Lys Phe Ser Arg Ser Pro Asp His 595 600 605 Cys Cys Tyr Cys Ala Phe Met Lys Asn Gly Lys Arg Thr Ser Glu Ala 610 615 620 Ala Gln Lys Ala Gly Asn Leu Glu Lys Asp Ile Ser Lys Asp Met Ser 625 630 635 640 Ser Ala Gln Gln Ser Ala Lys Ser Thr Lys Ile Val Glu Asn Glu Phe 645 650 655 Val Ser Glu Ile Glu Ala Asp Gly Phe Ile 660 665 <210> SEQ ID NO 17 <211> LENGTH: 1233 <212> TYPE: DNA <213> ORGANISM: Drosophila melanogaster <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(1230) <400> SEQUENCE: 17 atg gaa acg gac ttg gcc atg aac atc ggc ctg gac act tcc ggt gaa 48 Met Glu Thr Asp Leu Ala Met Asn Ile Gly Leu Asp Thr Ser Gly Glu 1 5 10 15 gcc ccc aca gcc cta ccc ccg atg ccg aat gtc acc gag acg ctg tgg 96 Ala Pro Thr Ala Leu Pro Pro Met Pro Asn Val Thr Glu Thr Leu Trp 20 25 30 gat ctg gcc atg gtg gtc agt cag tcc aca cag tgg ccc ctc ctg gac 144 Asp Leu Ala Met Val Val Ser Gln Ser Thr Gln Trp Pro Leu Leu Asp 35 40 45 acc ggc tcg tcc gag aac ttc agc gaa ctg gtc acc acc gag aca ccc 192 Thr Gly Ser Ser Glu Asn Phe Ser Glu Leu Val Thr Thr Glu Thr Pro 50 55 60 tac gtg ccc tac ggc cgt cga ccg gaa acc tac atc gtg ccc atc ctc 240 Tyr Val Pro Tyr Gly Arg Arg Pro Glu Thr Tyr Ile Val Pro Ile Leu 65 70 75 80 ttt gcc ctg atc ttc gtg gtc ggt gtc ctg ggc aat ggc act ttg att 288 Phe Ala Leu Ile Phe Val Val Gly Val Leu Gly Asn Gly Thr Leu Ile 85 90 95 gtg gtc ttc ctc agt gtg cga cag atg cga aat gtt cca aac acc ggc 336 Val Val Phe Leu Ser Val Arg Gln Met Arg Asn Val Pro Asn Thr Gly 100 105 110 ggc cag aga acg tgg caa aca aag tgc cac atg cag ctt att tat ggt 384 Gly Gln Arg Thr Trp Gln Thr Lys Cys His Met Gln Leu Ile Tyr Gly 115 120 125 aag cgg cgt ggt tgg ata aag tcg gaa tta ctg cat gag atc acg gac 432 Lys Arg Arg Gly Trp Ile Lys Ser Glu Leu Leu His Glu Ile Thr Asp 130 135 140 cga att gga tgt gcc act act gag cac cat tcg ttc gct ggc ctc aag 480 Arg Ile Gly Cys Ala Thr Thr Glu His His Ser Phe Ala Gly Leu Lys 145 150 155 160 ttt tac aca gtt gaa tat tgg cca tat ggc agc ttc ctg tgc agc ctg 528 Phe Tyr Thr Val Glu Tyr Trp Pro Tyr Gly Ser Phe Leu Cys Ser Leu 165 170 175 tcg gag ttc atg aag gat gtg tcc atc gga gtg tca gtg ttt acg ctg 576 Ser Glu Phe Met Lys Asp Val Ser Ile Gly Val Ser Val Phe Thr Leu 180 185 190 act gca tta tcc ggc gat cgg tac ttt gcc atc gtg gat cct ttg agg 624 Thr Ala Leu Ser Gly Asp Arg Tyr Phe Ala Ile Val Asp Pro Leu Arg 195 200 205 aag ttc cac gct cat ggt ggt ggt cgt cgg gcc acc aga atg acc ttg 672 Lys Phe His Ala His Gly Gly Gly Arg Arg Ala Thr Arg Met Thr Leu 210 215 220 gcc acc gcg gtt tcc att tgg ctg ctg gcc ata ctc tgc gga ctt cca 720 Ala Thr Ala Val Ser Ile Trp Leu Leu Ala Ile Leu Cys Gly Leu Pro 225 230 235 240 gcg cta att gga agt aac ctg aag cat ctc ggc ata aac gaa aag tcc 768 Ala Leu Ile Gly Ser Asn Leu Lys His Leu Gly Ile Asn Glu Lys Ser 245 250 255 ata gtc att tgc tat ccg tat ccg gag gag tgg ggc atc aac tac gcc 816 Ile Val Ile Cys Tyr Pro Tyr Pro Glu Glu Trp Gly Ile Asn Tyr Ala 260 265 270 aag tcc atg gtc ctg ttg cac ttc ctg gtc tac tac gcc att cct ttg 864 Lys Ser Met Val Leu Leu His Phe Leu Val Tyr Tyr Ala Ile Pro Leu 275 280 285 gtc gtc ata gca gtt ttc tac gtg ctc atc gcc ctc cat ttg atg tat 912 Val Val Ile Ala Val Phe Tyr Val Leu Ile Ala Leu His Leu Met Tyr 290 295 300 tcg gcc agt gtt cct ggt gaa att cag gga gct gtg cgt cag gtt cgt 960 Ser Ala Ser Val Pro Gly Glu Ile Gln Gly Ala Val Arg Gln Val Arg 305 310 315 320 gcc cgt cgc aaa gtg gct gtt act gtg ctg gcc ttc gtt gtc atc ttt 1008 Ala Arg Arg Lys Val Ala Val Thr Val Leu Ala Phe Val Val Ile Phe 325 330 335 gga att tgc ttt ctg ccc tac cac gtc ttc ttc ctc tgg ttc tac ttc 1056 Gly Ile Cys Phe Leu Pro Tyr His Val Phe Phe Leu Trp Phe Tyr Phe 340 345 350 tgg ccc acc gcc cag gat gat tac aat gcc ttc tgg cat gtg ctg cgc 1104 Trp Pro Thr Ala Gln Asp Asp Tyr Asn Ala Phe Trp His Val Leu Arg 355 360 365 atc gtc gcc tac tgc atg tcc ttt gcc aac agc tgt gcg aat cct gtg 1152 Ile Val Ala Tyr Cys Met Ser Phe Ala Asn Ser Cys Ala Asn Pro Val 370 375 380 gcc cta tac ttc gtg agc ggc gcc ttt cgc aag cat ttc aat agg tat 1200 Ala Leu Tyr Phe Val Ser Gly Ala Phe Arg Lys His Phe Asn Arg Tyr 385 390 395 400 ttg ttc gtt tac atc aat cca cca gcc gca taa 1233 Leu Phe Val Tyr Ile Asn Pro Pro Ala Ala 405 410 <210> SEQ ID NO 18 <211> LENGTH: 410 <212> TYPE: PRT <213> ORGANISM: Drosophila melanogaster <400> SEQUENCE: 18 Met Glu Thr Asp Leu Ala Met Asn Ile Gly Leu Asp Thr Ser Gly Glu 1 5 10 15 Ala Pro Thr Ala Leu Pro Pro Met Pro Asn Val Thr Glu Thr Leu Trp 20 25 30 Asp Leu Ala Met Val Val Ser Gln Ser Thr Gln Trp Pro Leu Leu Asp 35 40 45 Thr Gly Ser Ser Glu Asn Phe Ser Glu Leu Val Thr Thr Glu Thr Pro 50 55 60 Tyr Val Pro Tyr Gly Arg Arg Pro Glu Thr Tyr Ile Val Pro Ile Leu 65 70 75 80 Phe Ala Leu Ile Phe Val Val Gly Val Leu Gly Asn Gly Thr Leu Ile 85 90 95 Val Val Phe Leu Ser Val Arg Gln Met Arg Asn Val Pro Asn Thr Gly 100 105 110 Gly Gln Arg Thr Trp Gln Thr Lys Cys His Met Gln Leu Ile Tyr Gly 115 120 125 Lys Arg Arg Gly Trp Ile Lys Ser Glu Leu Leu His Glu Ile Thr Asp 130 135 140 Arg Ile Gly Cys Ala Thr Thr Glu His His Ser Phe Ala Gly Leu Lys 145 150 155 160 Phe Tyr Thr Val Glu Tyr Trp Pro Tyr Gly Ser Phe Leu Cys Ser Leu 165 170 175 Ser Glu Phe Met Lys Asp Val Ser Ile Gly Val Ser Val Phe Thr Leu 180 185 190 Thr Ala Leu Ser Gly Asp Arg Tyr Phe Ala Ile Val Asp Pro Leu Arg 195 200 205 Lys Phe His Ala His Gly Gly Gly Arg Arg Ala Thr Arg Met Thr Leu 210 215 220 Ala Thr Ala Val Ser Ile Trp Leu Leu Ala Ile Leu Cys Gly Leu Pro 225 230 235 240 Ala Leu Ile Gly Ser Asn Leu Lys His Leu Gly Ile Asn Glu Lys Ser 245 250 255 Ile Val Ile Cys Tyr Pro Tyr Pro Glu Glu Trp Gly Ile Asn Tyr Ala 260 265 270 Lys Ser Met Val Leu Leu His Phe Leu Val Tyr Tyr Ala Ile Pro Leu 275 280 285 Val Val Ile Ala Val Phe Tyr Val Leu Ile Ala Leu His Leu Met Tyr 290 295 300 Ser Ala Ser Val Pro Gly Glu Ile Gln Gly Ala Val Arg Gln Val Arg 305 310 315 320 Ala Arg Arg Lys Val Ala Val Thr Val Leu Ala Phe Val Val Ile Phe 325 330 335 Gly Ile Cys Phe Leu Pro Tyr His Val Phe Phe Leu Trp Phe Tyr Phe 340 345 350 Trp Pro Thr Ala Gln Asp Asp Tyr Asn Ala Phe Trp His Val Leu Arg 355 360 365 Ile Val Ala Tyr Cys Met Ser Phe Ala Asn Ser Cys Ala Asn Pro Val 370 375 380 Ala Leu Tyr Phe Val Ser Gly Ala Phe Arg Lys His Phe Asn Arg Tyr 385 390 395 400 Leu Phe Val Tyr Ile Asn Pro Pro Ala Ala 405 410 <210> SEQ ID NO 19 <211> LENGTH: 2586 <212> TYPE: DNA <213> ORGANISM: Drosophila melanogaster <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(2583) <400> SEQUENCE: 19 atg gag ctg gac gat aat tta ata agc agc ctg ccc gag gga ctc agc 48 Met Glu Leu Asp Asp Asn Leu Ile Ser Ser Leu Pro Glu Gly Leu Ser 1 5 10 15 aaa ttg tcg caa ctg cag gag ctt tcc atc acc agc aat cga ctg cgc 96 Lys Leu Ser Gln Leu Gln Glu Leu Ser Ile Thr Ser Asn Arg Leu Arg 20 25 30 tgg ata aac gac acg gaa ctg ccc agg agc atg caa atg ctg gac atg 144 Trp Ile Asn Asp Thr Glu Leu Pro Arg Ser Met Gln Met Leu Asp Met 35 40 45 agg gcc aat cca ctg tcc aca att tcg cca ggg gcg ttt cgg ggc atg 192 Arg Ala Asn Pro Leu Ser Thr Ile Ser Pro Gly Ala Phe Arg Gly Met 50 55 60 tcc aag ttg cgg aag ctg att tta tcg gat gtg cga act ttg cgc tcg 240 Ser Lys Leu Arg Lys Leu Ile Leu Ser Asp Val Arg Thr Leu Arg Ser 65 70 75 80 ttt ccc gaa ctt gag gcc tgc cat gcg ctg gaa ata ctg aaa ctg gat 288 Phe Pro Glu Leu Glu Ala Cys His Ala Leu Glu Ile Leu Lys Leu Asp 85 90 95 cgt gcc ggc att cag gag gtg cca gcg aat cta tgc cgc caa acg cca 336 Arg Ala Gly Ile Gln Glu Val Pro Ala Asn Leu Cys Arg Gln Thr Pro 100 105 110 aga ctg aag agt tta gat cta tcg agc aat caa att gaa aag att cag 384 Arg Leu Lys Ser Leu Asp Leu Ser Ser Asn Gln Ile Glu Lys Ile Gln 115 120 125 gga aag ccc ttc aat gga ttg aag caa ttg aac gat ctg ttg ctc tcc 432 Gly Lys Pro Phe Asn Gly Leu Lys Gln Leu Asn Asp Leu Leu Leu Ser 130 135 140 tac aat cga atc aag gca ctg cca caa gat gcc ttt cag ggc att ccg 480 Tyr Asn Arg Ile Lys Ala Leu Pro Gln Asp Ala Phe Gln Gly Ile Pro 145 150 155 160 aag ctc caa ctt ctc aag cag ttg ggt gct tcc atg cat gat cct tgg 528 Lys Leu Gln Leu Leu Lys Gln Leu Gly Ala Ser Met His Asp Pro Trp 165 170 175 gag acg gct att aac ttc aac gaa gag cag ctg caa aca caa acg gga 576 Glu Thr Ala Ile Asn Phe Asn Glu Glu Gln Leu Gln Thr Gln Thr Gly 180 185 190 ggc caa atc gcc acc agc tac atg gag gag tac ttc gag gag cac gat 624 Gly Gln Ile Ala Thr Ser Tyr Met Glu Glu Tyr Phe Glu Glu His Asp 195 200 205 gtg agt ggt cct gcc acg gga tac ggc ttt ggt act gga cta ttc tct 672 Val Ser Gly Pro Ala Thr Gly Tyr Gly Phe Gly Thr Gly Leu Phe Ser 210 215 220 ggt atg tcc aca gag gac ttt caa ccg ggt tcg gtg cag tgc ctg cca 720 Gly Met Ser Thr Glu Asp Phe Gln Pro Gly Ser Val Gln Cys Leu Pro 225 230 235 240 atg cca gga cct ttt cta ccc tgc gcc gat ctc ttc gat tgg tgg act 768 Met Pro Gly Pro Phe Leu Pro Cys Ala Asp Leu Phe Asp Trp Trp Thr 245 250 255 ctg cgc tgc gga gtg tgg gtg gtt ttt ctg ttg tct ctc ctg ggc aac 816 Leu Arg Cys Gly Val Trp Val Val Phe Leu Leu Ser Leu Leu Gly Asn 260 265 270 gga acg gtg gtg ttt gtg ctg ctc tgc tcg cga tca aag atg gat gtg 864 Gly Thr Val Val Phe Val Leu Leu Cys Ser Arg Ser Lys Met Asp Val 275 280 285 ccc cga ttt cta gtc tgt aat ctg gcc gcg gcc gac ttc ttc atg ggc 912 Pro Arg Phe Leu Val Cys Asn Leu Ala Ala Ala Asp Phe Phe Met Gly 290 295 300 atc tac ctg ggt att ctg gcc att gtg gat gcg gcg acg ttg ggc gaa 960 Ile Tyr Leu Gly Ile Leu Ala Ile Val Asp Ala Ala Thr Leu Gly Glu 305 310 315 320 ttt cgc atg ttt gcc att cct tgg cag atg tcc gtg ctc tgc cag ttg 1008 Phe Arg Met Phe Ala Ile Pro Trp Gln Met Ser Val Leu Cys Gln Leu 325 330 335 tcc ggt ttt ctg gcc gta ctc agc tca gaa tta tcc gtt tac acg ttg 1056 Ser Gly Phe Leu Ala Val Leu Ser Ser Glu Leu Ser Val Tyr Thr Leu 340 345 350 gct gtg atc act ttg gag cgc aat tac gcc atc act cat gcc att cac 1104 Ala Val Ile Thr Leu Glu Arg Asn Tyr Ala Ile Thr His Ala Ile His 355 360 365 ctg aac aag agg ctc tcc ttg aag cag gcg gga tat ata atg agt gta 1152 Leu Asn Lys Arg Leu Ser Leu Lys Gln Ala Gly Tyr Ile Met Ser Val 370 375 380 gga tgg gtt ttt gcc ctg atc atg gct ttg atg cct ttg gtt ggt gtt 1200 Gly Trp Val Phe Ala Leu Ile Met Ala Leu Met Pro Leu Val Gly Val 385 390 395 400 tcg gac tac agg aag ttt gcc gtg tgt ttg cca ttc gag acc acc act 1248 Ser Asp Tyr Arg Lys Phe Ala Val Cys Leu Pro Phe Glu Thr Thr Thr 405 410 415 gga ccg gcc agt ttg acc tat gta atc tca ctg atg ttc atc aac gga 1296 Gly Pro Ala Ser Leu Thr Tyr Val Ile Ser Leu Met Phe Ile Asn Gly 420 425 430 tgc gca ttt ctc act ctg atg ggt tgc tac ctg aag atg tac tgg gcc 1344 Cys Ala Phe Leu Thr Leu Met Gly Cys Tyr Leu Lys Met Tyr Trp Ala 435 440 445 ata agg ggc agc cag gca tgg aac acg aat gat tcg cga att gcc aag 1392 Ile Arg Gly Ser Gln Ala Trp Asn Thr Asn Asp Ser Arg Ile Ala Lys 450 455 460 cga atg gct ctg ttg gtc ttt act gac ttc ctc tgc tgg tca cct atc 1440 Arg Met Ala Leu Leu Val Phe Thr Asp Phe Leu Cys Trp Ser Pro Ile 465 470 475 480 gcc ttc ttc tcg atc act gcc atc ttt ggc ctg caa ctg att tcg ctg 1488 Ala Phe Phe Ser Ile Thr Ala Ile Phe Gly Leu Gln Leu Ile Ser Leu 485 490 495 gag cag gcc aag atc ttt acg gta ttt gtg ctg ccc ttg aat agt tgc 1536 Glu Gln Ala Lys Ile Phe Thr Val Phe Val Leu Pro Leu Asn Ser Cys 500 505 510 tgc aat ccc ttt ctc tac gcc ata atg acc aag cag ttc aag aag gac 1584 Cys Asn Pro Phe Leu Tyr Ala Ile Met Thr Lys Gln Phe Lys Lys Asp 515 520 525 tgt gtg acg ttg tgc aaa cat ttc gaa gaa tcc cgc gtc gtg gga ggc 1632 Cys Val Thr Leu Cys Lys His Phe Glu Glu Ser Arg Val Val Gly Gly 530 535 540 ggt ggt ccg ggt gga cgt ggt gca gtg gca aga acc aag agg ggt gat 1680 Gly Gly Pro Gly Gly Arg Gly Ala Val Ala Arg Thr Lys Arg Gly Asp 545 550 555 560 ctc ccg cca cca ctc tta cca gct gca gcg gtg gca cat ccg cca ggc 1728 Leu Pro Pro Pro Leu Leu Pro Ala Ala Ala Val Ala His Pro Pro Gly 565 570 575 tgt cga tgt cta cgg atg ctg ccc agc gaa atg ccc aac tgg cat aaa 1776 Cys Arg Cys Leu Arg Met Leu Pro Ser Glu Met Pro Asn Trp His Lys 580 585 590 atg gag cag aca ccg agc atg tgg cag aga ttg aga aca ttc tgc tgc 1824 Met Glu Gln Thr Pro Ser Met Trp Gln Arg Leu Arg Thr Phe Cys Cys 595 600 605 ggg gag aac cga agg cgt cgc aaa cag cga cgg caa ccg caa cag cga 1872 Gly Glu Asn Arg Arg Arg Arg Lys Gln Arg Arg Gln Pro Gln Gln Arg 610 615 620 cgc cag aga gcc tat act gcc gca gcc gcc aat ccg tat cag tat cag 1920 Arg Gln Arg Ala Tyr Thr Ala Ala Ala Ala Asn Pro Tyr Gln Tyr Gln 625 630 635 640 ttt gct gaa ctg cgt cag caa cgc cag aat cga gcc agt tcc att tcc 1968 Phe Ala Glu Leu Arg Gln Gln Arg Gln Asn Arg Ala Ser Ser Ile Ser 645 650 655 agc gag aat ttc tgc agc tca aga tca tcc agc tgg cga cat ggt cca 2016 Ser Glu Asn Phe Cys Ser Ser Arg Ser Ser Ser Trp Arg His Gly Pro 660 665 670 cca tcc tca gca ccc gtg cca ccg ggt aac tgc agc atg ccg ctg aag 2064 Pro Ser Ser Ala Pro Val Pro Pro Gly Asn Cys Ser Met Pro Leu Lys 675 680 685 atg ctg gag cca cat gct cat ccg cac ggt cat ggg cgc aga cga cac 2112 Met Leu Glu Pro His Ala His Pro His Gly His Gly Arg Arg Arg His 690 695 700 tcc gcc tgg ctg atc acg cgg aaa acg tcg cag gac tcg aac ttg tcc 2160 Ser Ala Trp Leu Ile Thr Arg Lys Thr Ser Gln Asp Ser Asn Leu Ser 705 710 715 720 agc tcg cgc aat gac tcc tcc gcc tcg gcc acc acc gcc agc acc tcc 2208 Ser Ser Arg Asn Asp Ser Ser Ala Ser Ala Thr Thr Ala Ser Thr Ser 725 730 735 acg ttc cgg tta tcc cgg tca agt gcc ggc agc agc aca ccc ctg ccc 2256 Thr Phe Arg Leu Ser Arg Ser Ser Ala Gly Ser Ser Thr Pro Leu Pro 740 745 750 tcg atc ata gcc cac aac ggg aag gcc cag ttg gat gca gtt aaa cca 2304 Ser Ile Ile Ala His Asn Gly Lys Ala Gln Leu Asp Ala Val Lys Pro 755 760 765 cga ttg gtc cgc cag gaa gca gtc cag gag gaa gag gac tca tca cca 2352 Arg Leu Val Arg Gln Glu Ala Val Gln Glu Glu Glu Asp Ser Ser Pro 770 775 780 cct cgc ctg gga gta cgc ttc cta ccc acc ata ccc tcg gct gcc gac 2400 Pro Arg Leu Gly Val Arg Phe Leu Pro Thr Ile Pro Ser Ala Ala Asp 785 790 795 800 agt tct gtc gtc atg gaa gat ggc gac tcg gcc aac acg gga gta gcc 2448 Ser Ser Val Val Met Glu Asp Gly Asp Ser Ala Asn Thr Gly Val Ala 805 810 815 agt ttt cta ggc atg cca ctt cct ggg gcg tcc agt ggc ttc ctt ata 2496 Ser Phe Leu Gly Met Pro Leu Pro Gly Ala Ser Ser Gly Phe Leu Ile 820 825 830 gct cca acc acc gct gcc acc acc tcc cca ccc ccg gtg gtc ctg cag 2544 Ala Pro Thr Thr Ala Ala Thr Thr Ser Pro Pro Pro Val Val Leu Gln 835 840 845 ccg gca aag cct cct ccc gat ccc aac gat gca cca cta tga 2586 Pro Ala Lys Pro Pro Pro Asp Pro Asn Asp Ala Pro Leu 850 855 860 <210> SEQ ID NO 20 <211> LENGTH: 861 <212> TYPE: PRT <213> ORGANISM: Drosophila melanogaster <400> SEQUENCE: 20 Met Glu Leu Asp Asp Asn Leu Ile Ser Ser Leu Pro Glu Gly Leu Ser 1 5 10 15 Lys Leu Ser Gln Leu Gln Glu Leu Ser Ile Thr Ser Asn Arg Leu Arg 20 25 30 Trp Ile Asn Asp Thr Glu Leu Pro Arg Ser Met Gln Met Leu Asp Met 35 40 45 Arg Ala Asn Pro Leu Ser Thr Ile Ser Pro Gly Ala Phe Arg Gly Met 50 55 60 Ser Lys Leu Arg Lys Leu Ile Leu Ser Asp Val Arg Thr Leu Arg Ser 65 70 75 80 Phe Pro Glu Leu Glu Ala Cys His Ala Leu Glu Ile Leu Lys Leu Asp 85 90 95 Arg Ala Gly Ile Gln Glu Val Pro Ala Asn Leu Cys Arg Gln Thr Pro 100 105 110 Arg Leu Lys Ser Leu Asp Leu Ser Ser Asn Gln Ile Glu Lys Ile Gln 115 120 125 Gly Lys Pro Phe Asn Gly Leu Lys Gln Leu Asn Asp Leu Leu Leu Ser 130 135 140 Tyr Asn Arg Ile Lys Ala Leu Pro Gln Asp Ala Phe Gln Gly Ile Pro 145 150 155 160 Lys Leu Gln Leu Leu Lys Gln Leu Gly Ala Ser Met His Asp Pro Trp 165 170 175 Glu Thr Ala Ile Asn Phe Asn Glu Glu Gln Leu Gln Thr Gln Thr Gly 180 185 190 Gly Gln Ile Ala Thr Ser Tyr Met Glu Glu Tyr Phe Glu Glu His Asp 195 200 205 Val Ser Gly Pro Ala Thr Gly Tyr Gly Phe Gly Thr Gly Leu Phe Ser 210 215 220 Gly Met Ser Thr Glu Asp Phe Gln Pro Gly Ser Val Gln Cys Leu Pro 225 230 235 240 Met Pro Gly Pro Phe Leu Pro Cys Ala Asp Leu Phe Asp Trp Trp Thr 245 250 255 Leu Arg Cys Gly Val Trp Val Val Phe Leu Leu Ser Leu Leu Gly Asn 260 265 270 Gly Thr Val Val Phe Val Leu Leu Cys Ser Arg Ser Lys Met Asp Val 275 280 285 Pro Arg Phe Leu Val Cys Asn Leu Ala Ala Ala Asp Phe Phe Met Gly 290 295 300 Ile Tyr Leu Gly Ile Leu Ala Ile Val Asp Ala Ala Thr Leu Gly Glu 305 310 315 320 Phe Arg Met Phe Ala Ile Pro Trp Gln Met Ser Val Leu Cys Gln Leu 325 330 335 Ser Gly Phe Leu Ala Val Leu Ser Ser Glu Leu Ser Val Tyr Thr Leu 340 345 350 Ala Val Ile Thr Leu Glu Arg Asn Tyr Ala Ile Thr His Ala Ile His 355 360 365 Leu Asn Lys Arg Leu Ser Leu Lys Gln Ala Gly Tyr Ile Met Ser Val 370 375 380 Gly Trp Val Phe Ala Leu Ile Met Ala Leu Met Pro Leu Val Gly Val 385 390 395 400 Ser Asp Tyr Arg Lys Phe Ala Val Cys Leu Pro Phe Glu Thr Thr Thr 405 410 415 Gly Pro Ala Ser Leu Thr Tyr Val Ile Ser Leu Met Phe Ile Asn Gly 420 425 430 Cys Ala Phe Leu Thr Leu Met Gly Cys Tyr Leu Lys Met Tyr Trp Ala 435 440 445 Ile Arg Gly Ser Gln Ala Trp Asn Thr Asn Asp Ser Arg Ile Ala Lys 450 455 460 Arg Met Ala Leu Leu Val Phe Thr Asp Phe Leu Cys Trp Ser Pro Ile 465 470 475 480 Ala Phe Phe Ser Ile Thr Ala Ile Phe Gly Leu Gln Leu Ile Ser Leu 485 490 495 Glu Gln Ala Lys Ile Phe Thr Val Phe Val Leu Pro Leu Asn Ser Cys 500 505 510 Cys Asn Pro Phe Leu Tyr Ala Ile Met Thr Lys Gln Phe Lys Lys Asp 515 520 525 Cys Val Thr Leu Cys Lys His Phe Glu Glu Ser Arg Val Val Gly Gly 530 535 540 Gly Gly Pro Gly Gly Arg Gly Ala Val Ala Arg Thr Lys Arg Gly Asp 545 550 555 560 Leu Pro Pro Pro Leu Leu Pro Ala Ala Ala Val Ala His Pro Pro Gly 565 570 575 Cys Arg Cys Leu Arg Met Leu Pro Ser Glu Met Pro Asn Trp His Lys 580 585 590 Met Glu Gln Thr Pro Ser Met Trp Gln Arg Leu Arg Thr Phe Cys Cys 595 600 605 Gly Glu Asn Arg Arg Arg Arg Lys Gln Arg Arg Gln Pro Gln Gln Arg 610 615 620 Arg Gln Arg Ala Tyr Thr Ala Ala Ala Ala Asn Pro Tyr Gln Tyr Gln 625 630 635 640 Phe Ala Glu Leu Arg Gln Gln Arg Gln Asn Arg Ala Ser Ser Ile Ser 645 650 655 Ser Glu Asn Phe Cys Ser Ser Arg Ser Ser Ser Trp Arg His Gly Pro 660 665 670 Pro Ser Ser Ala Pro Val Pro Pro Gly Asn Cys Ser Met Pro Leu Lys 675 680 685 Met Leu Glu Pro His Ala His Pro His Gly His Gly Arg Arg Arg His 690 695 700 Ser Ala Trp Leu Ile Thr Arg Lys Thr Ser Gln Asp Ser Asn Leu Ser 705 710 715 720 Ser Ser Arg Asn Asp Ser Ser Ala Ser Ala Thr Thr Ala Ser Thr Ser 725 730 735 Thr Phe Arg Leu Ser Arg Ser Ser Ala Gly Ser Ser Thr Pro Leu Pro 740 745 750 Ser Ile Ile Ala His Asn Gly Lys Ala Gln Leu Asp Ala Val Lys Pro 755 760 765 Arg Leu Val Arg Gln Glu Ala Val Gln Glu Glu Glu Asp Ser Ser Pro 770 775 780 Pro Arg Leu Gly Val Arg Phe Leu Pro Thr Ile Pro Ser Ala Ala Asp 785 790 795 800 Ser Ser Val Val Met Glu Asp Gly Asp Ser Ala Asn Thr Gly Val Ala 805 810 815 Ser Phe Leu Gly Met Pro Leu Pro Gly Ala Ser Ser Gly Phe Leu Ile 820 825 830 Ala Pro Thr Thr Ala Ala Thr Thr Ser Pro Pro Pro Val Val Leu Gln 835 840 845 Pro Ala Lys Pro Pro Pro Asp Pro Asn Asp Ala Pro Leu 850 855 860 <210> SEQ ID NO 21 <211> LENGTH: 606 <212> TYPE: DNA <213> ORGANISM: Drosophila melanogaster <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(603) <400> SEQUENCE: 21 atg ttc aac tac gag gag ggg gat gcc gac cag gcg gcc atg gct gca 48 Met Phe Asn Tyr Glu Glu Gly Asp Ala Asp Gln Ala Ala Met Ala Ala 1 5 10 15 gcg gct gcc tat agg gca ctg ctc gac tac tat gcc aat gcg cca agt 96 Ala Ala Ala Tyr Arg Ala Leu Leu Asp Tyr Tyr Ala Asn Ala Pro Ser 20 25 30 gcg gcg ggt cac ata gtg tcg ctc aac gtg gca ccc tac aat gga act 144 Ala Ala Gly His Ile Val Ser Leu Asn Val Ala Pro Tyr Asn Gly Thr 35 40 45 gga aac gga ggc act gtc tcc ttg gcg ggc aat gcg aca agc agc tat 192 Gly Asn Gly Gly Thr Val Ser Leu Ala Gly Asn Ala Thr Ser Ser Tyr 50 55 60 ggc gat gat gat agg gat ggc tat atg gac acc gag ccc agt gac ctg 240 Gly Asp Asp Asp Arg Asp Gly Tyr Met Asp Thr Glu Pro Ser Asp Leu 65 70 75 80 gtc acc gaa ctg gcc ttc tcc ctg ggc acc agt tca agt cca agt ccc 288 Val Thr Glu Leu Ala Phe Ser Leu Gly Thr Ser Ser Ser Pro Ser Pro 85 90 95 agt tcc aca ccc gct tcc agc tcc agt act tcc act ggc atg ccc gtc 336 Ser Ser Thr Pro Ala Ser Ser Ser Ser Thr Ser Thr Gly Met Pro Val 100 105 110 tgg ctg ata ccc agc tat agc atg att ctg ctg ttc gcc gtg ctg ggc 384 Trp Leu Ile Pro Ser Tyr Ser Met Ile Leu Leu Phe Ala Val Leu Gly 115 120 125 aac ctg ctg gtc atc tcg acg ctg gtg cag aat cgc cgg atg cgt acc 432 Asn Leu Leu Val Ile Ser Thr Leu Val Gln Asn Arg Arg Met Arg Thr 130 135 140 ata acc aac gtg ttc ctg ctc aac ctg gcc ata tcg gac atg ctg ctg 480 Ile Thr Asn Val Phe Leu Leu Asn Leu Ala Ile Ser Asp Met Leu Leu 145 150 155 160 ggc gtg ctc tgc atg ccc gtc acc ctg gtg ggc acc ctg ctg cga aac 528 Gly Val Leu Cys Met Pro Val Thr Leu Val Gly Thr Leu Leu Arg Asn 165 170 175 ttc atc ttt ggc gag ttc ctc tgc aag ctc ttt cag ttc tcg caa ggt 576 Phe Ile Phe Gly Glu Phe Leu Cys Lys Leu Phe Gln Phe Ser Gln Gly 180 185 190 tct tgg gct ctt ggg ttc ctg cgc att tag 606 Ser Trp Ala Leu Gly Phe Leu Arg Ile 195 200 <210> SEQ ID NO 22 <211> LENGTH: 201 <212> TYPE: PRT <213> ORGANISM: Drosophila melanogaster <400> SEQUENCE: 22 Met Phe Asn Tyr Glu Glu Gly Asp Ala Asp Gln Ala Ala Met Ala Ala 1 5 10 15 Ala Ala Ala Tyr Arg Ala Leu Leu Asp Tyr Tyr Ala Asn Ala Pro Ser 20 25 30 Ala Ala Gly His Ile Val Ser Leu Asn Val Ala Pro Tyr Asn Gly Thr 35 40 45 Gly Asn Gly Gly Thr Val Ser Leu Ala Gly Asn Ala Thr Ser Ser Tyr 50 55 60 Gly Asp Asp Asp Arg Asp Gly Tyr Met Asp Thr Glu Pro Ser Asp Leu 65 70 75 80 Val Thr Glu Leu Ala Phe Ser Leu Gly Thr Ser Ser Ser Pro Ser Pro 85 90 95 Ser Ser Thr Pro Ala Ser Ser Ser Ser Thr Ser Thr Gly Met Pro Val 100 105 110 Trp Leu Ile Pro Ser Tyr Ser Met Ile Leu Leu Phe Ala Val Leu Gly 115 120 125 Asn Leu Leu Val Ile Ser Thr Leu Val Gln Asn Arg Arg Met Arg Thr 130 135 140 Ile Thr Asn Val Phe Leu Leu Asn Leu Ala Ile Ser Asp Met Leu Leu 145 150 155 160 Gly Val Leu Cys Met Pro Val Thr Leu Val Gly Thr Leu Leu Arg Asn 165 170 175 Phe Ile Phe Gly Glu Phe Leu Cys Lys Leu Phe Gln Phe Ser Gln Gly 180 185 190 Ser Trp Ala Leu Gly Phe Leu Arg Ile 195 200 <210> SEQ ID NO 23 <211> LENGTH: 1224 <212> TYPE: DNA <213> ORGANISM: Drosophila melanogaster <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(1221) <400> SEQUENCE: 23 atg gcc tcc gtg gcc gtt tcg tcc tgg acc ttg gtg gcc ata tcc tgt 48 Met Ala Ser Val Ala Val Ser Ser Trp Thr Leu Val Ala Ile Ser Cys 1 5 10 15 gag cgc tac tac gcg ata tgc cat cca ctg cgc tcg cga tcc tgg cag 96 Glu Arg Tyr Tyr Ala Ile Cys His Pro Leu Arg Ser Arg Ser Trp Gln 20 25 30 aca atc agt cac gcc tac aag atc atc ggc ttc atc tgg ctg ggc ggc 144 Thr Ile Ser His Ala Tyr Lys Ile Ile Gly Phe Ile Trp Leu Gly Gly 35 40 45 atc ctc tgc atg acg ccc ata gcg gtc ttt agt caa ttg ata ccc acc 192 Ile Leu Cys Met Thr Pro Ile Ala Val Phe Ser Gln Leu Ile Pro Thr 50 55 60 agt cga ccg ggc tac tgc aag tgc cgt gag ttt tgg ccc gac cag gga 240 Ser Arg Pro Gly Tyr Cys Lys Cys Arg Glu Phe Trp Pro Asp Gln Gly 65 70 75 80 tac gag ctc ttc tac aac atc ctg ctg gac ttc ctg ctg ctc gtc ctg 288 Tyr Glu Leu Phe Tyr Asn Ile Leu Leu Asp Phe Leu Leu Leu Val Leu 85 90 95 ccg ctt ctc gtc ctc tgc gtg gcc tac atc ctc atc acg cgt acc ctg 336 Pro Leu Leu Val Leu Cys Val Ala Tyr Ile Leu Ile Thr Arg Thr Leu 100 105 110 tac gta ggc atg gcc aag gac agc gga cgc atc ctg cag caa tcg ctg 384 Tyr Val Gly Met Ala Lys Asp Ser Gly Arg Ile Leu Gln Gln Ser Leu 115 120 125 cct gtt tcc gct aca acg gcc ggc gga agc gca ccg aat ccg ggc acc 432 Pro Val Ser Ala Thr Thr Ala Gly Gly Ser Ala Pro Asn Pro Gly Thr 130 135 140 agc agc agt agt aac tgc atc ctg gtc ctg acc gcc acc gca gtc tat 480 Ser Ser Ser Ser Asn Cys Ile Leu Val Leu Thr Ala Thr Ala Val Tyr 145 150 155 160 aat ggt tgg cgg agg atc aac caa tat ggc aac gac cac ctt gac aac 528 Asn Gly Trp Arg Arg Ile Asn Gln Tyr Gly Asn Asp His Leu Asp Asn 165 170 175 gag acc aac ggc tcc aac tgt gat cac cac cac cac gac gac cac ggt 576 Glu Thr Asn Gly Ser Asn Cys Asp His His His His Asp Asp His Gly 180 185 190 gac gct ggc caa gac ctc ctc gcc cag cat tcg cgt cca cga tgc ggc 624 Asp Ala Gly Gln Asp Leu Leu Ala Gln His Ser Arg Pro Arg Cys Gly 195 200 205 act tcg cag gta gga ttc gtg tcc gat aac cgg tct gcc aat cct att 672 Thr Ser Gln Val Gly Phe Val Ser Asp Asn Arg Ser Ala Asn Pro Ile 210 215 220 ccc tat tcc cat ttc tcc aca atc cac aat cca cta tcc agg tcc aac 720 Pro Tyr Ser His Phe Ser Thr Ile His Asn Pro Leu Ser Arg Ser Asn 225 230 235 240 gag gcc aag acc ctg gag agc aag aag cgt gtg gtc aag atg ctg ttc 768 Glu Ala Lys Thr Leu Glu Ser Lys Lys Arg Val Val Lys Met Leu Phe 245 250 255 gtc ctg gtg ctg gag ttt ttc atc tgc tgg act ccg ctg tac gtg atc 816 Val Leu Val Leu Glu Phe Phe Ile Cys Trp Thr Pro Leu Tyr Val Ile 260 265 270 aac acg atg gtc atg ctg atc gga ccg gtg gtg tac gag tat gtc gac 864 Asn Thr Met Val Met Leu Ile Gly Pro Val Val Tyr Glu Tyr Val Asp 275 280 285 tac acg gcc atc agt ttc ctc cag ctg ctg gcc tac tca tcc agc tgc 912 Tyr Thr Ala Ile Ser Phe Leu Gln Leu Leu Ala Tyr Ser Ser Ser Cys 290 295 300 tgc aat ccg atc acc tac tgc ttc atg aac gcc agc ttc cgg cgc gcc 960 Cys Asn Pro Ile Thr Tyr Cys Phe Met Asn Ala Ser Phe Arg Arg Ala 305 310 315 320 ttt gtc gac acc ttc aag ggt ctg ccc tgg cgt cgt gga gca ggt gcc 1008 Phe Val Asp Thr Phe Lys Gly Leu Pro Trp Arg Arg Gly Ala Gly Ala 325 330 335 agc gga ggc gtc ggt ggt gct gct ggt gga gga ctc tcc gcc agc cag 1056 Ser Gly Gly Val Gly Gly Ala Ala Gly Gly Gly Leu Ser Ala Ser Gln 340 345 350 gcg ggc gca ggc ccg ggc gcc tat gcg agt gcc aac acc aac att agt 1104 Ala Gly Ala Gly Pro Gly Ala Tyr Ala Ser Ala Asn Thr Asn Ile Ser 355 360 365 ctc aat ccc ggc cta gcc atg ggt atg ggc acc tgg cgg agt cgc tca 1152 Leu Asn Pro Gly Leu Ala Met Gly Met Gly Thr Trp Arg Ser Arg Ser 370 375 380 cgc cac gag ttt ctc aat gcg gtg gtg acc acc aat agt gcc gcc gcc 1200 Arg His Glu Phe Leu Asn Ala Val Val Thr Thr Asn Ser Ala Ala Ala 385 390 395 400 gcc gtc aac agt cct cag ctc taa 1224 Ala Val Asn Ser Pro Gln Leu 405 <210> SEQ ID NO 24 <211> LENGTH: 407 <212> TYPE: PRT <213> ORGANISM: Drosophila melanogaster <400> SEQUENCE: 24 Met Ala Ser Val Ala Val Ser Ser Trp Thr Leu Val Ala Ile Ser Cys 1 5 10 15 Glu Arg Tyr Tyr Ala Ile Cys His Pro Leu Arg Ser Arg Ser Trp Gln 20 25 30 Thr Ile Ser His Ala Tyr Lys Ile Ile Gly Phe Ile Trp Leu Gly Gly 35 40 45 Ile Leu Cys Met Thr Pro Ile Ala Val Phe Ser Gln Leu Ile Pro Thr 50 55 60 Ser Arg Pro Gly Tyr Cys Lys Cys Arg Glu Phe Trp Pro Asp Gln Gly 65 70 75 80 Tyr Glu Leu Phe Tyr Asn Ile Leu Leu Asp Phe Leu Leu Leu Val Leu 85 90 95 Pro Leu Leu Val Leu Cys Val Ala Tyr Ile Leu Ile Thr Arg Thr Leu 100 105 110 Tyr Val Gly Met Ala Lys Asp Ser Gly Arg Ile Leu Gln Gln Ser Leu 115 120 125 Pro Val Ser Ala Thr Thr Ala Gly Gly Ser Ala Pro Asn Pro Gly Thr 130 135 140 Ser Ser Ser Ser Asn Cys Ile Leu Val Leu Thr Ala Thr Ala Val Tyr 145 150 155 160 Asn Gly Trp Arg Arg Ile Asn Gln Tyr Gly Asn Asp His Leu Asp Asn 165 170 175 Glu Thr Asn Gly Ser Asn Cys Asp His His His His Asp Asp His Gly 180 185 190 Asp Ala Gly Gln Asp Leu Leu Ala Gln His Ser Arg Pro Arg Cys Gly 195 200 205 Thr Ser Gln Val Gly Phe Val Ser Asp Asn Arg Ser Ala Asn Pro Ile 210 215 220 Pro Tyr Ser His Phe Ser Thr Ile His Asn Pro Leu Ser Arg Ser Asn 225 230 235 240 Glu Ala Lys Thr Leu Glu Ser Lys Lys Arg Val Val Lys Met Leu Phe 245 250 255 Val Leu Val Leu Glu Phe Phe Ile Cys Trp Thr Pro Leu Tyr Val Ile 260 265 270 Asn Thr Met Val Met Leu Ile Gly Pro Val Val Tyr Glu Tyr Val Asp 275 280 285 Tyr Thr Ala Ile Ser Phe Leu Gln Leu Leu Ala Tyr Ser Ser Ser Cys 290 295 300 Cys Asn Pro Ile Thr Tyr Cys Phe Met Asn Ala Ser Phe Arg Arg Ala 305 310 315 320 Phe Val Asp Thr Phe Lys Gly Leu Pro Trp Arg Arg Gly Ala Gly Ala 325 330 335 Ser Gly Gly Val Gly Gly Ala Ala Gly Gly Gly Leu Ser Ala Ser Gln 340 345 350 Ala Gly Ala Gly Pro Gly Ala Tyr Ala Ser Ala Asn Thr Asn Ile Ser 355 360 365 Leu Asn Pro Gly Leu Ala Met Gly Met Gly Thr Trp Arg Ser Arg Ser 370 375 380 Arg His Glu Phe Leu Asn Ala Val Val Thr Thr Asn Ser Ala Ala Ala 385 390 395 400 Ala Val Asn Ser Pro Gln Leu 405 <210> SEQ ID NO 25 <211> LENGTH: 1258 <212> TYPE: DNA <213> ORGANISM: Drosophila melanogaster <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(1257) <400> SEQUENCE: 25 atg tcc gct ggc aat atg agc cat gat ctt gga ccg cca cgc gat ccg 48 Met Ser Ala Gly Asn Met Ser His Asp Leu Gly Pro Pro Arg Asp Pro 1 5 10 15 ctg gcc atc gtg ata ccc gta acg gtg gtc tac tcc ctc att ttc ata 96 Leu Ala Ile Val Ile Pro Val Thr Val Val Tyr Ser Leu Ile Phe Ile 20 25 30 acc ggt gta gtg ggc aac ata agt acc tgc att gtg att aag aag aac 144 Thr Gly Val Val Gly Asn Ile Ser Thr Cys Ile Val Ile Lys Lys Asn 35 40 45 cgt tca atg cac acg gcc acg aat tac tac ctc ttt tcg ctg gcc atc 192 Arg Ser Met His Thr Ala Thr Asn Tyr Tyr Leu Phe Ser Leu Ala Ile 50 55 60 tcg gat ttc ctg ctc ctg ttg tcg ggc gtt ccg cag gag gtg tcc tac 240 Ser Asp Phe Leu Leu Leu Leu Ser Gly Val Pro Gln Glu Val Ser Tyr 65 70 75 80 atc tgg tcc aag tac ccg tac gtg ttt ggg gag tac atc tgc atc gga 288 Ile Trp Ser Lys Tyr Pro Tyr Val Phe Gly Glu Tyr Ile Cys Ile Gly 85 90 95 cgt ggt ctg ttg gcg gag aca tcg gcg aat gcc acg gtg cta acg att 336 Arg Gly Leu Leu Ala Glu Thr Ser Ala Asn Ala Thr Val Leu Thr Ile 100 105 110 acg gcc ttc acg gtg gag cgg tat att gcc att tgc cat ccg ttt ctg 384 Thr Ala Phe Thr Val Glu Arg Tyr Ile Ala Ile Cys His Pro Phe Leu 115 120 125 ggc cag gcc atg agt aaa ctc agt cgc gcc att cgc atc atc gtc ctg 432 Gly Gln Ala Met Ser Lys Leu Ser Arg Ala Ile Arg Ile Ile Val Leu 130 135 140 gtt tgg att atg gcc ata gtt acg gcc att ccg cag gct gcc caa ttt 480 Val Trp Ile Met Ala Ile Val Thr Ala Ile Pro Gln Ala Ala Gln Phe 145 150 155 160 gga atc gag cac tat tcg gga gtg gag caa tgc ggc ata gtg cgg gtc 528 Gly Ile Glu His Tyr Ser Gly Val Glu Gln Cys Gly Ile Val Arg Val 165 170 175 ata gtg aag cac tca ttc cag ctg tcc acg ttc ata ttc ttc ctg gct 576 Ile Val Lys His Ser Phe Gln Leu Ser Thr Phe Ile Phe Phe Leu Ala 180 185 190 ccg atg tct att atc cta gtg ttg tac cta ctt atc ggt gtg cac ctg 624 Pro Met Ser Ile Ile Leu Val Leu Tyr Leu Leu Ile Gly Val His Leu 195 200 205 tat cga tcc act ttg gtg gag ggt cct gcc tcg gtt gcc aga cgg cag 672 Tyr Arg Ser Thr Leu Val Glu Gly Pro Ala Ser Val Ala Arg Arg Gln 210 215 220 cag ctg aag agt gtg ccc agt gat acg atc cta tat cgc tat ggt gga 720 Gln Leu Lys Ser Val Pro Ser Asp Thr Ile Leu Tyr Arg Tyr Gly Gly 225 230 235 240 tcc ggt acc gct atg agt ttc aac ggc gga gga agt gga gca ggg aca 768 Ser Gly Thr Ala Met Ser Phe Asn Gly Gly Gly Ser Gly Ala Gly Thr 245 250 255 gcg ggc ttg atg ggc ggc tcg ggg gct caa ctt agc tcg gtg aga ggt 816 Ala Gly Leu Met Gly Gly Ser Gly Ala Gln Leu Ser Ser Val Arg Gly 260 265 270 cgg ctc aat cac tat ggc acc cgg cga gta ctc agg atg cta gtg gcc 864 Arg Leu Asn His Tyr Gly Thr Arg Arg Val Leu Arg Met Leu Val Ala 275 280 285 gtg gtg gtg tgc ttc ttc ctc tgc tgg gcc ccc ttc cac gcc cag cga 912 Val Val Val Cys Phe Phe Leu Cys Trp Ala Pro Phe His Ala Gln Arg 290 295 300 ctg att gcc atc tac gcc cct gca cgg ggg gcc aaa ctg cgg gat cag 960 Leu Ile Ala Ile Tyr Ala Pro Ala Arg Gly Ala Lys Leu Arg Asp Gln 305 310 315 320 cac gag ttt gtc tac acg gtg atg acc tat gtc tcc ggt gtc ctc tac 1008 His Glu Phe Val Tyr Thr Val Met Thr Tyr Val Ser Gly Val Leu Tyr 325 330 335 tac ttg tcc acc tgc atc aac ccg ctg tta tat aac att atg agc cac 1056 Tyr Leu Ser Thr Cys Ile Asn Pro Leu Leu Tyr Asn Ile Met Ser His 340 345 350 aag ttc cga gag gca ttc aag gcc gtt ctg ttt ggc aag aag gta tcg 1104 Lys Phe Arg Glu Ala Phe Lys Ala Val Leu Phe Gly Lys Lys Val Ser 355 360 365 aag ggt tcg ctg aat tcg cga aac aac atc gaa tcg cgc cgc ctg agg 1152 Lys Gly Ser Leu Asn Ser Arg Asn Asn Ile Glu Ser Arg Arg Leu Arg 370 375 380 agg gca cta acc aat tcc agt caa acg cag cgc ttc tcc att gag tcg 1200 Arg Ala Leu Thr Asn Ser Ser Gln Thr Gln Arg Phe Ser Ile Glu Ser 385 390 395 400 gcg gag cag ccg aaa ccg tcg ata atg cag gca agt gcc ccc tat aat 1248 Ala Glu Gln Pro Lys Pro Ser Ile Met Gln Ala Ser Ala Pro Tyr Asn 405 410 415 caa tgg ata g 1258 Gln Trp Ile <210> SEQ ID NO 26 <211> LENGTH: 419 <212> TYPE: PRT <213> ORGANISM: Drosophila melanogaster <400> SEQUENCE: 26 Met Ser Ala Gly Asn Met Ser His Asp Leu Gly Pro Pro Arg Asp Pro 1 5 10 15 Leu Ala Ile Val Ile Pro Val Thr Val Val Tyr Ser Leu Ile Phe Ile 20 25 30 Thr Gly Val Val Gly Asn Ile Ser Thr Cys Ile Val Ile Lys Lys Asn 35 40 45 Arg Ser Met His Thr Ala Thr Asn Tyr Tyr Leu Phe Ser Leu Ala Ile 50 55 60 Ser Asp Phe Leu Leu Leu Leu Ser Gly Val Pro Gln Glu Val Ser Tyr 65 70 75 80 Ile Trp Ser Lys Tyr Pro Tyr Val Phe Gly Glu Tyr Ile Cys Ile Gly 85 90 95 Arg Gly Leu Leu Ala Glu Thr Ser Ala Asn Ala Thr Val Leu Thr Ile 100 105 110 Thr Ala Phe Thr Val Glu Arg Tyr Ile Ala Ile Cys His Pro Phe Leu 115 120 125 Gly Gln Ala Met Ser Lys Leu Ser Arg Ala Ile Arg Ile Ile Val Leu 130 135 140 Val Trp Ile Met Ala Ile Val Thr Ala Ile Pro Gln Ala Ala Gln Phe 145 150 155 160 Gly Ile Glu His Tyr Ser Gly Val Glu Gln Cys Gly Ile Val Arg Val 165 170 175 Ile Val Lys His Ser Phe Gln Leu Ser Thr Phe Ile Phe Phe Leu Ala 180 185 190 Pro Met Ser Ile Ile Leu Val Leu Tyr Leu Leu Ile Gly Val His Leu 195 200 205 Tyr Arg Ser Thr Leu Val Glu Gly Pro Ala Ser Val Ala Arg Arg Gln 210 215 220 Gln Leu Lys Ser Val Pro Ser Asp Thr Ile Leu Tyr Arg Tyr Gly Gly 225 230 235 240 Ser Gly Thr Ala Met Ser Phe Asn Gly Gly Gly Ser Gly Ala Gly Thr 245 250 255 Ala Gly Leu Met Gly Gly Ser Gly Ala Gln Leu Ser Ser Val Arg Gly 260 265 270 Arg Leu Asn His Tyr Gly Thr Arg Arg Val Leu Arg Met Leu Val Ala 275 280 285 Val Val Val Cys Phe Phe Leu Cys Trp Ala Pro Phe His Ala Gln Arg 290 295 300 Leu Ile Ala Ile Tyr Ala Pro Ala Arg Gly Ala Lys Leu Arg Asp Gln 305 310 315 320 His Glu Phe Val Tyr Thr Val Met Thr Tyr Val Ser Gly Val Leu Tyr 325 330 335 Tyr Leu Ser Thr Cys Ile Asn Pro Leu Leu Tyr Asn Ile Met Ser His 340 345 350 Lys Phe Arg Glu Ala Phe Lys Ala Val Leu Phe Gly Lys Lys Val Ser 355 360 365 Lys Gly Ser Leu Asn Ser Arg Asn Asn Ile Glu Ser Arg Arg Leu Arg 370 375 380 Arg Ala Leu Thr Asn Ser Ser Gln Thr Gln Arg Phe Ser Ile Glu Ser 385 390 395 400 Ala Glu Gln Pro Lys Pro Ser Ile Met Gln Ala Ser Ala Pro Tyr Asn 405 410 415 Gln Trp Ile <210> SEQ ID NO 27 <211> LENGTH: 1602 <212> TYPE: DNA <213> ORGANISM: Drosophila melanogaster <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(1599) <400> SEQUENCE: 27 atg gaa ggt gga tgg tgg cga gga gga gga gga gga gga cgt ttg ggc 48 Met Glu Gly Gly Trp Trp Arg Gly Gly Gly Gly Gly Gly Arg Leu Gly 1 5 10 15 ggg aaa gcc atc atg gaa gga cac tcg aca cca aat ggg gca gct gca 96 Gly Lys Ala Ile Met Glu Gly His Ser Thr Pro Asn Gly Ala Ala Ala 20 25 30 agc cac aga aac aac agc aca agg acc aat atc gcg acc aac ggc tgt 144 Ser His Arg Asn Asn Ser Thr Arg Thr Asn Ile Ala Thr Asn Gly Cys 35 40 45 gcc cat tcg ggc atc ctg tta ttt gtg ctg aca gct atg aca cta acg 192 Ala His Ser Gly Ile Leu Leu Phe Val Leu Thr Ala Met Thr Leu Thr 50 55 60 agc tta ata acg ccc aca gag cag ctg gca gtg gcg cca aat ggc acc 240 Ser Leu Ile Thr Pro Thr Glu Gln Leu Ala Val Ala Pro Asn Gly Thr 65 70 75 80 aca ctg cat caa ctg gag tcc gtg gag tcc gag tcg tat cca tcc ata 288 Thr Leu His Gln Leu Glu Ser Val Glu Ser Glu Ser Tyr Pro Ser Ile 85 90 95 aat ggc act cag aat gaa aca atg gtg acc agt gtg cga ccc cac ctg 336 Asn Gly Thr Gln Asn Glu Thr Met Val Thr Ser Val Arg Pro His Leu 100 105 110 gac cac agg aat cga ccg acg cag cag aat ggc agt cac tat ttg gag 384 Asp His Arg Asn Arg Pro Thr Gln Gln Asn Gly Ser His Tyr Leu Glu 115 120 125 tac gac gat gat ggc ccg gac tgt tcg tac agc tac aac ttc atc ctg 432 Tyr Asp Asp Asp Gly Pro Asp Cys Ser Tyr Ser Tyr Asn Phe Ile Leu 130 135 140 aag ctc atc acg atg atc ctg tac gca ctg gtc tgc atc att gga ctc 480 Lys Leu Ile Thr Met Ile Leu Tyr Ala Leu Val Cys Ile Ile Gly Leu 145 150 155 160 ttt ggc aac acc ctg gtg atc tat gtg gtg atg agg ttc tcc aag atg 528 Phe Gly Asn Thr Leu Val Ile Tyr Val Val Met Arg Phe Ser Lys Met 165 170 175 cag acc gta acc aac ata tac ata ctg aat ctg gct atc gcg gat gag 576 Gln Thr Val Thr Asn Ile Tyr Ile Leu Asn Leu Ala Ile Ala Asp Glu 180 185 190 tgc ttc ctg atc ggc att ccc ttc ctg ctc tac aca atg cag gtg ggc 624 Cys Phe Leu Ile Gly Ile Pro Phe Leu Leu Tyr Thr Met Gln Val Gly 195 200 205 aac tgg ccc ttc ggc aac tat atg tgc aag gcc tac atg gtg agc acc 672 Asn Trp Pro Phe Gly Asn Tyr Met Cys Lys Ala Tyr Met Val Ser Thr 210 215 220 tcg atc acc tcc ttc acc tcc tcg atc ttc ctg ttg atc atg tcg gcg 720 Ser Ile Thr Ser Phe Thr Ser Ser Ile Phe Leu Leu Ile Met Ser Ala 225 230 235 240 gat cgc tac ata gcc gtt tgc cat ccc ata tcc tcg cct cgc tac cga 768 Asp Arg Tyr Ile Ala Val Cys His Pro Ile Ser Ser Pro Arg Tyr Arg 245 250 255 acg ccc ttt gta tcc aag ttg gtt tcg gcc ttc gcc tgg atg aca tcc 816 Thr Pro Phe Val Ser Lys Leu Val Ser Ala Phe Ala Trp Met Thr Ser 260 265 270 gtg ctg ctg atg ctg ccg gtt atc ctt ttt gcc agc acc gtg cag tcg 864 Val Leu Leu Met Leu Pro Val Ile Leu Phe Ala Ser Thr Val Gln Ser 275 280 285 agc aac ggc aat gtg tcc tgc aac atc gag tgg cca gac act cag aac 912 Ser Asn Gly Asn Val Ser Cys Asn Ile Glu Trp Pro Asp Thr Gln Asn 290 295 300 tcg cac acc gac tcc acc ttc att ttg tac tcg ctg gtc ttg gga ttc 960 Ser His Thr Asp Ser Thr Phe Ile Leu Tyr Ser Leu Val Leu Gly Phe 305 310 315 320 gcc act cca ctg act ttt atc ctg gtg ttc tac tgc ctg gtg atc agg 1008 Ala Thr Pro Leu Thr Phe Ile Leu Val Phe Tyr Cys Leu Val Ile Arg 325 330 335 aaa ctt cac acc gtg gga ccg aag cac aag tct aag gag aag aag cgc 1056 Lys Leu His Thr Val Gly Pro Lys His Lys Ser Lys Glu Lys Lys Arg 340 345 350 tct cac agg aag gtc acc aag ttg gtg ctc acg gtg gct ttg atc agc 1104 Ser His Arg Lys Val Thr Lys Leu Val Leu Thr Val Ala Leu Ile Ser 355 360 365 tcc gct cct caa cgc tgt gca tct cgt ctg gag ctg gcc gtc ttc ctg 1152 Ser Ala Pro Gln Arg Cys Ala Ser Arg Leu Glu Leu Ala Val Phe Leu 370 375 380 gcc tgc gga tgc ctc agc tac tcc aac tcg gcc atg aac cca ata ctg 1200 Ala Cys Gly Cys Leu Ser Tyr Ser Asn Ser Ala Met Asn Pro Ile Leu 385 390 395 400 tac gcc ttt ttg agc gat aac ttc aag aag agc ttc atg aag gcc tgc 1248 Tyr Ala Phe Leu Ser Asp Asn Phe Lys Lys Ser Phe Met Lys Ala Cys 405 410 415 acg tgt gct gcc cgc aag gat gtg aat gcc cag ttg cag ctg gag aac 1296 Thr Cys Ala Ala Arg Lys Asp Val Asn Ala Gln Leu Gln Leu Glu Asn 420 425 430 agt ttc ttc ccc aag ttt ggc aag ggc agg caa tcg gag cgt ctt ctt 1344 Ser Phe Phe Pro Lys Phe Gly Lys Gly Arg Gln Ser Glu Arg Leu Leu 435 440 445 ggt ggc aat gga aaa ggt ggc gcc cag cgt ggg gca tta acc aag aag 1392 Gly Gly Asn Gly Lys Gly Gly Ala Gln Arg Gly Ala Leu Thr Lys Lys 450 455 460 aag tgc ttg gcg acg aga aac aac aat gct ccg atg gcc act aca acg 1440 Lys Cys Leu Ala Thr Arg Asn Asn Asn Ala Pro Met Ala Thr Thr Thr 465 470 475 480 acg acg aca acc acc aca acg ggc acg gat gca gtg acc tgt ctc cag 1488 Thr Thr Thr Thr Thr Thr Thr Gly Thr Asp Ala Val Thr Cys Leu Gln 485 490 495 ccg cca gta cac cag gtg cca gcc gag atc cag gtg gga aat ccg gcc 1536 Pro Pro Val His Gln Val Pro Ala Glu Ile Gln Val Gly Asn Pro Ala 500 505 510 acc gtg ctg gtg gtc aat gct gag acc aac aac tgt aaa ccg ccc gtg 1584 Thr Val Leu Val Val Asn Ala Glu Thr Asn Asn Cys Lys Pro Pro Val 515 520 525 ctc cac acg gac tta taa 1602 Leu His Thr Asp Leu 530 <210> SEQ ID NO 28 <211> LENGTH: 533 <212> TYPE: PRT <213> ORGANISM: Drosophila melanogaster <400> SEQUENCE: 28 Met Glu Gly Gly Trp Trp Arg Gly Gly Gly Gly Gly Gly Arg Leu Gly 1 5 10 15 Gly Lys Ala Ile Met Glu Gly His Ser Thr Pro Asn Gly Ala Ala Ala 20 25 30 Ser His Arg Asn Asn Ser Thr Arg Thr Asn Ile Ala Thr Asn Gly Cys 35 40 45 Ala His Ser Gly Ile Leu Leu Phe Val Leu Thr Ala Met Thr Leu Thr 50 55 60 Ser Leu Ile Thr Pro Thr Glu Gln Leu Ala Val Ala Pro Asn Gly Thr 65 70 75 80 Thr Leu His Gln Leu Glu Ser Val Glu Ser Glu Ser Tyr Pro Ser Ile 85 90 95 Asn Gly Thr Gln Asn Glu Thr Met Val Thr Ser Val Arg Pro His Leu 100 105 110 Asp His Arg Asn Arg Pro Thr Gln Gln Asn Gly Ser His Tyr Leu Glu 115 120 125 Tyr Asp Asp Asp Gly Pro Asp Cys Ser Tyr Ser Tyr Asn Phe Ile Leu 130 135 140 Lys Leu Ile Thr Met Ile Leu Tyr Ala Leu Val Cys Ile Ile Gly Leu 145 150 155 160 Phe Gly Asn Thr Leu Val Ile Tyr Val Val Met Arg Phe Ser Lys Met 165 170 175 Gln Thr Val Thr Asn Ile Tyr Ile Leu Asn Leu Ala Ile Ala Asp Glu 180 185 190 Cys Phe Leu Ile Gly Ile Pro Phe Leu Leu Tyr Thr Met Gln Val Gly 195 200 205 Asn Trp Pro Phe Gly Asn Tyr Met Cys Lys Ala Tyr Met Val Ser Thr 210 215 220 Ser Ile Thr Ser Phe Thr Ser Ser Ile Phe Leu Leu Ile Met Ser Ala 225 230 235 240 Asp Arg Tyr Ile Ala Val Cys His Pro Ile Ser Ser Pro Arg Tyr Arg 245 250 255 Thr Pro Phe Val Ser Lys Leu Val Ser Ala Phe Ala Trp Met Thr Ser 260 265 270 Val Leu Leu Met Leu Pro Val Ile Leu Phe Ala Ser Thr Val Gln Ser 275 280 285 Ser Asn Gly Asn Val Ser Cys Asn Ile Glu Trp Pro Asp Thr Gln Asn 290 295 300 Ser His Thr Asp Ser Thr Phe Ile Leu Tyr Ser Leu Val Leu Gly Phe 305 310 315 320 Ala Thr Pro Leu Thr Phe Ile Leu Val Phe Tyr Cys Leu Val Ile Arg 325 330 335 Lys Leu His Thr Val Gly Pro Lys His Lys Ser Lys Glu Lys Lys Arg 340 345 350 Ser His Arg Lys Val Thr Lys Leu Val Leu Thr Val Ala Leu Ile Ser 355 360 365 Ser Ala Pro Gln Arg Cys Ala Ser Arg Leu Glu Leu Ala Val Phe Leu 370 375 380 Ala Cys Gly Cys Leu Ser Tyr Ser Asn Ser Ala Met Asn Pro Ile Leu 385 390 395 400 Tyr Ala Phe Leu Ser Asp Asn Phe Lys Lys Ser Phe Met Lys Ala Cys 405 410 415 Thr Cys Ala Ala Arg Lys Asp Val Asn Ala Gln Leu Gln Leu Glu Asn 420 425 430 Ser Phe Phe Pro Lys Phe Gly Lys Gly Arg Gln Ser Glu Arg Leu Leu 435 440 445 Gly Gly Asn Gly Lys Gly Gly Ala Gln Arg Gly Ala Leu Thr Lys Lys 450 455 460 Lys Cys Leu Ala Thr Arg Asn Asn Asn Ala Pro Met Ala Thr Thr Thr 465 470 475 480 Thr Thr Thr Thr Thr Thr Thr Gly Thr Asp Ala Val Thr Cys Leu Gln 485 490 495 Pro Pro Val His Gln Val Pro Ala Glu Ile Gln Val Gly Asn Pro Ala 500 505 510 Thr Val Leu Val Val Asn Ala Glu Thr Asn Asn Cys Lys Pro Pro Val 515 520 525 Leu His Thr Asp Leu 530 <210> SEQ ID NO 29 <211> LENGTH: 1347 <212> TYPE: DNA <213> ORGANISM: Drosophila melanogaster <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(1344) <400> SEQUENCE: 29 atg ttt cta tat aag aat tgt tac aat ttt aga ttt gag tgc tat gaa 48 Met Phe Leu Tyr Lys Asn Cys Tyr Asn Phe Arg Phe Glu Cys Tyr Glu 1 5 10 15 ttg aat ttc gaa tgc ctg gag tat aag ttc tat aaa tta aat acc aag 96 Leu Asn Phe Glu Cys Leu Glu Tyr Lys Phe Tyr Lys Leu Asn Thr Lys 20 25 30 cca cgc att ttg agc tgt gaa act gcc tta aaa gtc gaa aga aat att 144 Pro Arg Ile Leu Ser Cys Glu Thr Ala Leu Lys Val Glu Arg Asn Ile 35 40 45 ttt cga agt gca ggt cct tca tct tgg cag caa ttt cct gct gga ata 192 Phe Arg Ser Ala Gly Pro Ser Ser Trp Gln Gln Phe Pro Ala Gly Ile 50 55 60 acg gtg gct gtc tgt ctt cca tca cgt ctg ggt gtg tgg acc gaa cag 240 Thr Val Ala Val Cys Leu Pro Ser Arg Leu Gly Val Trp Thr Glu Gln 65 70 75 80 ttt gct gtg ctc tgg atc ctg ttc acc gtc atc gtt ctg ggc aat tca 288 Phe Ala Val Leu Trp Ile Leu Phe Thr Val Ile Val Leu Gly Asn Ser 85 90 95 gct gtt ctg ttc gtg atg ttc atc aac aag aat cgc aag tcg cgg atg 336 Ala Val Leu Phe Val Met Phe Ile Asn Lys Asn Arg Lys Ser Arg Met 100 105 110 aac tac ttc att aaa cag ctg gca ttg gca gat ctg tgc gtg gga ctg 384 Asn Tyr Phe Ile Lys Gln Leu Ala Leu Ala Asp Leu Cys Val Gly Leu 115 120 125 ctc aac gtc ctc acc gac atc ata tgg cgc atc acg att tcg tgg cgg 432 Leu Asn Val Leu Thr Asp Ile Ile Trp Arg Ile Thr Ile Ser Trp Arg 130 135 140 gca ggc aac ctg gcc tgc aag gcc atc cgc ttc tcg cag gtc tgc gtc 480 Ala Gly Asn Leu Ala Cys Lys Ala Ile Arg Phe Ser Gln Val Cys Val 145 150 155 160 aca tac tcg tcc acc tac gtg ctg gtg gcc atg agc atc gac aga tac 528 Thr Tyr Ser Ser Thr Tyr Val Leu Val Ala Met Ser Ile Asp Arg Tyr 165 170 175 gat gcc atc aca cac ccc atg aac ttc tca aag tcg tgg aaa aga gcc 576 Asp Ala Ile Thr His Pro Met Asn Phe Ser Lys Ser Trp Lys Arg Ala 180 185 190 cgt cac ctg gtg gct ggc gca tgg ctc atc tcg gcg ttg ttt tcg ctt 624 Arg His Leu Val Ala Gly Ala Trp Leu Ile Ser Ala Leu Phe Ser Leu 195 200 205 ccc atc ctg gtt ttg tac gag gag aag ctc atc caa gga cat ccg caa 672 Pro Ile Leu Val Leu Tyr Glu Glu Lys Leu Ile Gln Gly His Pro Gln 210 215 220 tgc tgg att gag ttg ggt tca ccg atc gcc tgg cag gtg tac atg agc 720 Cys Trp Ile Glu Leu Gly Ser Pro Ile Ala Trp Gln Val Tyr Met Ser 225 230 235 240 ctg gtg tcg gcc act cta ttt gcc att cct gcg ctg atc ata tct gcc 768 Leu Val Ser Ala Thr Leu Phe Ala Ile Pro Ala Leu Ile Ile Ser Ala 245 250 255 tgc tat gcg atc atc gta aag acg att tgg gca aag ggt tcc att ttt 816 Cys Tyr Ala Ile Ile Val Lys Thr Ile Trp Ala Lys Gly Ser Ile Phe 260 265 270 gta ccc acg gaa cgt gct ggt ttt gga gct gca cct gcc agg agg gcc 864 Val Pro Thr Glu Arg Ala Gly Phe Gly Ala Ala Pro Ala Arg Arg Ala 275 280 285 agc tcg agg ggc att att cca cgg gca aag gtc aaa acg gtc aag atg 912 Ser Ser Arg Gly Ile Ile Pro Arg Ala Lys Val Lys Thr Val Lys Met 290 295 300 aca ttg acc atc gtg ttt gtg ttc atc atc tgc tgg tcg ccg tat atc 960 Thr Leu Thr Ile Val Phe Val Phe Ile Ile Cys Trp Ser Pro Tyr Ile 305 310 315 320 atc ttc gat ctg ctg cag gtc ttt ggc cag att cca cac tca cag acc 1008 Ile Phe Asp Leu Leu Gln Val Phe Gly Gln Ile Pro His Ser Gln Thr 325 330 335 aac att gcc atc gcc acc ttc atc caa agt ctg gca ccg ctg aac tcg 1056 Asn Ile Ala Ile Ala Thr Phe Ile Gln Ser Leu Ala Pro Leu Asn Ser 340 345 350 gcg gcg aat cca cta atc tat tgc ctc ttc tca tcg cag gtc ttt cgc 1104 Ala Ala Asn Pro Leu Ile Tyr Cys Leu Phe Ser Ser Gln Val Phe Arg 355 360 365 aca tta agt cgc ttt ccg cct ttt aag tgg ttc aca tgc tgc tgc aag 1152 Thr Leu Ser Arg Phe Pro Pro Phe Lys Trp Phe Thr Cys Cys Cys Lys 370 375 380 tca tac cgc aac aac tcg cag caa aac cgc tgc cac acg gtt ggt cgt 1200 Ser Tyr Arg Asn Asn Ser Gln Gln Asn Arg Cys His Thr Val Gly Arg 385 390 395 400 cgg ctt cac aac agt tgc gat tcg atg agg aca ctg acc act tcg ttg 1248 Arg Leu His Asn Ser Cys Asp Ser Met Arg Thr Leu Thr Thr Ser Leu 405 410 415 acg gtt tcc cga agg tcc acc aac aag acg aac gcc cgt gtg gta atc 1296 Thr Val Ser Arg Arg Ser Thr Asn Lys Thr Asn Ala Arg Val Val Ile 420 425 430 tgc gaa cgt ccc acc aag gtg gtt acc gtg cca gcc atg tcg gag gta 1344 Cys Glu Arg Pro Thr Lys Val Val Thr Val Pro Ala Met Ser Glu Val 435 440 445 tga 1347 <210> SEQ ID NO 30 <211> LENGTH: 448 <212> TYPE: PRT <213> ORGANISM: Drosophila melanogaster <400> SEQUENCE: 30 Met Phe Leu Tyr Lys Asn Cys Tyr Asn Phe Arg Phe Glu Cys Tyr Glu 1 5 10 15 Leu Asn Phe Glu Cys Leu Glu Tyr Lys Phe Tyr Lys Leu Asn Thr Lys 20 25 30 Pro Arg Ile Leu Ser Cys Glu Thr Ala Leu Lys Val Glu Arg Asn Ile 35 40 45 Phe Arg Ser Ala Gly Pro Ser Ser Trp Gln Gln Phe Pro Ala Gly Ile 50 55 60 Thr Val Ala Val Cys Leu Pro Ser Arg Leu Gly Val Trp Thr Glu Gln 65 70 75 80 Phe Ala Val Leu Trp Ile Leu Phe Thr Val Ile Val Leu Gly Asn Ser 85 90 95 Ala Val Leu Phe Val Met Phe Ile Asn Lys Asn Arg Lys Ser Arg Met 100 105 110 Asn Tyr Phe Ile Lys Gln Leu Ala Leu Ala Asp Leu Cys Val Gly Leu 115 120 125 Leu Asn Val Leu Thr Asp Ile Ile Trp Arg Ile Thr Ile Ser Trp Arg 130 135 140 Ala Gly Asn Leu Ala Cys Lys Ala Ile Arg Phe Ser Gln Val Cys Val 145 150 155 160 Thr Tyr Ser Ser Thr Tyr Val Leu Val Ala Met Ser Ile Asp Arg Tyr 165 170 175 Asp Ala Ile Thr His Pro Met Asn Phe Ser Lys Ser Trp Lys Arg Ala 180 185 190 Arg His Leu Val Ala Gly Ala Trp Leu Ile Ser Ala Leu Phe Ser Leu 195 200 205 Pro Ile Leu Val Leu Tyr Glu Glu Lys Leu Ile Gln Gly His Pro Gln 210 215 220 Cys Trp Ile Glu Leu Gly Ser Pro Ile Ala Trp Gln Val Tyr Met Ser 225 230 235 240 Leu Val Ser Ala Thr Leu Phe Ala Ile Pro Ala Leu Ile Ile Ser Ala 245 250 255 Cys Tyr Ala Ile Ile Val Lys Thr Ile Trp Ala Lys Gly Ser Ile Phe 260 265 270 Val Pro Thr Glu Arg Ala Gly Phe Gly Ala Ala Pro Ala Arg Arg Ala 275 280 285 Ser Ser Arg Gly Ile Ile Pro Arg Ala Lys Val Lys Thr Val Lys Met 290 295 300 Thr Leu Thr Ile Val Phe Val Phe Ile Ile Cys Trp Ser Pro Tyr Ile 305 310 315 320 Ile Phe Asp Leu Leu Gln Val Phe Gly Gln Ile Pro His Ser Gln Thr 325 330 335 Asn Ile Ala Ile Ala Thr Phe Ile Gln Ser Leu Ala Pro Leu Asn Ser 340 345 350 Ala Ala Asn Pro Leu Ile Tyr Cys Leu Phe Ser Ser Gln Val Phe Arg 355 360 365 Thr Leu Ser Arg Phe Pro Pro Phe Lys Trp Phe Thr Cys Cys Cys Lys 370 375 380 Ser Tyr Arg Asn Asn Ser Gln Gln Asn Arg Cys His Thr Val Gly Arg 385 390 395 400 Arg Leu His Asn Ser Cys Asp Ser Met Arg Thr Leu Thr Thr Ser Leu 405 410 415 Thr Val Ser Arg Arg Ser Thr Asn Lys Thr Asn Ala Arg Val Val Ile 420 425 430 Cys Glu Arg Pro Thr Lys Val Val Thr Val Pro Ala Met Ser Glu Val 435 440 445 <210> SEQ ID NO 31 <211> LENGTH: 1449 <212> TYPE: DNA <213> ORGANISM: Drosophila melanogaster <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(1446) <400> SEQUENCE: 31 atg aac gag ggc gtt att gac atg cga aac gtg gac gag gag ctg gcg 48 Met Asn Glu Gly Val Ile Asp Met Arg Asn Val Asp Glu Glu Leu Ala 1 5 10 15 gag aag gag gag ctg atg gcc acc gtc gtc agt gcc acg atg gcc aca 96 Glu Lys Glu Glu Leu Met Ala Thr Val Val Ser Ala Thr Met Ala Thr 20 25 30 aat cag gag gag aac cga ctc ttt tgc ccc ctg aac ttt gac gga tat 144 Asn Gln Glu Glu Asn Arg Leu Phe Cys Pro Leu Asn Phe Asp Gly Tyr 35 40 45 ctc tgc tgg cca agg act ccg gcc ggc act gtg ctg agt caa tat tgt 192 Leu Cys Trp Pro Arg Thr Pro Ala Gly Thr Val Leu Ser Gln Tyr Cys 50 55 60 ccc gat ttc gtc gaa gga ttc aac aga aaa ttt ctg gcc cac aag acc 240 Pro Asp Phe Val Glu Gly Phe Asn Arg Lys Phe Leu Ala His Lys Thr 65 70 75 80 tgc ctg gag aac ggc tcc tgg tac cgt cat ccg gtt agc aat cag acc 288 Cys Leu Glu Asn Gly Ser Trp Tyr Arg His Pro Val Ser Asn Gln Thr 85 90 95 tgg tcc aat tac acc aac tgc gtg gac tat gag gac ctg gag ttt cgc 336 Trp Ser Asn Tyr Thr Asn Cys Val Asp Tyr Glu Asp Leu Glu Phe Arg 100 105 110 cag ttc atc aac gag ctg tac gtg aag ggt tat gcc ctc tcc ctg ctg 384 Gln Phe Ile Asn Glu Leu Tyr Val Lys Gly Tyr Ala Leu Ser Leu Leu 115 120 125 gcc ctg ctc ata tcg att att att ttc ttg ggc ttc aaa tcc ctg cgc 432 Ala Leu Leu Ile Ser Ile Ile Ile Phe Leu Gly Phe Lys Ser Leu Arg 130 135 140 tgc acc cgc atc cgc atc cat gta cat ctg ttc gcc tcg ctg gcc tgc 480 Cys Thr Arg Ile Arg Ile His Val His Leu Phe Ala Ser Leu Ala Cys 145 150 155 160 acc tgt gtg gcc tgg ata tta tgg tat cgt ctg gtg gtg gag cgt tcc 528 Thr Cys Val Ala Trp Ile Leu Trp Tyr Arg Leu Val Val Glu Arg Ser 165 170 175 gaa acc ata gcc gaa aat ccg gta aga tgc act gag aaa agt aac tat 576 Glu Thr Ile Ala Glu Asn Pro Val Arg Cys Thr Glu Lys Ser Asn Tyr 180 185 190 gaa aat aac ata gcc cta caa gta gct agg caa tta tac aaa acc ata 624 Glu Asn Asn Ile Ala Leu Gln Val Ala Arg Gln Leu Tyr Lys Thr Ile 195 200 205 aac ata act aac ttt cag ctg tgg tgc att ggg ctg cat ctg gtg gtg 672 Asn Ile Thr Asn Phe Gln Leu Trp Cys Ile Gly Leu His Leu Val Val 210 215 220 cac tac ttt atg ttg gtc aac tat ttc tgg atg ttt tgc gag ggc ctg 720 His Tyr Phe Met Leu Val Asn Tyr Phe Trp Met Phe Cys Glu Gly Leu 225 230 235 240 cac ctg cac ctg gtg ctc gtt gtg gtg agt tat cct tac tcg tct ggc 768 His Leu His Leu Val Leu Val Val Val Ser Tyr Pro Tyr Ser Ser Gly 245 250 255 aat ctg gca att gcc tgc aca agt ctg cat tct tta tgg gcg act tct 816 Asn Leu Ala Ile Ala Cys Thr Ser Leu His Ser Leu Trp Ala Thr Ser 260 265 270 gtg cat ggc aga tgt gat ttc ctg cag ccg ctg aca tgg caa tgg ttc 864 Val His Gly Arg Cys Asp Phe Leu Gln Pro Leu Thr Trp Gln Trp Phe 275 280 285 acc ccc agc aat ttg tct gag agc aaa tcg caa cgt tgg cca act gct 912 Thr Pro Ser Asn Leu Ser Glu Ser Lys Ser Gln Arg Trp Pro Thr Ala 290 295 300 tta cgt ctg cgt caa gtt gag atg tca gga atg tcc gtt cag atc ctg 960 Leu Arg Leu Arg Gln Val Glu Met Ser Gly Met Ser Val Gln Ile Leu 305 310 315 320 acg ccc ctt ctt ctt tcc att cgc cag gtc ttt gtc aag gac acg att 1008 Thr Pro Leu Leu Leu Ser Ile Arg Gln Val Phe Val Lys Asp Thr Ile 325 330 335 gtg atg cgc tgg ttt att gtc atc agc tgg ttt tca ccc ata ccc ata 1056 Val Met Arg Trp Phe Ile Val Ile Ser Trp Phe Ser Pro Ile Pro Ile 340 345 350 gcc atc gtc tac gtt ttt ctg atc aac gta ctg cga gtg atc gtg cga 1104 Ala Ile Val Tyr Val Phe Leu Ile Asn Val Leu Arg Val Ile Val Arg 355 360 365 aag tta cat ccc cag tcc gcc cag ccg gca ccg ttg gcc atc cgg aag 1152 Lys Leu His Pro Gln Ser Ala Gln Pro Ala Pro Leu Ala Ile Arg Lys 370 375 380 gcg gtt cgg gcc acc att att ctg gta ccg ctg ttc gga ctg caa cac 1200 Ala Val Arg Ala Thr Ile Ile Leu Val Pro Leu Phe Gly Leu Gln His 385 390 395 400 ttc ctg ctg ccc tac cgt ccg gat gcc ggc acc cag ctg gac cac ttc 1248 Phe Leu Leu Pro Tyr Arg Pro Asp Ala Gly Thr Gln Leu Asp His Phe 405 410 415 tat cag atg cta tcg gtg gtg ttg gtc agc ctg cag ggc ttt gtg gtc 1296 Tyr Gln Met Leu Ser Val Val Leu Val Ser Leu Gln Gly Phe Val Val 420 425 430 tcc ttc ctg ttc tgc ttc gcc aat cac gat gtc acc ttt gcc att cgc 1344 Ser Phe Leu Phe Cys Phe Ala Asn His Asp Val Thr Phe Ala Ile Arg 435 440 445 acg ctg ctg aac aag ttg ctg ccc agt tta gtg acc ccg ccg ccg gcc 1392 Thr Leu Leu Asn Lys Leu Leu Pro Ser Leu Val Thr Pro Pro Pro Ala 450 455 460 ggg agt aat act gga cag atg gcc acg acc acg ccc agc cga gag ttg 1440 Gly Ser Asn Thr Gly Gln Met Ala Thr Thr Thr Pro Ser Arg Glu Leu 465 470 475 480 ggc gtt taa 1449 Gly Val <210> SEQ ID NO 32 <211> LENGTH: 482 <212> TYPE: PRT <213> ORGANISM: Drosophila melanogaster <400> SEQUENCE: 32 Met Asn Glu Gly Val Ile Asp Met Arg Asn Val Asp Glu Glu Leu Ala 1 5 10 15 Glu Lys Glu Glu Leu Met Ala Thr Val Val Ser Ala Thr Met Ala Thr 20 25 30 Asn Gln Glu Glu Asn Arg Leu Phe Cys Pro Leu Asn Phe Asp Gly Tyr 35 40 45 Leu Cys Trp Pro Arg Thr Pro Ala Gly Thr Val Leu Ser Gln Tyr Cys 50 55 60 Pro Asp Phe Val Glu Gly Phe Asn Arg Lys Phe Leu Ala His Lys Thr 65 70 75 80 Cys Leu Glu Asn Gly Ser Trp Tyr Arg His Pro Val Ser Asn Gln Thr 85 90 95 Trp Ser Asn Tyr Thr Asn Cys Val Asp Tyr Glu Asp Leu Glu Phe Arg 100 105 110 Gln Phe Ile Asn Glu Leu Tyr Val Lys Gly Tyr Ala Leu Ser Leu Leu 115 120 125 Ala Leu Leu Ile Ser Ile Ile Ile Phe Leu Gly Phe Lys Ser Leu Arg 130 135 140 Cys Thr Arg Ile Arg Ile His Val His Leu Phe Ala Ser Leu Ala Cys 145 150 155 160 Thr Cys Val Ala Trp Ile Leu Trp Tyr Arg Leu Val Val Glu Arg Ser 165 170 175 Glu Thr Ile Ala Glu Asn Pro Val Arg Cys Thr Glu Lys Ser Asn Tyr 180 185 190 Glu Asn Asn Ile Ala Leu Gln Val Ala Arg Gln Leu Tyr Lys Thr Ile 195 200 205 Asn Ile Thr Asn Phe Gln Leu Trp Cys Ile Gly Leu His Leu Val Val 210 215 220 His Tyr Phe Met Leu Val Asn Tyr Phe Trp Met Phe Cys Glu Gly Leu 225 230 235 240 His Leu His Leu Val Leu Val Val Val Ser Tyr Pro Tyr Ser Ser Gly 245 250 255 Asn Leu Ala Ile Ala Cys Thr Ser Leu His Ser Leu Trp Ala Thr Ser 260 265 270 Val His Gly Arg Cys Asp Phe Leu Gln Pro Leu Thr Trp Gln Trp Phe 275 280 285 Thr Pro Ser Asn Leu Ser Glu Ser Lys Ser Gln Arg Trp Pro Thr Ala 290 295 300 Leu Arg Leu Arg Gln Val Glu Met Ser Gly Met Ser Val Gln Ile Leu 305 310 315 320 Thr Pro Leu Leu Leu Ser Ile Arg Gln Val Phe Val Lys Asp Thr Ile 325 330 335 Val Met Arg Trp Phe Ile Val Ile Ser Trp Phe Ser Pro Ile Pro Ile 340 345 350 Ala Ile Val Tyr Val Phe Leu Ile Asn Val Leu Arg Val Ile Val Arg 355 360 365 Lys Leu His Pro Gln Ser Ala Gln Pro Ala Pro Leu Ala Ile Arg Lys 370 375 380 Ala Val Arg Ala Thr Ile Ile Leu Val Pro Leu Phe Gly Leu Gln His 385 390 395 400 Phe Leu Leu Pro Tyr Arg Pro Asp Ala Gly Thr Gln Leu Asp His Phe 405 410 415 Tyr Gln Met Leu Ser Val Val Leu Val Ser Leu Gln Gly Phe Val Val 420 425 430 Ser Phe Leu Phe Cys Phe Ala Asn His Asp Val Thr Phe Ala Ile Arg 435 440 445 Thr Leu Leu Asn Lys Leu Leu Pro Ser Leu Val Thr Pro Pro Pro Ala 450 455 460 Gly Ser Asn Thr Gly Gln Met Ala Thr Thr Thr Pro Ser Arg Glu Leu 465 470 475 480 Gly Val <210> SEQ ID NO 33 <211> LENGTH: 1521 <212> TYPE: DNA <213> ORGANISM: Drosophila melanogaster <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(1518) <221> NAME/KEY: n <222> LOCATION: 1521 <223> OTHER INFORMATION: n is a or g or c or t/u, unknown, or other <400> SEQUENCE: 33 atg tac gcc tcc ttg atg gac gtt ggc cag acg ttg gca gcc agg ctg 48 Met Tyr Ala Ser Leu Met Asp Val Gly Gln Thr Leu Ala Ala Arg Leu 1 5 10 15 gcg gat agc gac ggc aac ggg gcc aat gac agc gga ctc ctg gca acc 96 Ala Asp Ser Asp Gly Asn Gly Ala Asn Asp Ser Gly Leu Leu Ala Thr 20 25 30 gga caa ggt ctg gag cag gag cag gag ggt ctg gca ctg gat atg ggc 144 Gly Gln Gly Leu Glu Gln Glu Gln Glu Gly Leu Ala Leu Asp Met Gly 35 40 45 cac aat gcc agc gcc gac ggc gga ata gta ccg tat gtg ccc gtg ctg 192 His Asn Ala Ser Ala Asp Gly Gly Ile Val Pro Tyr Val Pro Val Leu 50 55 60 gac cgc ccg gag acg tac att gtc acc gtg ctg tac acg ctc atc ttc 240 Asp Arg Pro Glu Thr Tyr Ile Val Thr Val Leu Tyr Thr Leu Ile Phe 65 70 75 80 att gtg gga gtt ttg ggc aac ggc acg ctg gtc atc atc ttc ttt cgc 288 Ile Val Gly Val Leu Gly Asn Gly Thr Leu Val Ile Ile Phe Phe Arg 85 90 95 cac cgc tcc atg cgc aac ata ccc aac aca tac att ctt tca ctg gcc 336 His Arg Ser Met Arg Asn Ile Pro Asn Thr Tyr Ile Leu Ser Leu Ala 100 105 110 ctg gct gat ctg ttg gtt ata ttg gtg tgt gta cct gtg gcc acg att 384 Leu Ala Asp Leu Leu Val Ile Leu Val Cys Val Pro Val Ala Thr Ile 115 120 125 gtc tac acg cag gaa agc tgg ccc ttt gag cgg aac atg tgc cgc atc 432 Val Tyr Thr Gln Glu Ser Trp Pro Phe Glu Arg Asn Met Cys Arg Ile 130 135 140 agc gag ttc ttt aag gac ata tcc atc ggg gtg tcc gtg ttt aca ctg 480 Ser Glu Phe Phe Lys Asp Ile Ser Ile Gly Val Ser Val Phe Thr Leu 145 150 155 160 acc gcc ctt tcc ggc gag cgg tac tgc gcc att gta aat ccc cta cgc 528 Thr Ala Leu Ser Gly Glu Arg Tyr Cys Ala Ile Val Asn Pro Leu Arg 165 170 175 aag ctt cag acc aag ccg ctc act gtc ttt act gcg gtg atg atc tgg 576 Lys Leu Gln Thr Lys Pro Leu Thr Val Phe Thr Ala Val Met Ile Trp 180 185 190 atc ctg gcc atc cta ctg ggc atg cct tcg gtt ctt ttc tcc gac atc 624 Ile Leu Ala Ile Leu Leu Gly Met Pro Ser Val Leu Phe Ser Asp Ile 195 200 205 aag tcc tac cct gtg ttc aca gcc acc ggt aac atg acc att gaa gtg 672 Lys Ser Tyr Pro Val Phe Thr Ala Thr Gly Asn Met Thr Ile Glu Val 210 215 220 tgc tcc cca ttt cgc gac ccg gag tat gca aag ttc atg gtg gcg ggc 720 Cys Ser Pro Phe Arg Asp Pro Glu Tyr Ala Lys Phe Met Val Ala Gly 225 230 235 240 aag gca ctg gtg tac tac ctg ttg ccg ctg tcc atc att ggg gcg cta 768 Lys Ala Leu Val Tyr Tyr Leu Leu Pro Leu Ser Ile Ile Gly Ala Leu 245 250 255 tac atc atg atg gcc aag cgg ctc cat atg agc gcc cgc aac atg ccc 816 Tyr Ile Met Met Ala Lys Arg Leu His Met Ser Ala Arg Asn Met Pro 260 265 270 ggc gaa cag cag agc atg cag agc cgc acc cag gct agg gcc cga ctc 864 Gly Glu Gln Gln Ser Met Gln Ser Arg Thr Gln Ala Arg Ala Arg Leu 275 280 285 cat gtg gcg cgc atg gtg gta gca ttc gtg gtg gtg ttc ttc atc tgc 912 His Val Ala Arg Met Val Val Ala Phe Val Val Val Phe Phe Ile Cys 290 295 300 ttc ttc ccg tac cac gtg ttt gag ctg tgg tac cac ttc tac cca acg 960 Phe Phe Pro Tyr His Val Phe Glu Leu Trp Tyr His Phe Tyr Pro Thr 305 310 315 320 gct gag gag gac ttc gat gag ttc tgg aac gtg ctg cgc atc gtt gga 1008 Ala Glu Glu Asp Phe Asp Glu Phe Trp Asn Val Leu Arg Ile Val Gly 325 330 335 ttt tgc acg agc gca gta aaa ctc aaa aat aat gtg tca gca att tgg 1056 Phe Cys Thr Ser Ala Val Lys Leu Lys Asn Asn Val Ser Ala Ile Trp 340 345 350 tgg ctt aat tca ctg ccg ctc gtc gtc aaa gcc att tgc att ctg gcc 1104 Trp Leu Asn Ser Leu Pro Leu Val Val Lys Ala Ile Cys Ile Leu Ala 355 360 365 aaa tgg ctt cct aaa ctc gtg cgt caa ccc cgt ggc ctc tac tgc gtg 1152 Lys Trp Leu Pro Lys Leu Val Arg Gln Pro Arg Gly Leu Tyr Cys Val 370 375 380 tcc ggg gtg ttt cgg cag cac ttt aat cgc tac ctc tgc tgc atc tgc 1200 Ser Gly Val Phe Arg Gln His Phe Asn Arg Tyr Leu Cys Cys Ile Cys 385 390 395 400 gtc aag cgg cag ccg cac ctg cgg cag cac tca acg gcc act gga atg 1248 Val Lys Arg Gln Pro His Leu Arg Gln His Ser Thr Ala Thr Gly Met 405 410 415 atg gac aat acc agt gtg atg tcc atg cgc cgc tcc acg tac gtg ggt 1296 Met Asp Asn Thr Ser Val Met Ser Met Arg Arg Ser Thr Tyr Val Gly 420 425 430 gga acc gct ggc aat ctg cgg gcc tcg ctg cac cgg aac agc aat cac 1344 Gly Thr Ala Gly Asn Leu Arg Ala Ser Leu His Arg Asn Ser Asn His 435 440 445 gga gtt ggt gga gct gga ggt gga gta gga gga gga gta ggg tca ggt 1392 Gly Val Gly Gly Ala Gly Gly Gly Val Gly Gly Gly Val Gly Ser Gly 450 455 460 cgt gtg ggc agc ttt cat cgg cag gac tcg atg ccc ctg cag cac gga 1440 Arg Val Gly Ser Phe His Arg Gln Asp Ser Met Pro Leu Gln His Gly 465 470 475 480 aat gcc cac gga ggt ggt gcg ggc ggg gga tcc tcc gga ctt gga gcc 1488 Asn Ala His Gly Gly Gly Ala Gly Gly Gly Ser Ser Gly Leu Gly Ala 485 490 495 ggc ggg cgg acg gcg gca gtg agc gaa aag agn 1521 Gly Gly Arg Thr Ala Ala Val Ser Glu Lys 500 505 <210> SEQ ID NO 34 <211> LENGTH: 506 <212> TYPE: PRT <213> ORGANISM: Drosophila melanogaster <400> SEQUENCE: 34 Met Tyr Ala Ser Leu Met Asp Val Gly Gln Thr Leu Ala Ala Arg Leu 1 5 10 15 Ala Asp Ser Asp Gly Asn Gly Ala Asn Asp Ser Gly Leu Leu Ala Thr 20 25 30 Gly Gln Gly Leu Glu Gln Glu Gln Glu Gly Leu Ala Leu Asp Met Gly 35 40 45 His Asn Ala Ser Ala Asp Gly Gly Ile Val Pro Tyr Val Pro Val Leu 50 55 60 Asp Arg Pro Glu Thr Tyr Ile Val Thr Val Leu Tyr Thr Leu Ile Phe 65 70 75 80 Ile Val Gly Val Leu Gly Asn Gly Thr Leu Val Ile Ile Phe Phe Arg 85 90 95 His Arg Ser Met Arg Asn Ile Pro Asn Thr Tyr Ile Leu Ser Leu Ala 100 105 110 Leu Ala Asp Leu Leu Val Ile Leu Val Cys Val Pro Val Ala Thr Ile 115 120 125 Val Tyr Thr Gln Glu Ser Trp Pro Phe Glu Arg Asn Met Cys Arg Ile 130 135 140 Ser Glu Phe Phe Lys Asp Ile Ser Ile Gly Val Ser Val Phe Thr Leu 145 150 155 160 Thr Ala Leu Ser Gly Glu Arg Tyr Cys Ala Ile Val Asn Pro Leu Arg 165 170 175 Lys Leu Gln Thr Lys Pro Leu Thr Val Phe Thr Ala Val Met Ile Trp 180 185 190 Ile Leu Ala Ile Leu Leu Gly Met Pro Ser Val Leu Phe Ser Asp Ile 195 200 205 Lys Ser Tyr Pro Val Phe Thr Ala Thr Gly Asn Met Thr Ile Glu Val 210 215 220 Cys Ser Pro Phe Arg Asp Pro Glu Tyr Ala Lys Phe Met Val Ala Gly 225 230 235 240 Lys Ala Leu Val Tyr Tyr Leu Leu Pro Leu Ser Ile Ile Gly Ala Leu 245 250 255 Tyr Ile Met Met Ala Lys Arg Leu His Met Ser Ala Arg Asn Met Pro 260 265 270 Gly Glu Gln Gln Ser Met Gln Ser Arg Thr Gln Ala Arg Ala Arg Leu 275 280 285 His Val Ala Arg Met Val Val Ala Phe Val Val Val Phe Phe Ile Cys 290 295 300 Phe Phe Pro Tyr His Val Phe Glu Leu Trp Tyr His Phe Tyr Pro Thr 305 310 315 320 Ala Glu Glu Asp Phe Asp Glu Phe Trp Asn Val Leu Arg Ile Val Gly 325 330 335 Phe Cys Thr Ser Ala Val Lys Leu Lys Asn Asn Val Ser Ala Ile Trp 340 345 350 Trp Leu Asn Ser Leu Pro Leu Val Val Lys Ala Ile Cys Ile Leu Ala 355 360 365 Lys Trp Leu Pro Lys Leu Val Arg Gln Pro Arg Gly Leu Tyr Cys Val 370 375 380 Ser Gly Val Phe Arg Gln His Phe Asn Arg Tyr Leu Cys Cys Ile Cys 385 390 395 400 Val Lys Arg Gln Pro His Leu Arg Gln His Ser Thr Ala Thr Gly Met 405 410 415 Met Asp Asn Thr Ser Val Met Ser Met Arg Arg Ser Thr Tyr Val Gly 420 425 430 Gly Thr Ala Gly Asn Leu Arg Ala Ser Leu His Arg Asn Ser Asn His 435 440 445 Gly Val Gly Gly Ala Gly Gly Gly Val Gly Gly Gly Val Gly Ser Gly 450 455 460 Arg Val Gly Ser Phe His Arg Gln Asp Ser Met Pro Leu Gln His Gly 465 470 475 480 Asn Ala His Gly Gly Gly Ala Gly Gly Gly Ser Ser Gly Leu Gly Ala 485 490 495 Gly Gly Arg Thr Ala Ala Val Ser Glu Lys 500 505 <210> SEQ ID NO 35 <211> LENGTH: 1578 <212> TYPE: DNA <213> ORGANISM: Drosophila melanogaster <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(1575) <400> SEQUENCE: 35 atg acg tcc ttt att ggc ggc cca agg agt cgt cgc cac acg cac gaa 48 Met Thr Ser Phe Ile Gly Gly Pro Arg Ser Arg Arg His Thr His Glu 1 5 10 15 atg att atg acg atg atg cag acg gta agg gca tgg caa cag gaa tcg 96 Met Ile Met Thr Met Met Gln Thr Val Arg Ala Trp Gln Gln Glu Ser 20 25 30 gat gtg gag cac cga aaa caa cat aag cag cga tgg cga cct gat ggg 144 Asp Val Glu His Arg Lys Gln His Lys Gln Arg Trp Arg Pro Asp Gly 35 40 45 gca cac ata tca gcg gct tac gac ctc aac agt gat aat gac gac ggc 192 Ala His Ile Ser Ala Ala Tyr Asp Leu Asn Ser Asp Asn Asp Asp Gly 50 55 60 cac cac agg gtg gtg cat aat caa aac aac ggc agc cca aac agc tct 240 His His Arg Val Val His Asn Gln Asn Asn Gly Ser Pro Asn Ser Ser 65 70 75 80 ccg aat cag agc act tcc gcc ttc cga cag cgg caa ccg cac cac cca 288 Pro Asn Gln Ser Thr Ser Ala Phe Arg Gln Arg Gln Pro His His Pro 85 90 95 ccc acc gga caa caa ccg ccc cgg ctg ccc tgc acc gta acc cac ttc 336 Pro Thr Gly Gln Gln Pro Pro Arg Leu Pro Cys Thr Val Thr His Phe 100 105 110 tcc gca cac tgg aaa acg ctg ctc atc ctg ctc acc ctg ctc tcc gct 384 Ser Ala His Trp Lys Thr Leu Leu Ile Leu Leu Thr Leu Leu Ser Ala 115 120 125 tcc acg ctg aca gcc tcc gcc aat gtc acc agc acc atc agt ccg ccc 432 Ser Thr Leu Thr Ala Ser Ala Asn Val Thr Ser Thr Ile Ser Pro Pro 130 135 140 atc aac ggc agc agc acc gat tac atc ctg ctc tat ggc gaa tcc acc 480 Ile Asn Gly Ser Ser Thr Asp Tyr Ile Leu Leu Tyr Gly Glu Ser Thr 145 150 155 160 aca tcc ctt gtg ccc gcc ctg acc acc gga ctc tcg ggg gac gga agt 528 Thr Ser Leu Val Pro Ala Leu Thr Thr Gly Leu Ser Gly Asp Gly Ser 165 170 175 ggt gcg gtt atc gag gac gag gag gat gcc gag aag gcc agc gag tac 576 Gly Ala Val Ile Glu Asp Glu Glu Asp Ala Glu Lys Ala Ser Glu Tyr 180 185 190 atc ttt gat cgc acc gat gtg cgc ata ata ttc atc aca ctc tac aca 624 Ile Phe Asp Arg Thr Asp Val Arg Ile Ile Phe Ile Thr Leu Tyr Thr 195 200 205 ctg gtg ttt tgc tgc tgt ttc ttt ggt aac ctc ctt gtt att ttg gtg 672 Leu Val Phe Cys Cys Cys Phe Phe Gly Asn Leu Leu Val Ile Leu Val 210 215 220 gtc aca tta tca cga cga ctg cgc tca ata acc aac ttt ttc ctc gcc 720 Val Thr Leu Ser Arg Arg Leu Arg Ser Ile Thr Asn Phe Phe Leu Ala 225 230 235 240 aac ttg gcg ttt gcc gac ttc tgt gtt gga ctc ttt tgt gtg atg cag 768 Asn Leu Ala Phe Ala Asp Phe Cys Val Gly Leu Phe Cys Val Met Gln 245 250 255 aat ctg tcc atc tat ctg ata gaa agc tgg gtc ttt ggc gag ttc ctc 816 Asn Leu Ser Ile Tyr Leu Ile Glu Ser Trp Val Phe Gly Glu Phe Leu 260 265 270 tgc cgc atg tac cag ttt gtc cac tcc ctg agc tac acg gcc tcc att 864 Cys Arg Met Tyr Gln Phe Val His Ser Leu Ser Tyr Thr Ala Ser Ile 275 280 285 ttc atc ctg gtt gtc atc tgt atg gag cgc tac ttt gcc atc gta cac 912 Phe Ile Leu Val Val Ile Cys Met Glu Arg Tyr Phe Ala Ile Val His 290 295 300 ccc att acc tgc aaa cag atc cta act gcg gct cgt ctg agg atg gtc 960 Pro Ile Thr Cys Lys Gln Ile Leu Thr Ala Ala Arg Leu Arg Met Val 305 310 315 320 att gtc aca gtt tgg att aca tcg gca gtt tac tcc acg ccc aag ttt 1008 Ile Val Thr Val Trp Ile Thr Ser Ala Val Tyr Ser Thr Pro Lys Phe 325 330 335 gtt ttc agc aag acc att aag aac atc cac acg cag gac ggg cag gag 1056 Val Phe Ser Lys Thr Ile Lys Asn Ile His Thr Gln Asp Gly Gln Glu 340 345 350 gag gag ata tgt gtc ctg gac cgt gag atg ttc aac tcc aag ttg ctg 1104 Glu Glu Ile Cys Val Leu Asp Arg Glu Met Phe Asn Ser Lys Leu Leu 355 360 365 gac atg att aac ttt gtg ctt ctc tac gtt atg ccg ctc ttg gtg atg 1152 Asp Met Ile Asn Phe Val Leu Leu Tyr Val Met Pro Leu Leu Val Met 370 375 380 acg gtg ctg tac agc aaa atc gcc atc gcc ttg tgg cgc agt tcg cgc 1200 Thr Val Leu Tyr Ser Lys Ile Ala Ile Ala Leu Trp Arg Ser Ser Arg 385 390 395 400 ggc ctc acg ccg cat gtg gtg cag cat cag cat cag cag ccg cag cag 1248 Gly Leu Thr Pro His Val Val Gln His Gln His Gln Gln Pro Gln Gln 405 410 415 cca tcc tgc cag gac att ggc atg ggt atg cac aac agc atg tac cat 1296 Pro Ser Cys Gln Asp Ile Gly Met Gly Met His Asn Ser Met Tyr His 420 425 430 cac cat ccg cat cat cat cac cac cac cac cag cat cac cag ctg caa 1344 His His Pro His His His His His His His Gln His His Gln Leu Gln 435 440 445 tcg gcg gct tcg tcg gca gga gtg gtg gga gtg ggt ttg ggt ggt ggt 1392 Ser Ala Ala Ser Ser Ala Gly Val Val Gly Val Gly Leu Gly Gly Gly 450 455 460 ggt ggg ggc ggt cct ggt ccg tca ctc gct tcc ggc ggc agc agc acc 1440 Gly Gly Gly Gly Pro Gly Pro Ser Leu Ala Ser Gly Gly Ser Ser Thr 465 470 475 480 acg tcc ttg tcc cgc aaa cag agc agt aaa tat gag aag cgc ggc gtc 1488 Thr Ser Leu Ser Arg Lys Gln Ser Ser Lys Tyr Glu Lys Arg Gly Val 485 490 495 agc atc acg gag agc cag gtg agc tgc cag gag aac act gca tca gaa 1536 Ser Ile Thr Glu Ser Gln Val Ser Cys Gln Glu Asn Thr Ala Ser Glu 500 505 510 aaa tcg ccg gtt gag cac gga gga gta gcc tta aaa gcc taa 1578 Lys Ser Pro Val Glu His Gly Gly Val Ala Leu Lys Ala 515 520 525 <210> SEQ ID NO 36 <211> LENGTH: 525 <212> TYPE: PRT <213> ORGANISM: Drosophila melanogaster <400> SEQUENCE: 36 Met Thr Ser Phe Ile Gly Gly Pro Arg Ser Arg Arg His Thr His Glu 1 5 10 15 Met Ile Met Thr Met Met Gln Thr Val Arg Ala Trp Gln Gln Glu Ser 20 25 30 Asp Val Glu His Arg Lys Gln His Lys Gln Arg Trp Arg Pro Asp Gly 35 40 45 Ala His Ile Ser Ala Ala Tyr Asp Leu Asn Ser Asp Asn Asp Asp Gly 50 55 60 His His Arg Val Val His Asn Gln Asn Asn Gly Ser Pro Asn Ser Ser 65 70 75 80 Pro Asn Gln Ser Thr Ser Ala Phe Arg Gln Arg Gln Pro His His Pro 85 90 95 Pro Thr Gly Gln Gln Pro Pro Arg Leu Pro Cys Thr Val Thr His Phe 100 105 110 Ser Ala His Trp Lys Thr Leu Leu Ile Leu Leu Thr Leu Leu Ser Ala 115 120 125 Ser Thr Leu Thr Ala Ser Ala Asn Val Thr Ser Thr Ile Ser Pro Pro 130 135 140 Ile Asn Gly Ser Ser Thr Asp Tyr Ile Leu Leu Tyr Gly Glu Ser Thr 145 150 155 160 Thr Ser Leu Val Pro Ala Leu Thr Thr Gly Leu Ser Gly Asp Gly Ser 165 170 175 Gly Ala Val Ile Glu Asp Glu Glu Asp Ala Glu Lys Ala Ser Glu Tyr 180 185 190 Ile Phe Asp Arg Thr Asp Val Arg Ile Ile Phe Ile Thr Leu Tyr Thr 195 200 205 Leu Val Phe Cys Cys Cys Phe Phe Gly Asn Leu Leu Val Ile Leu Val 210 215 220 Val Thr Leu Ser Arg Arg Leu Arg Ser Ile Thr Asn Phe Phe Leu Ala 225 230 235 240 Asn Leu Ala Phe Ala Asp Phe Cys Val Gly Leu Phe Cys Val Met Gln 245 250 255 Asn Leu Ser Ile Tyr Leu Ile Glu Ser Trp Val Phe Gly Glu Phe Leu 260 265 270 Cys Arg Met Tyr Gln Phe Val His Ser Leu Ser Tyr Thr Ala Ser Ile 275 280 285 Phe Ile Leu Val Val Ile Cys Met Glu Arg Tyr Phe Ala Ile Val His 290 295 300 Pro Ile Thr Cys Lys Gln Ile Leu Thr Ala Ala Arg Leu Arg Met Val 305 310 315 320 Ile Val Thr Val Trp Ile Thr Ser Ala Val Tyr Ser Thr Pro Lys Phe 325 330 335 Val Phe Ser Lys Thr Ile Lys Asn Ile His Thr Gln Asp Gly Gln Glu 340 345 350 Glu Glu Ile Cys Val Leu Asp Arg Glu Met Phe Asn Ser Lys Leu Leu 355 360 365 Asp Met Ile Asn Phe Val Leu Leu Tyr Val Met Pro Leu Leu Val Met 370 375 380 Thr Val Leu Tyr Ser Lys Ile Ala Ile Ala Leu Trp Arg Ser Ser Arg 385 390 395 400 Gly Leu Thr Pro His Val Val Gln His Gln His Gln Gln Pro Gln Gln 405 410 415 Pro Ser Cys Gln Asp Ile Gly Met Gly Met His Asn Ser Met Tyr His 420 425 430 His His Pro His His His His His His His Gln His His Gln Leu Gln 435 440 445 Ser Ala Ala Ser Ser Ala Gly Val Val Gly Val Gly Leu Gly Gly Gly 450 455 460 Gly Gly Gly Gly Pro Gly Pro Ser Leu Ala Ser Gly Gly Ser Ser Thr 465 470 475 480 Thr Ser Leu Ser Arg Lys Gln Ser Ser Lys Tyr Glu Lys Arg Gly Val 485 490 495 Ser Ile Thr Glu Ser Gln Val Ser Cys Gln Glu Asn Thr Ala Ser Glu 500 505 510 Lys Ser Pro Val Glu His Gly Gly Val Ala Leu Lys Ala 515 520 525 <210> SEQ ID NO 37 <211> LENGTH: 1569 <212> TYPE: DNA <213> ORGANISM: Drosophila melanogaster <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(1566) <400> SEQUENCE: 37 atg aat cct ttg gtg ctg ggc cac cta ctg gca cca aac aaa ctt ttt 48 Met Asn Pro Leu Val Leu Gly His Leu Leu Ala Pro Asn Lys Leu Phe 1 5 10 15 ata cga tta ttg ccc cgt att tca agc cac aaa gca tta agc aag cca 96 Ile Arg Leu Leu Pro Arg Ile Ser Ser His Lys Ala Leu Ser Lys Pro 20 25 30 gtg gaa ttt gcc att cgc agc tcg cta gaa agt gtg ata atc agc atg 144 Val Glu Phe Ala Ile Arg Ser Ser Leu Glu Ser Val Ile Ile Ser Met 35 40 45 aat cag acg gag ccc gcc cag ctg gca gat ggg gag cat ctg agt gga 192 Asn Gln Thr Glu Pro Ala Gln Leu Ala Asp Gly Glu His Leu Ser Gly 50 55 60 tac gcc agc agc agc aac agc gtg cgc tat ctg gac gac cgg cat ccg 240 Tyr Ala Ser Ser Ser Asn Ser Val Arg Tyr Leu Asp Asp Arg His Pro 65 70 75 80 ctg gac tac ctt gac ctg ggc acg gtg cac gcc ctc aac acc act gcc 288 Leu Asp Tyr Leu Asp Leu Gly Thr Val His Ala Leu Asn Thr Thr Ala 85 90 95 atc aac acc tcg gat ctg aat gag act ggg agc agg ccg ctg gac ccg 336 Ile Asn Thr Ser Asp Leu Asn Glu Thr Gly Ser Arg Pro Leu Asp Pro 100 105 110 gtg ctt atc gat agg ttc ctg agc aac agg gcg gtg gac agc ccc tgg 384 Val Leu Ile Asp Arg Phe Leu Ser Asn Arg Ala Val Asp Ser Pro Trp 115 120 125 tac cac atg ctc atc agc atg tac ggc gtg cta atc gtc ttc ggc gcc 432 Tyr His Met Leu Ile Ser Met Tyr Gly Val Leu Ile Val Phe Gly Ala 130 135 140 cta ggc aac acc ctg gtt gtt ata gcc gtc atc cgg aag ccc atc atg 480 Leu Gly Asn Thr Leu Val Val Ile Ala Val Ile Arg Lys Pro Ile Met 145 150 155 160 cgc act gct cgc aat ctg ttc atc ctc aac ctg gcc ata tcg gtc acc 528 Arg Thr Ala Arg Asn Leu Phe Ile Leu Asn Leu Ala Ile Ser Val Thr 165 170 175 atg ccg ctg acc ttg atg gag atc ctg tcc aag tac tgg ccc tac ggc 576 Met Pro Leu Thr Leu Met Glu Ile Leu Ser Lys Tyr Trp Pro Tyr Gly 180 185 190 tcc tgc tcc atc ctg tgc aaa acg att gcc atg ctg cag gca ctt tgt 624 Ser Cys Ser Ile Leu Cys Lys Thr Ile Ala Met Leu Gln Ala Leu Cys 195 200 205 att ttc gtg tcg aca ata tcc ata acg gcc att gcc ttc gac aga tat 672 Ile Phe Val Ser Thr Ile Ser Ile Thr Ala Ile Ala Phe Asp Arg Tyr 210 215 220 cag gtg atc gtg tac ccc acg cgg gac agc ctg cag ttc gtg ggc gcg 720 Gln Val Ile Val Tyr Pro Thr Arg Asp Ser Leu Gln Phe Val Gly Ala 225 230 235 240 gtg acg atc ctg gcg ggg atc tgg gca ctg gca ctg ctg ctg gcc tcg 768 Val Thr Ile Leu Ala Gly Ile Trp Ala Leu Ala Leu Leu Leu Ala Ser 245 250 255 ccg ctg ttc gtc tac aag gag ctg atc aac aca gac acg ccg gca ctc 816 Pro Leu Phe Val Tyr Lys Glu Leu Ile Asn Thr Asp Thr Pro Ala Leu 260 265 270 ctg cag cag atc ggc ctg cag gac acg atc ccg tac tgc att gag gac 864 Leu Gln Gln Ile Gly Leu Gln Asp Thr Ile Pro Tyr Cys Ile Glu Asp 275 280 285 tgg cca agt cgc aac ggg cgc ttc tac tac tcg atc ttc tcg ctg tgc 912 Trp Pro Ser Arg Asn Gly Arg Phe Tyr Tyr Ser Ile Phe Ser Leu Cys 290 295 300 gta caa tac ctg gtg ccc atc ctg atc gtc tcg gtg gca tac ttc ggg 960 Val Gln Tyr Leu Val Pro Ile Leu Ile Val Ser Val Ala Tyr Phe Gly 305 310 315 320 atc tac aac aag ctg aag agc cgc atc acc gtg gtg gct gtg cag gcg 1008 Ile Tyr Asn Lys Leu Lys Ser Arg Ile Thr Val Val Ala Val Gln Ala 325 330 335 tcc tcc gct cag cgg aag gtg gag cgg ggg cgg cgg atg aag cgc acc 1056 Ser Ser Ala Gln Arg Lys Val Glu Arg Gly Arg Arg Met Lys Arg Thr 340 345 350 aac tgc cta ctg atc agc atc gcc atc atc ttt ggc gtt tct tgg ctg 1104 Asn Cys Leu Leu Ile Ser Ile Ala Ile Ile Phe Gly Val Ser Trp Leu 355 360 365 ccg ctg aac ttt ttc aac ctg tac gcg gac atg gag cgc tcg ccg gtc 1152 Pro Leu Asn Phe Phe Asn Leu Tyr Ala Asp Met Glu Arg Ser Pro Val 370 375 380 act cag agc atg cta gtc cgc tac gcc atc tgc cac atg atc ggc atg 1200 Thr Gln Ser Met Leu Val Arg Tyr Ala Ile Cys His Met Ile Gly Met 385 390 395 400 agc tcc gcc tgc tcc aac ccg ttg ctc tac ggc tgg ctc aac gac aac 1248 Ser Ser Ala Cys Ser Asn Pro Leu Leu Tyr Gly Trp Leu Asn Asp Asn 405 410 415 ttc cgt aaa gaa ttt caa gaa ctg ctc tgc cgt tgc tca gac act aat 1296 Phe Arg Lys Glu Phe Gln Glu Leu Leu Cys Arg Cys Ser Asp Thr Asn 420 425 430 gtt gct ctt aac ggt cac acg aca ggc tgc aac gtc cag gcg gcg gcg 1344 Val Ala Leu Asn Gly His Thr Thr Gly Cys Asn Val Gln Ala Ala Ala 435 440 445 cgc agg cgt cgc aag ttg ggc gcc gaa ctc tcc aaa ggc gaa ctc aag 1392 Arg Arg Arg Arg Lys Leu Gly Ala Glu Leu Ser Lys Gly Glu Leu Lys 450 455 460 ctg ctg ggg cca ggc ggc gcc cag agc ggt acc gcc ggc ggg gaa ggc 1440 Leu Leu Gly Pro Gly Gly Ala Gln Ser Gly Thr Ala Gly Gly Glu Gly 465 470 475 480 ggt ctg gcg gcc acc gac ttc atg acc ggc cac cac gag ggc gga ctg 1488 Gly Leu Ala Ala Thr Asp Phe Met Thr Gly His His Glu Gly Gly Leu 485 490 495 cgc agc gcc ata acc gag tcg gtg gcc ctc acg gac cac aac ccc gtg 1536 Arg Ser Ala Ile Thr Glu Ser Val Ala Leu Thr Asp His Asn Pro Val 500 505 510 ccc tcg gag gtc acc aag ctg atg ccg cgg taa 1569 Pro Ser Glu Val Thr Lys Leu Met Pro Arg 515 520 <210> SEQ ID NO 38 <211> LENGTH: 522 <212> TYPE: PRT <213> ORGANISM: Drosophila melanogaster <400> SEQUENCE: 38 Met Asn Pro Leu Val Leu Gly His Leu Leu Ala Pro Asn Lys Leu Phe 1 5 10 15 Ile Arg Leu Leu Pro Arg Ile Ser Ser His Lys Ala Leu Ser Lys Pro 20 25 30 Val Glu Phe Ala Ile Arg Ser Ser Leu Glu Ser Val Ile Ile Ser Met 35 40 45 Asn Gln Thr Glu Pro Ala Gln Leu Ala Asp Gly Glu His Leu Ser Gly 50 55 60 Tyr Ala Ser Ser Ser Asn Ser Val Arg Tyr Leu Asp Asp Arg His Pro 65 70 75 80 Leu Asp Tyr Leu Asp Leu Gly Thr Val His Ala Leu Asn Thr Thr Ala 85 90 95 Ile Asn Thr Ser Asp Leu Asn Glu Thr Gly Ser Arg Pro Leu Asp Pro 100 105 110 Val Leu Ile Asp Arg Phe Leu Ser Asn Arg Ala Val Asp Ser Pro Trp 115 120 125 Tyr His Met Leu Ile Ser Met Tyr Gly Val Leu Ile Val Phe Gly Ala 130 135 140 Leu Gly Asn Thr Leu Val Val Ile Ala Val Ile Arg Lys Pro Ile Met 145 150 155 160 Arg Thr Ala Arg Asn Leu Phe Ile Leu Asn Leu Ala Ile Ser Val Thr 165 170 175 Met Pro Leu Thr Leu Met Glu Ile Leu Ser Lys Tyr Trp Pro Tyr Gly 180 185 190 Ser Cys Ser Ile Leu Cys Lys Thr Ile Ala Met Leu Gln Ala Leu Cys 195 200 205 Ile Phe Val Ser Thr Ile Ser Ile Thr Ala Ile Ala Phe Asp Arg Tyr 210 215 220 Gln Val Ile Val Tyr Pro Thr Arg Asp Ser Leu Gln Phe Val Gly Ala 225 230 235 240 Val Thr Ile Leu Ala Gly Ile Trp Ala Leu Ala Leu Leu Leu Ala Ser 245 250 255 Pro Leu Phe Val Tyr Lys Glu Leu Ile Asn Thr Asp Thr Pro Ala Leu 260 265 270 Leu Gln Gln Ile Gly Leu Gln Asp Thr Ile Pro Tyr Cys Ile Glu Asp 275 280 285 Trp Pro Ser Arg Asn Gly Arg Phe Tyr Tyr Ser Ile Phe Ser Leu Cys 290 295 300 Val Gln Tyr Leu Val Pro Ile Leu Ile Val Ser Val Ala Tyr Phe Gly 305 310 315 320 Ile Tyr Asn Lys Leu Lys Ser Arg Ile Thr Val Val Ala Val Gln Ala 325 330 335 Ser Ser Ala Gln Arg Lys Val Glu Arg Gly Arg Arg Met Lys Arg Thr 340 345 350 Asn Cys Leu Leu Ile Ser Ile Ala Ile Ile Phe Gly Val Ser Trp Leu 355 360 365 Pro Leu Asn Phe Phe Asn Leu Tyr Ala Asp Met Glu Arg Ser Pro Val 370 375 380 Thr Gln Ser Met Leu Val Arg Tyr Ala Ile Cys His Met Ile Gly Met 385 390 395 400 Ser Ser Ala Cys Ser Asn Pro Leu Leu Tyr Gly Trp Leu Asn Asp Asn 405 410 415 Phe Arg Lys Glu Phe Gln Glu Leu Leu Cys Arg Cys Ser Asp Thr Asn 420 425 430 Val Ala Leu Asn Gly His Thr Thr Gly Cys Asn Val Gln Ala Ala Ala 435 440 445 Arg Arg Arg Arg Lys Leu Gly Ala Glu Leu Ser Lys Gly Glu Leu Lys 450 455 460 Leu Leu Gly Pro Gly Gly Ala Gln Ser Gly Thr Ala Gly Gly Glu Gly 465 470 475 480 Gly Leu Ala Ala Thr Asp Phe Met Thr Gly His His Glu Gly Gly Leu 485 490 495 Arg Ser Ala Ile Thr Glu Ser Val Ala Leu Thr Asp His Asn Pro Val 500 505 510 Pro Ser Glu Val Thr Lys Leu Met Pro Arg 515 520 <210> SEQ ID NO 39 <211> LENGTH: 540 <212> TYPE: DNA <213> ORGANISM: Drosophila melanogaster <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(537) <400> SEQUENCE: 39 atg gag aac acc aca atg ctg gct aat att agc cta aat gca acc aga 48 Met Glu Asn Thr Thr Met Leu Ala Asn Ile Ser Leu Asn Ala Thr Arg 1 5 10 15 aat gag gag aat atc acc tca ttc ttc acc gac gaa gag tgg ctg gcc 96 Asn Glu Glu Asn Ile Thr Ser Phe Phe Thr Asp Glu Glu Trp Leu Ala 20 25 30 atc aat ggc act ttg ccg tgg ata gtg gga ttc ttc ttc ggc gtc atc 144 Ile Asn Gly Thr Leu Pro Trp Ile Val Gly Phe Phe Phe Gly Val Ile 35 40 45 gcc atc acg gga ttc ttc ggc aac ctg ctg gtc atc ctg gtg gtg gtc 192 Ala Ile Thr Gly Phe Phe Gly Asn Leu Leu Val Ile Leu Val Val Val 50 55 60 ttc aac aac aac atg cgc tcc acc acc aac ctg atg att gtc aat ctg 240 Phe Asn Asn Asn Met Arg Ser Thr Thr Asn Leu Met Ile Val Asn Leu 65 70 75 80 gct gcc gct gat ctg atg ttc gta atc ctc tgc att ccc ttc acg gcc 288 Ala Ala Ala Asp Leu Met Phe Val Ile Leu Cys Ile Pro Phe Thr Ala 85 90 95 acc gat tac atg gtg tac tac tgg cca tat gga agg ttc tgg tgc cgc 336 Thr Asp Tyr Met Val Tyr Tyr Trp Pro Tyr Gly Arg Phe Trp Cys Arg 100 105 110 agt gtc cag tac ctg att gtg gtg acc gcc ttc gcc tcc att tac acg 384 Ser Val Gln Tyr Leu Ile Val Val Thr Ala Phe Ala Ser Ile Tyr Thr 115 120 125 ctg gtg ctg atg tcc atc gat cgg ttc ctg gcg gtg gtt cat ccc att 432 Leu Val Leu Met Ser Ile Asp Arg Phe Leu Ala Val Val His Pro Ile 130 135 140 cgc tcg cgg atg atg agg acg gag aac att acc ctg att gcc atc gtg 480 Arg Ser Arg Met Met Arg Thr Glu Asn Ile Thr Leu Ile Ala Ile Val 145 150 155 160 act ctg tgg atc gtg gtg ctg gtc gtt tcg gtg cca gtg gcc ttc acc 528 Thr Leu Trp Ile Val Val Leu Val Val Ser Val Pro Val Ala Phe Thr 165 170 175 cac gac gtg gtg 540 His Asp Val <210> SEQ ID NO 40 <211> LENGTH: 179 <212> TYPE: PRT <213> ORGANISM: Drosophila melanogaster <400> SEQUENCE: 40 Met Glu Asn Thr Thr Met Leu Ala Asn Ile Ser Leu Asn Ala Thr Arg 1 5 10 15 Asn Glu Glu Asn Ile Thr Ser Phe Phe Thr Asp Glu Glu Trp Leu Ala 20 25 30 Ile Asn Gly Thr Leu Pro Trp Ile Val Gly Phe Phe Phe Gly Val Ile 35 40 45 Ala Ile Thr Gly Phe Phe Gly Asn Leu Leu Val Ile Leu Val Val Val 50 55 60 Phe Asn Asn Asn Met Arg Ser Thr Thr Asn Leu Met Ile Val Asn Leu 65 70 75 80 Ala Ala Ala Asp Leu Met Phe Val Ile Leu Cys Ile Pro Phe Thr Ala 85 90 95 Thr Asp Tyr Met Val Tyr Tyr Trp Pro Tyr Gly Arg Phe Trp Cys Arg 100 105 110 Ser Val Gln Tyr Leu Ile Val Val Thr Ala Phe Ala Ser Ile Tyr Thr 115 120 125 Leu Val Leu Met Ser Ile Asp Arg Phe Leu Ala Val Val His Pro Ile 130 135 140 Arg Ser Arg Met Met Arg Thr Glu Asn Ile Thr Leu Ile Ala Ile Val 145 150 155 160 Thr Leu Trp Ile Val Val Leu Val Val Ser Val Pro Val Ala Phe Thr 165 170 175 His Asp Val <210> SEQ ID NO 41 <211> LENGTH: 624 <212> TYPE: DNA <213> ORGANISM: Drosophila melanogaster <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(621) <400> SEQUENCE: 41 atg acg tat gcg caa tat tcg att ccc aca ccg cac acg ttt ctt cat 48 Met Thr Tyr Ala Gln Tyr Ser Ile Pro Thr Pro His Thr Phe Leu His 1 5 10 15 agt tcc cac aac cac att ctc atc gat atc cgc agg tgg att acg atg 96 Ser Ser His Asn His Ile Leu Ile Asp Ile Arg Arg Trp Ile Thr Met 20 25 30 caa aga aga aca tca cct acg gca tgt gca cct tca cga cga acg act 144 Gln Arg Arg Thr Ser Pro Thr Ala Cys Ala Pro Ser Arg Arg Thr Thr 35 40 45 tcc ttg gtc acc ttc ttc atc agc tcc tac ctg ctg ccc ctg atg atc 192 Ser Leu Val Thr Phe Phe Ile Ser Ser Tyr Leu Leu Pro Leu Met Ile 50 55 60 atc agc ggt ctc tac atg cgc atg atc atg cgg ctc tgg cgc cag gga 240 Ile Ser Gly Leu Tyr Met Arg Met Ile Met Arg Leu Trp Arg Gln Gly 65 70 75 80 acc ggc gtc cgc atg tcc aag gag tcg cag cgc ggt cgc aag cgg gtc 288 Thr Gly Val Arg Met Ser Lys Glu Ser Gln Arg Gly Arg Lys Arg Val 85 90 95 acc cga ctc gtc gtc gtg gtg gtc atc gcc ttc gcc tcg ctc tgg ctg 336 Thr Arg Leu Val Val Val Val Val Ile Ala Phe Ala Ser Leu Trp Leu 100 105 110 cct gtc cag ctc atc ctg ctg ctc aag tca ctg gat gtc atc gag acg 384 Pro Val Gln Leu Ile Leu Leu Leu Lys Ser Leu Asp Val Ile Glu Thr 115 120 125 aac acc ctc acc aag cta gtc atc cag gtc acc gcc cag act ctg gcc 432 Asn Thr Leu Thr Lys Leu Val Ile Gln Val Thr Ala Gln Thr Leu Ala 130 135 140 tac agc agc tcg tgt atc aat ccg ctg ctc tac gcc ttc ctc tcc gag 480 Tyr Ser Ser Ser Cys Ile Asn Pro Leu Leu Tyr Ala Phe Leu Ser Glu 145 150 155 160 aat ttc cgg aag gcc ttc tac aag aca atg cga atg cac agc gca cct 528 Asn Phe Arg Lys Ala Phe Tyr Lys Thr Met Arg Met His Ser Ala Pro 165 170 175 gga aag cca agg acc gca act gcc ggc ggt tca aaa ccc gta att cat 576 Gly Lys Pro Arg Thr Ala Thr Ala Gly Gly Ser Lys Pro Val Ile His 180 185 190 ttc ccc gga gcc ctg tgc tgt gtt gct gtc tct gtg acg agg cac taa 624 Phe Pro Gly Ala Leu Cys Cys Val Ala Val Ser Val Thr Arg His 195 200 205 <210> SEQ ID NO 42 <211> LENGTH: 207 <212> TYPE: PRT <213> ORGANISM: Drosophila melanogaster <400> SEQUENCE: 42 Met Thr Tyr Ala Gln Tyr Ser Ile Pro Thr Pro His Thr Phe Leu His 1 5 10 15 Ser Ser His Asn His Ile Leu Ile Asp Ile Arg Arg Trp Ile Thr Met 20 25 30 Gln Arg Arg Thr Ser Pro Thr Ala Cys Ala Pro Ser Arg Arg Thr Thr 35 40 45 Ser Leu Val Thr Phe Phe Ile Ser Ser Tyr Leu Leu Pro Leu Met Ile 50 55 60 Ile Ser Gly Leu Tyr Met Arg Met Ile Met Arg Leu Trp Arg Gln Gly 65 70 75 80 Thr Gly Val Arg Met Ser Lys Glu Ser Gln Arg Gly Arg Lys Arg Val 85 90 95 Thr Arg Leu Val Val Val Val Val Ile Ala Phe Ala Ser Leu Trp Leu 100 105 110 Pro Val Gln Leu Ile Leu Leu Leu Lys Ser Leu Asp Val Ile Glu Thr 115 120 125 Asn Thr Leu Thr Lys Leu Val Ile Gln Val Thr Ala Gln Thr Leu Ala 130 135 140 Tyr Ser Ser Ser Cys Ile Asn Pro Leu Leu Tyr Ala Phe Leu Ser Glu 145 150 155 160 Asn Phe Arg Lys Ala Phe Tyr Lys Thr Met Arg Met His Ser Ala Pro 165 170 175 Gly Lys Pro Arg Thr Ala Thr Ala Gly Gly Ser Lys Pro Val Ile His 180 185 190 Phe Pro Gly Ala Leu Cys Cys Val Ala Val Ser Val Thr Arg His 195 200 205 <210> SEQ ID NO 43 <211> LENGTH: 1566 <212> TYPE: DNA <213> ORGANISM: Drosophila melanogaster <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(1563) <400> SEQUENCE: 43 atg gcc ctg ctc cac tac acc ttc gac cag ctc gag ttg tac cta gaa 48 Met Ala Leu Leu His Tyr Thr Phe Asp Gln Leu Glu Leu Tyr Leu Glu 1 5 10 15 tgg gcg ttc gcc cag cac gga gag gcc acg ccg att ccc tcg atc cag 96 Trp Ala Phe Ala Gln His Gly Glu Ala Thr Pro Ile Pro Ser Ile Gln 20 25 30 ccg tat ccg ggc gtg ttc gtg ggc gat ctc agc cag ctg aac cgc ttc 144 Pro Tyr Pro Gly Val Phe Val Gly Asp Leu Ser Gln Leu Asn Arg Phe 35 40 45 aag cga cat gcc ttc tcc gcc gtc gtg ggc acg ctc ttc gtc ctc gcc 192 Lys Arg His Ala Phe Ser Ala Val Val Gly Thr Leu Phe Val Leu Ala 50 55 60 ttc tgc ggc aac ctg agc acc ctc tat gtg aac agc cgc cgg aag ctg 240 Phe Cys Gly Asn Leu Ser Thr Leu Tyr Val Asn Ser Arg Arg Lys Leu 65 70 75 80 cgg ccc ttc ttc cgg gcc tgc ctc atc tca ctg gcc tgc agt gac ctt 288 Arg Pro Phe Phe Arg Ala Cys Leu Ile Ser Leu Ala Cys Ser Asp Leu 85 90 95 gtc tcc agc ata ttc tgc acc gta tcc tac atg gcc cag ttc cag gcg 336 Val Ser Ser Ile Phe Cys Thr Val Ser Tyr Met Ala Gln Phe Gln Ala 100 105 110 cag tat ctg cag ctc tgg aca att ggt ggc ttc atg tgc aag ttt gtg 384 Gln Tyr Leu Gln Leu Trp Thr Ile Gly Gly Phe Met Cys Lys Phe Val 115 120 125 ccg ttc ata acc acc acg tcg gtg ttg tcc ggc agc ctg acc ctg gtg 432 Pro Phe Ile Thr Thr Thr Ser Val Leu Ser Gly Ser Leu Thr Leu Val 130 135 140 gcc atc gcc ttg gac cgc tac ttg gcc gtg atg cga ccc gtg ctg ggg 480 Ala Ile Ala Leu Asp Arg Tyr Leu Ala Val Met Arg Pro Val Leu Gly 145 150 155 160 ttc tgg agt ccc gac aaa cgc ttc agc act ctg agc atg ctg ctc atc 528 Phe Trp Ser Pro Asp Lys Arg Phe Ser Thr Leu Ser Met Leu Leu Ile 165 170 175 tgg gca tgt tcg ata gga tcc tct ggc ccg ctg ctg ggc atc tac gac 576 Trp Ala Cys Ser Ile Gly Ser Ser Gly Pro Leu Leu Gly Ile Tyr Asp 180 185 190 tac cga aag atc tat ctc ctg gat gtg gag gac tcc agc gag gag agc 624 Tyr Arg Lys Ile Tyr Leu Leu Asp Val Glu Asp Ser Ser Glu Glu Ser 195 200 205 gag gag gtc gtg acc gct gtg ccc gag gag ctg gtg gtc acc gag ctg 672 Glu Glu Val Val Thr Ala Val Pro Glu Glu Leu Val Val Thr Glu Leu 210 215 220 gaa atg gtt cac atg tgc ctg gcc ggg gac cac gac gtc gga ctc tac 720 Glu Met Val His Met Cys Leu Ala Gly Asp His Asp Val Gly Leu Tyr 225 230 235 240 tac gtc ata ctg ttc acc ctg atc ttc ctg ccg tgc att gtg tcc ttc 768 Tyr Val Ile Leu Phe Thr Leu Ile Phe Leu Pro Cys Ile Val Ser Phe 245 250 255 cta tgg ctg aat gcc gtg att gcg agg cag ctc tgg ctg cgg aga cac 816 Leu Trp Leu Asn Ala Val Ile Ala Arg Gln Leu Trp Leu Arg Arg His 260 265 270 tac cac cag gag cag cag gag cag cat cag gag ccc aag gag ggt cag 864 Tyr His Gln Glu Gln Gln Glu Gln His Gln Glu Pro Lys Glu Gly Gln 275 280 285 ttt aag acc atg gcg aat ggc ggg gat ctc ttg atg ccc tcc acc ttg 912 Phe Lys Thr Met Ala Asn Gly Gly Asp Leu Leu Met Pro Ser Thr Leu 290 295 300 gtc agt gcc atg gga gtg gcc gtt ccc ttt gcg ctg gac aac act ccc 960 Val Ser Ala Met Gly Val Ala Val Pro Phe Ala Leu Asp Asn Thr Pro 305 310 315 320 ttg ccg ccc aag agt acc gtc aac gct cct ggc aag aag acc act gct 1008 Leu Pro Pro Lys Ser Thr Val Asn Ala Pro Gly Lys Lys Thr Thr Ala 325 330 335 gct gct cta gcc agg gag gcc agg cac cgc aag atg gtg gtg gtg gtg 1056 Ala Ala Leu Ala Arg Glu Ala Arg His Arg Lys Met Val Val Val Val 340 345 350 ctg cta atg atg gcg gtt ttc ata tgc ctt cga ctg ccc gcc tgg gtc 1104 Leu Leu Met Met Ala Val Phe Ile Cys Leu Arg Leu Pro Ala Trp Val 355 360 365 ttc ctg atc atg cgg ctt tat gga tcc tac tcc gag ccc atc gac tgg 1152 Phe Leu Ile Met Arg Leu Tyr Gly Ser Tyr Ser Glu Pro Ile Asp Trp 370 375 380 ctc ctg tac ttc agc ttc ggc ata ctg aac ctt ttc agt tgc gcc cta 1200 Leu Leu Tyr Phe Ser Phe Gly Ile Leu Asn Leu Phe Ser Cys Ala Leu 385 390 395 400 aat ccc atc ttc tac acc ttc ctc acc cag acc att agg acc ttg acg 1248 Asn Pro Ile Phe Tyr Thr Phe Leu Thr Gln Thr Ile Arg Thr Leu Thr 405 410 415 ctg gtg aaa cac aaa att cag gga ttt ctt ggc tgt ccg cct ggt aaa 1296 Leu Val Lys His Lys Ile Gln Gly Phe Leu Gly Cys Pro Pro Gly Lys 420 425 430 gtg ccg gat ggt atg ccc acg gat cag atg gac aaa agc ggg tgc tgc 1344 Val Pro Asp Gly Met Pro Thr Asp Gln Met Asp Lys Ser Gly Cys Cys 435 440 445 tgc ggc ctg agg cca ccc acc ttc aca tgg agg tgc cat ccc agc cgc 1392 Cys Gly Leu Arg Pro Pro Thr Phe Thr Trp Arg Cys His Pro Ser Arg 450 455 460 gat agg gca gca gcc acc gta atc cgg gat gtg gac cag cca gat ccg 1440 Asp Arg Ala Ala Ala Thr Val Ile Arg Asp Val Asp Gln Pro Asp Pro 465 470 475 480 ccc tcc gac cag gtg caa ccg gat ccg agt agc cta cgg cgg ttc ctc 1488 Pro Ser Asp Gln Val Gln Pro Asp Pro Ser Ser Leu Arg Arg Phe Leu 485 490 495 agc tac aag cag gag gtg ttc acc att tac aag cag tgc ggt gac tcg 1536 Ser Tyr Lys Gln Glu Val Phe Thr Ile Tyr Lys Gln Cys Gly Asp Ser 500 505 510 tcg agt gcg tca atc gag tcc tcc gcc tga 1566 Ser Ser Ala Ser Ile Glu Ser Ser Ala 515 520 <210> SEQ ID NO 44 <211> LENGTH: 521 <212> TYPE: PRT <213> ORGANISM: Drosophila melanogaster <400> SEQUENCE: 44 Met Ala Leu Leu His Tyr Thr Phe Asp Gln Leu Glu Leu Tyr Leu Glu 1 5 10 15 Trp Ala Phe Ala Gln His Gly Glu Ala Thr Pro Ile Pro Ser Ile Gln 20 25 30 Pro Tyr Pro Gly Val Phe Val Gly Asp Leu Ser Gln Leu Asn Arg Phe 35 40 45 Lys Arg His Ala Phe Ser Ala Val Val Gly Thr Leu Phe Val Leu Ala 50 55 60 Phe Cys Gly Asn Leu Ser Thr Leu Tyr Val Asn Ser Arg Arg Lys Leu 65 70 75 80 Arg Pro Phe Phe Arg Ala Cys Leu Ile Ser Leu Ala Cys Ser Asp Leu 85 90 95 Val Ser Ser Ile Phe Cys Thr Val Ser Tyr Met Ala Gln Phe Gln Ala 100 105 110 Gln Tyr Leu Gln Leu Trp Thr Ile Gly Gly Phe Met Cys Lys Phe Val 115 120 125 Pro Phe Ile Thr Thr Thr Ser Val Leu Ser Gly Ser Leu Thr Leu Val 130 135 140 Ala Ile Ala Leu Asp Arg Tyr Leu Ala Val Met Arg Pro Val Leu Gly 145 150 155 160 Phe Trp Ser Pro Asp Lys Arg Phe Ser Thr Leu Ser Met Leu Leu Ile 165 170 175 Trp Ala Cys Ser Ile Gly Ser Ser Gly Pro Leu Leu Gly Ile Tyr Asp 180 185 190 Tyr Arg Lys Ile Tyr Leu Leu Asp Val Glu Asp Ser Ser Glu Glu Ser 195 200 205 Glu Glu Val Val Thr Ala Val Pro Glu Glu Leu Val Val Thr Glu Leu 210 215 220 Glu Met Val His Met Cys Leu Ala Gly Asp His Asp Val Gly Leu Tyr 225 230 235 240 Tyr Val Ile Leu Phe Thr Leu Ile Phe Leu Pro Cys Ile Val Ser Phe 245 250 255 Leu Trp Leu Asn Ala Val Ile Ala Arg Gln Leu Trp Leu Arg Arg His 260 265 270 Tyr His Gln Glu Gln Gln Glu Gln His Gln Glu Pro Lys Glu Gly Gln 275 280 285 Phe Lys Thr Met Ala Asn Gly Gly Asp Leu Leu Met Pro Ser Thr Leu 290 295 300 Val Ser Ala Met Gly Val Ala Val Pro Phe Ala Leu Asp Asn Thr Pro 305 310 315 320 Leu Pro Pro Lys Ser Thr Val Asn Ala Pro Gly Lys Lys Thr Thr Ala 325 330 335 Ala Ala Leu Ala Arg Glu Ala Arg His Arg Lys Met Val Val Val Val 340 345 350 Leu Leu Met Met Ala Val Phe Ile Cys Leu Arg Leu Pro Ala Trp Val 355 360 365 Phe Leu Ile Met Arg Leu Tyr Gly Ser Tyr Ser Glu Pro Ile Asp Trp 370 375 380 Leu Leu Tyr Phe Ser Phe Gly Ile Leu Asn Leu Phe Ser Cys Ala Leu 385 390 395 400 Asn Pro Ile Phe Tyr Thr Phe Leu Thr Gln Thr Ile Arg Thr Leu Thr 405 410 415 Leu Val Lys His Lys Ile Gln Gly Phe Leu Gly Cys Pro Pro Gly Lys 420 425 430 Val Pro Asp Gly Met Pro Thr Asp Gln Met Asp Lys Ser Gly Cys Cys 435 440 445 Cys Gly Leu Arg Pro Pro Thr Phe Thr Trp Arg Cys His Pro Ser Arg 450 455 460 Asp Arg Ala Ala Ala Thr Val Ile Arg Asp Val Asp Gln Pro Asp Pro 465 470 475 480 Pro Ser Asp Gln Val Gln Pro Asp Pro Ser Ser Leu Arg Arg Phe Leu 485 490 495 Ser Tyr Lys Gln Glu Val Phe Thr Ile Tyr Lys Gln Cys Gly Asp Ser 500 505 510 Ser Ser Ala Ser Ile Glu Ser Ser Ala 515 520 <210> SEQ ID NO 45 <211> LENGTH: 816 <212> TYPE: DNA <213> ORGANISM: Drosophila melanogaster <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (1)..(813) <400> SEQUENCE: 45 atg gag gac gag tgg ggc tcc ttt gat cgt ctg ccc agt gtt ccg agt 48 Met Glu Asp Glu Trp Gly Ser Phe Asp Arg Leu Pro Ser Val Pro Ser 1 5 10 15 gcc tcg atg gat ttg gag acg gaa aac gag gtg gtc agc aat tgg tcc 96 Ala Ser Met Asp Leu Glu Thr Glu Asn Glu Val Val Ser Asn Trp Ser 20 25 30 aca ctg gcc aac ttc acg cga ctt gtg gct ggt gcc gct cct gaa atc 144 Thr Leu Ala Asn Phe Thr Arg Leu Val Ala Gly Ala Ala Pro Glu Ile 35 40 45 gtc aac tat acg ctc aac atg atc gac gtg ggt gtg ggc atg gcc acg 192 Val Asn Tyr Thr Leu Asn Met Ile Asp Val Gly Val Gly Met Ala Thr 50 55 60 gat ata tcc aat ttg agc gtt ccg gag cac gtg atg gat cac gca cct 240 Asp Ile Ser Asn Leu Ser Val Pro Glu His Val Met Asp His Ala Pro 65 70 75 80 caa cta tcc cga tcc ggg ttg ctg aaa gtg tat gtc ctg gcg gta atg 288 Gln Leu Ser Arg Ser Gly Leu Leu Lys Val Tyr Val Leu Ala Val Met 85 90 95 gca ctg ttc tct ctg ctg ggc aac ctg ctg acc atc tgg aat atc tac 336 Ala Leu Phe Ser Leu Leu Gly Asn Leu Leu Thr Ile Trp Asn Ile Tyr 100 105 110 aaa acc cgc atc tca aga aga aac tca cgg cac acg tgg agt gct atc 384 Lys Thr Arg Ile Ser Arg Arg Asn Ser Arg His Thr Trp Ser Ala Ile 115 120 125 tac tca ctg atg ttc cat ctg tcc atc gcc gat gtc ctg gtc acc tgg 432 Tyr Ser Leu Met Phe His Leu Ser Ile Ala Asp Val Leu Val Thr Trp 130 135 140 ttc tgc att atc ggg gag gcc gcg tgg tgc tac acc gtc cag tgg ctg 480 Phe Cys Ile Ile Gly Glu Ala Ala Trp Cys Tyr Thr Val Gln Trp Leu 145 150 155 160 gcc aat gag ctc acc tgc aag ctg gtg aag ctc ttc cag atg ttt agc 528 Ala Asn Glu Leu Thr Cys Lys Leu Val Lys Leu Phe Gln Met Phe Ser 165 170 175 ctc tac ctg agc acc tat gtc ctg gtc ctc atc gga gtg gac cgc tgg 576 Leu Tyr Leu Ser Thr Tyr Val Leu Val Leu Ile Gly Val Asp Arg Trp 180 185 190 ata gcg gtc aag tat ccg atg aag tcg ctc aac atg gcc aag agg tgt 624 Ile Ala Val Lys Tyr Pro Met Lys Ser Leu Asn Met Ala Lys Arg Cys 195 200 205 cat agg cta ctt ggc ggt act tac atc ctg tcg ctg gtg ctc agc ttg 672 His Arg Leu Leu Gly Gly Thr Tyr Ile Leu Ser Leu Val Leu Ser Leu 210 215 220 cca cag ata ggc aca ctg ggt gat ata ttc ctt tgc cct ggc agt cag 720 Pro Gln Ile Gly Thr Leu Gly Asp Ile Phe Leu Cys Pro Gly Ser Gln 225 230 235 240 ctg gcg gat aag cct gaa tgg gac tgc att aat ggg cgt cac tcg ctt 768 Leu Ala Asp Lys Pro Glu Trp Asp Cys Ile Asn Gly Arg His Ser Leu 245 250 255 tgt tct aca act cta gaa cga ctc ggc ttc aga ttt ccg gca ccc tga 816 Cys Ser Thr Thr Leu Glu Arg Leu Gly Phe Arg Phe Pro Ala Pro 260 265 270 <210> SEQ ID NO 46 <211> LENGTH: 271 <212> TYPE: PRT <213> ORGANISM: Drosophila melanogaster <400> SEQUENCE: 46 Met Glu Asp Glu Trp Gly Ser Phe Asp Arg Leu Pro Ser Val Pro Ser 1 5 10 15 Ala Ser Met Asp Leu Glu Thr Glu Asn Glu Val Val Ser Asn Trp Ser 20 25 30 Thr Leu Ala Asn Phe Thr Arg Leu Val Ala Gly Ala Ala Pro Glu Ile 35 40 45 Val Asn Tyr Thr Leu Asn Met Ile Asp Val Gly Val Gly Met Ala Thr 50 55 60 Asp Ile Ser Asn Leu Ser Val Pro Glu His Val Met Asp His Ala Pro 65 70 75 80 Gln Leu Ser Arg Ser Gly Leu Leu Lys Val Tyr Val Leu Ala Val Met 85 90 95 Ala Leu Phe Ser Leu Leu Gly Asn Leu Leu Thr Ile Trp Asn Ile Tyr 100 105 110 Lys Thr Arg Ile Ser Arg Arg Asn Ser Arg His Thr Trp Ser Ala Ile 115 120 125 Tyr Ser Leu Met Phe His Leu Ser Ile Ala Asp Val Leu Val Thr Trp 130 135 140 Phe Cys Ile Ile Gly Glu Ala Ala Trp Cys Tyr Thr Val Gln Trp Leu 145 150 155 160 Ala Asn Glu Leu Thr Cys Lys Leu Val Lys Leu Phe Gln Met Phe Ser 165 170 175 Leu Tyr Leu Ser Thr Tyr Val Leu Val Leu Ile Gly Val Asp Arg Trp 180 185 190 Ile Ala Val Lys Tyr Pro Met Lys Ser Leu Asn Met Ala Lys Arg Cys 195 200 205 His Arg Leu Leu Gly Gly Thr Tyr Ile Leu Ser Leu Val Leu Ser Leu 210 215 220 Pro Gln Ile Gly Thr Leu Gly Asp Ile Phe Leu Cys Pro Gly Ser Gln 225 230 235 240 Leu Ala Asp Lys Pro Glu Trp Asp Cys Ile Asn Gly Arg His Ser Leu 245 250 255 Cys Ser Thr Thr Leu Glu Arg Leu Gly Phe Arg Phe Pro Ala Pro 260 265 270 <210> SEQ ID NO 47 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 47 aaggtcatca aaatgctgat t 21 <210> SEQ ID NO 48 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 48 attgtagcag ctattgctca t 21 <210> SEQ ID NO 49 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 49 cagctcgttc gattcggtcc t 21 <210> SEQ ID NO 50 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 50 gtgacagcgg tcatagtccg a 21 <210> SEQ ID NO 51 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 51 atcgaggcat ccacctatgg c 21 <210> SEQ ID NO 52 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 52 aggtgggcgc aggcatcgta g 21 <210> SEQ ID NO 53 <211> LENGTH: 23 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 53 ttgctacgta gttctgagga atc 23 <210> SEQ ID NO 54 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 54 atgcaggtgg agagcttcat g 21 <210> SEQ ID NO 55 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 55 tggcagacga gtgcttcctg a 21 <210> SEQ ID NO 56 <211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 56 ggaccgctga agttgaccag 20 <210> SEQ ID NO 57 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 57 tggtctggta cctgctggtc a 21 <210> SEQ ID NO 58 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 58 gcgatgagcc atttgaccag c 21 <210> SEQ ID NO 59 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 59 gtgacccatg cgttcatcat c 21 <210> SEQ ID NO 60 <211> LENGTH: 19 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 60 ctgcagcatg ggcagaaag 19 <210> SEQ ID NO 61 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 61 gcgatcacct ggaagatctg c 21 <210> SEQ ID NO 62 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 62 tggtgatgcc aataggatac c 21 <210> SEQ ID NO 63 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 63 ctgttgcact tcctggtcta c 21 <210> SEQ ID NO 64 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 64 acgcacagct ccctgaattt c 21 <210> SEQ ID NO 65 <211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 65 gaggagcacg atgtgagtgg 20 <210> SEQ ID NO 66 <211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 66 cgtgtaaacg gataattctg 20 <210> SEQ ID NO 67 <211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 67 gtctggctga tacccagcta 20 <210> SEQ ID NO 68 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 68 acgctcttga ctttctcgaa c 21 <210> SEQ ID NO 69 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 69 ttcgcacacc agttctacga c 21 <210> SEQ ID NO 70 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 70 gcgttcatga agcagtaggt g 21 <210> SEQ ID NO 71 <211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 71 tacatctgca tcggacgtgg 20 <210> SEQ ID NO 72 <211> LENGTH: 19 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 72 cactatgccg cattgctcc 19 <210> SEQ ID NO 73 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 73 gtgatctatg tggtgatgag g 21 <210> SEQ ID NO 74 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 74 cctcgactgc acggtgctgg c 21 <210> SEQ ID NO 75 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 75 gtcatcgttc tgggcaattc a 21 <210> SEQ ID NO 76 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 76 gatgctcatg gccaccagca c 21 <210> SEQ ID NO 77 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 77 aacgtactgc gagtgatcgt g 21 <210> SEQ ID NO 78 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 78 aatggcaaag gtgacatcgt g 21 <210> SEQ ID NO 79 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 79 atgtgccgca tcagcgagtt c 21 <210> SEQ ID NO 80 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 80 gttaccggtg gctgtgaaca c 21 <210> SEQ ID NO 81 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 81 cagaaaccgc tcaaggagac g 21 <210> SEQ ID NO 82 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 82 cctcagacga gccgcagtta g 21 <210> SEQ ID NO 83 <211> LENGTH: 19 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 83 gcactggcac tgctgctgg 19 <210> SEQ ID NO 84 <211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 84 cacagccacc acggtgatgc 20 <210> SEQ ID NO 85 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 85 ggcactttgc cgtggatagt g 21 <210> SEQ ID NO 86 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 86 gaaccgatcg atggacatca g 21 <210> SEQ ID NO 87 <211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 87 catcagctcc tacctgctgc 20 <210> SEQ ID NO 88 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 88 cgtagagcag cggattgata c 21 <210> SEQ ID NO 89 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 89 catctcactg gcctgcagtg a 21 <210> SEQ ID NO 90 <211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 90 catgctcaga gtcgacttcg 20 <210> SEQ ID NO 91 <211> LENGTH: 20 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 91 gcggtaatgg cactgttctc 20 <210> SEQ ID NO 92 <211> LENGTH: 21 <212> TYPE: DNA <213> ORGANISM: Artificial Sequence <220> FEATURE: <223> OTHER INFORMATION: Description of Artificial Sequence: Primer <400> SEQUENCE: 92 ggatactgtg gagaaccggt a 21 

1. Polypeptide having the biological activity of a peptide receptor and comprising an amino acid sequence which has at least 70% identity with a sequence of SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44 or
 46. 2. Polypeptide according to claim 1, characterized in that the amino acid sequence corresponds to a sequence of SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44 or
 46. 3. Nucleic acid comprising a nucleotide sequence which encodes a polypeptide according to claim 1 or
 2. 4. Nucleic acid according to claim 3, characterized in that it is single- or double-stranded DNA or RNA.
 5. Nucleic acid according to claim 4, characterized in that it is a fragment of genomic DNA or cDNA.
 6. Nucleic acid according to claim 3, characterized in that the nucleotide sequence corresponds to a sequence of SEQ ID NO:1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43 or
 45. 7. Nucleic acid according to claim 3, characterized in that it hybridizes under stringent conditions to the sequences of SEQ ID NO:1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43 or
 45. 8. DNA construct comprising a nucleic acid according to any of claims 3 to 7 and a heterologous promoter.
 9. Vector comprising a nucleic acid according to any of claims 3 to 7 or a DNA construct according to claim
 8. 10. Vector according to claim 9, characterized in that the nucleic acid is operatively linked to regulatory sequences which ensure the expression of the nucleic acid in pro- or eukaryotic cells.
 11. Host cell containing a nucleic acid according to any of claims 3 to 7, a DNA construct according to claim 8 or a vector according to claim 9 or
 10. 12. Host cell according to claim 11, characterized in that it is a prokaryotic cell, in particular E. coli.
 13. Host cell according to claim 11, characterized in that it is a eukaryotic cell, in particular a mammalian or insect cell.
 14. Antibody which binds specifically to a polypeptide according to claim 1 or
 2. 15. Transgenic invertebrate containing a nucleic acid according to any of claims 3 to
 7. 16. Transgenic invertebrate according to claim 15, characterized in that it is Drosophila melanogaster or Caenorhabditis elegans.
 17. Transgenic progeny of an invertebrate according to claim 15 or
 16. 18. Method of producing a polypeptide according to claim 1 or 2, comprising (a) culturing a host cell according to any of claims 11 to 13 under conditions which ensure the expression of the nucleic acid according to any of claims 3 to 7, or (b) expressing a nucleic acid according to any of claims 3 to 7 in an in vitro system, and (c) obtaining the polypeptide from the cell, the culture medium or the in vitro system.
 19. Method of producing a nucleic acid according to any of claims 3 to 7, comprising the following steps: (a) full chemical synthesis in a manner known per se, or (b) chemical synthesis of oligonucleotides, labelling of the oligonucleotides, hybridizing the oligonucleotides to DNA of a genomic library or cDNA library generated from insect genomic DNA or insect MRNA, respectively, selecting positive clones and isolating the hybridizing DNA from positive clones, or (c) chemical synthesis of oligonucleotides and amplificiation of the target DNA by means of PCR.
 20. Method of producing a transgenic invertebrate according to claim 15 or 16, which comprises introducing a nucleic acid according to any of claims 3 to 7 or a vector according to claim 9 or
 10. 21. Method of finding novel active compounds for crop protection, in particular compounds which alter the properties of polypeptides according to claim 1 or 2, comprising the following steps: (a) providing a host cell according to any of claims 11 to 13, (b) culturing the host cell in the presence of a chemical compound or a mixture of chemical compounds, and (c) detecting altered properties.
 22. Method of finding a chemical compound which binds to a polypeptide according to claim 1 or 2, comprising the following steps: (a) bringing a polypeptide according to claim 1 or 2 or a host cell according to any of claims 11 to 13 into contact with a chemical compound or a mixture of chemical compounds under conditions which permit the interaction of a chemical compound with the polypeptide, and (b) determining the chemical compound which binds specifically to the polypeptide.
 23. Method of finding a chemical compound which alters the expression of a polypeptide according to claim 1 or 2, comprising the following steps: (a) bringing a host cell according to any of claims 11 to 13 or a transgenic invertebrate according to claim 15 or 16 into contact with a chemical compound or a mixture of chemical compounds, (b) determining the concentration of the polypeptide according to claim 1 or 2, and (c) determining the chemical compound which specifically affects the expression of the polypeptide.
 24. Use of a polypeptide according to claim 1 or 2, of a nucleic acid according to any of claims 3 to 7, of a vector according to claim 9 or 10, of a host cell according to any of claims 11 to 13, of an antibody according to claim 14 or of a transgenic invertebrate according to claim 15 or 16 for finding novel active compounds for crop protection or finding genes which encode polypeptides which participate in the synthesis of functionally similar peptide receptors in insects.
 25. Use of a modulator of a polypeptide according to claim 1 or 2 as insecticide. 